*  Anti-RASGRF1 antibody [EPR1790(2)] Recombinant (ab111830) | Abcam
Rabbit recombinant monoclonal RASGRF1 antibody [EPR1790(2)] validated for WB and tested in Human and Rat. Referenced in 1 ... Ras specific nucleotide exchange factor CDC25 antibody. *Ras-GRF1 antibody. *Ras-specific guanine nucleotide-releasing factor 1 ... Ras protein specific guanine nucleotide releasing factor 1 antibody. *Ras specific guanine nucleotide releasing factor antibody ... Contains 1 N-terminal Ras-GEF domain.. Contains 2 PH domains.. Contains 1 Ras-GEF domain. ...
  https://www.abcam.com/rasgrf1-antibody-epr17902-ab111830.html
*  Ras-GRF1 - Wikipedia
In this way, Ras-GRF1 has a key role in regulating the RAS signaling pathway. Ras-GRF1 knockout mice have been shown to have ... Ras-GRF1 has also been shown to be upstream from IGF1, allowing it to control growth in mice. Although it is sometimes known as ... Ras-GRF1 is a paternally expressed imprinted gene, meaning that only the paternal allele of the gene is translated into protein ... Ras-GRF1 is a guanine nucleotide exchange factor. Its function is to release guanosine diphosphate, GDP, from the signaling ...
  https://en.wikipedia.org/wiki/Ras-GRF1
*  Tissue expression of RASGRF1 - Staining in oral mucosa - The Human Protein Atlas
GRF1, GRF55, H-GRF55, PP13187) in oral mucosa tissue. Antibody staining with HPA041965 and CAB010413 in immunohistochemistry. ... RAS pathway related proteins. Ribosomal proteins. RNA polymerase related proteins. Transcription factors. Transporters. Voltage ...
  http://www.proteinatlas.org/ENSG00000058335-RASGRF1/tissue/oral+mucosa
*  The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis...
Production of MMP-1 and MMP-3 in RA but not non-RA synovial tissue positively correlated with expression of RasGRF1 and co- ... localized in cells expressing RasGRF1. RasGRF1 overexpression in FLS induced production of MMP-3, and RasGRF1 silencing ... Expression of RasGRF1 was significantly enhanced in RA synovial tissue, and detected in FLS and synovial macrophages in situ. ... Enhanced expression and post-translational modification of RasGRF1 contributes to MMP-3 production in RA synovial tissue and ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar2785
*  Trk | China-Mainland | Sigma-Aldrich
Ras-GRF1. Kalirin. Dynein light chain. ARMS. c-Abl. SAP Shc. PLC-γ1. FRS2. SH2-B. APS. Fyn. SAP. Dynein light chain. Shc. PLC- ... These proteins link Trk to the Ras/Raf/MEK/MAP kinase, Rap1/Braf, PI3-kinase/Akt/GSK3-β/ILK, ΔNp73 (p53 family member) and PKC ... and APS/SH2-B adapter proteins and regulators of Ras function, the calcium and PKC regulator phospholipase C-γ1, and the ...
  https://www.sigmaaldrich.com/china-mainland/zh/technical-documents/articles/biology/rbi-handbook/protein-serine-threonine-tyrosine-kinases/trk.html
*  RAS Pathway v2.0 - National Cancer Institute
... scientific lead of the RAS Initiative, incorporates over 30 suggestions from the RAS community to formulate an updated version ... CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1. RASGRF2. Ras protein-specific guanine nucleotide-releasing factor ... RAS protein activator like-3 [none]. RASGRF1. Ras protein-specific guanine nucleotide-releasing factor 1. ... Ras homolog family member A. ARH12, ARHA, RHO12, RHOH12. RHOB. Ras homolog family member B. ARH6, ARHB, MST081, MSTP081, RHOH6 ...
  https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2015/ras-pathway-v2
*  Rasgrf2 - Ras-specific guanine nucleotide-releasing factor 2 - Mus musculus (Mouse) - Rasgrf2 gene & protein
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for ... "Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation ... The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation.By similarity ... IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR023578. Ras_GEF_dom_sf. IPR001895. RASGEF_cat_dom ...
  http://www.uniprot.org/uniprot/P70392
*  Gene Expression sub-cluster 37
Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix ... ...
  http://www.biomedsearch.com/cluster/10/Gene-Expression/sub-37-p12.html
*  September 2007 - Fight Aging!
Genes involved in Ras and ubiquitin pathways, Ras-GRF1, RAC3 and UBE2D3, were downregulated. The changes suggest resveratrol ... Given that INK4a is induced by Ras overexpression as a tumor-suppressor mechanism the decrease in INK4a expression would be due ... directly to a reduction in Ras pathway activity.. Chronic resveratrol treatment did not increase the time required to reach ... rather stimulates interaction of SIRT1 with FOXO3a by inducing FOXO3a nuclear localization through the downregulation of Ras ...
  https://www.fightaging.org/archives/2007/09/
*  Guanine nucleotide exchange factor - Wikipedia
Ras-GRF1 Kalirin Ephexin5 is a RhoA GEF involved in neuronal synapse development. G proteins Guanine Nucleotide exchange factor ... The CDC25 homology domain, also called the RasGEF domain, is the catalytic domain of many Ras GEFs, which activate Ras GTPases ... SOS can act as a GEF to activate Rac1, a RhoGTPase, in addition to its role as a GEF for Ras. SOS is therefore a link between ... For example, SOS1, the Ras GEF in the MAPK/ERK pathway, is recruited by the adaptor protein GRB2 in response to EGF receptor ...
  https://en.wikipedia.org/wiki/Guanine_nucleotide_exchange_factor
*  MAPK8IP2 - Wikipedia
Buchsbaum RJ, Connolly BA, Feig LA (2002). "Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 ...
  https://en.wikipedia.org/wiki/MAPK8IP2
*  T-cell lymphoma invasion and metastasis-inducing protein 1 - Wikipedia
Buchsbaum RJ, Connolly BA, Feig LA (Jun 2002). "Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the ... Michiels F, Habets GG, Stam JC, van der Kammen RA, Collard JG (May 1995). "A role for Rac in Tiam1-induced membrane ruffling ... It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain. TIAM1 modulates the ... Habets GG, van der Kammen RA, Stam JC, Michiels F, Collard JG (Apr 1995). "Sequence of the human invasion-inducing TIAM1 gene, ...
  https://en.wikipedia.org/wiki/T-cell_lymphoma_invasion_and_metastasis-inducing_protein_1
*  TNK2 - Wikipedia
2000). "Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the ...
  https://en.wikipedia.org/wiki/TNK2
*  USP8 - Wikipedia
Ras-GRF1". J. Biol. Chem. 276 (42): 39448-54. doi:10.1074/jbc.M103454200. PMID 11500497. Strausberg RL, Feingold EA, Grouse LH ... 2001). "Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide ...
  https://en.wikipedia.org/wiki/USP8
*  C-Raf - Wikipedia
"Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42- ... Han L, Colicelli J (March 1995). "A human protein selected for interference with Ras function interacts directly with Ras and ... and even aid in the recognition of activated Ras (GTP-Ras). The close proximity of these two domains as well as several lines ... "Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface". Biochemistry. 34 ( ...
  https://en.wikipedia.org/wiki/C-Raf
*  List of MeSH codes (D12.776) - Wikipedia
... ras-GRF1 MeSH D12.776.402.300.700.700 - son of sevenless proteins MeSH D12.776.402.300.700.700.330 - sos1 protein MeSH D12.776. ... ras) MeSH D12.776.624.664.520.750.750 - oncogene protein p55(v-myc) MeSH D12.776.624.664.520.750.760 - oncogene protein pp60(v- ... ras) MeSH D12.776.964.700.750.750 - oncogene protein p55(v-myc) MeSH D12.776.964.700.750.760 - oncogene protein pp60(v-src) ... ras) MeSH D12.776.964.775.750.750 - oncogene protein p55(v-myc) MeSH D12.776.964.775.750.760 - oncogene protein pp60(v-src) ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
*  List of MeSH codes (D12.776.476) - Wikipedia
... ras guanine nucleotide exchange factors MeSH D12.776.476.325.300.700.500 -- ras-grf1 MeSH D12.776.476.325.300.700.700 -- son of ... ras) MeSH D12.776.476.525.500.600 -- proto-oncogene proteins p21(ras) MeSH D12.776.476.525.700.050 -- cdc42 gtp-binding protein ... ras gtpase-activating proteins MeSH D12.776.476.325.150.500.460 -- neurofibromin 1 MeSH D12.776.476.325.150.500.500 -- p120 ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.476)
*  List of MeSH codes (D12.644) - Wikipedia
... ras guanine nucleotide exchange factors MeSH D12.644.360.325.300.700.500 --- ras-grf1 MeSH D12.644.360.325.300.700.700 --- son ... ras) MeSH D12.644.360.525.500.600 --- proto-oncogene proteins p21(ras) MeSH D12.644.360.525.700 --- rho gtp-binding proteins ... ras gtpase-activating proteins MeSH D12.644.360.325.150.500.460 --- neurofibromin 1 MeSH D12.644.360.325.150.500.500 --- p120 ... ras proteins MeSH D12.644.360.525.500.300 --- oncogene protein p21( ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
*  KRAS - Wikipedia
"Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42- ... "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras ... KRAS ( K-ras or Ki-ras) is proto-oncogene corresponding to the oncogene first identified in Kirsten rat sarcoma virus and the ... KRAS binds GTP present in the cytosol and the GEF is released from ras-GTP. Other members of the Ras family include: HRAS and ...
  https://en.wikipedia.org/wiki/KRAS
*  Anti-apoptotic Ras signalling cascade - Wikipedia
2Hypoinsulinemia Alleviates the Grf1/Ras/Akt Anti-Apoptotic Pathway and Induces Alterations of Mitochondrial Ras Trafficking in ... The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade that involves the Ras protein and ... The anti-apoptotic STAT pathway does not involve Ras. Ras subfamily "Gefitinib-sensitizing EGFR mutations in lung cancer ... "Pathways potentiated by oncogenic Ras to modulate apoptosis induced by anticancer agent FR901228 " 2005 [1] Diagram of ras ...
  https://en.wikipedia.org/wiki/Anti-apoptotic_Ras_signalling_cascade
*  MLLT4 - Wikipedia
... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell-cell adhesions downstream of Ras activation. It is fused with ... Erdmann RA, Margelisch U, Moelling K (Jul 2003). "The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and ... "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras ...
  https://en.wikipedia.org/wiki/MLLT4
*  MRAS - Wikipedia
... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the ... M-Ras is a member of the small GTPase superfamily under the Ras family, which also includes Rap1, Rap2, R-Ras, and R-Ras2 (TC21 ...
  https://en.wikipedia.org/wiki/MRAS