... peptide 19-2.5 belongs to the class of synthetic anti-lipopolysaccharide peptides; however, its activity is not restricted to ... We hypothesized that peptide 19-2.5 interacts with heparanase and/or HS, thereby reducing the levels of circulating HS- ... Our data indicate that the treatment of septic mice with peptide 19-2.5 compared to untreated control animals lowers levels of ... The ex vivo addition of peptide 19-2.5 to plasma of septic shock patients decreases heparanase activity but not heparanase ...

... is known to be a potent reproductive peptide hormone involved in ovulation and egg-laying in some aquatic molluscs. Two other ...

Latency-associated peptide (LAP) - expressing regulatory T cells (Tregs) are important for immunological self-tolerance and ...

COCs were cultured with C-type natriuretic peptide (CNP; 0, 50, 100, 200 nM) for 6 and 8 h. Nuclear stage was assessed, ... Natriuretic peptide Is the Subject Area "Natriuretic peptide" applicable to this article? Yes. No. ...

... leptin and adiponectin are the most abundantly secreted peptides [11]. Their role in the regulation of whole body energy ...

MS/MS based peptide and protein identifications were validated using Scaffold software. Peptide identifications were accepted ... Peptide separation took place on a PicoFrit column BioBasic C18, 10 cm x 0.075 mm internal diameter, with a linear gradient ... The sequence coverage of the sample with 36 identified peptides is shown in Fig 9B. However, our results do not exclude the ... Peptide samples were separated by online reversed-phase (RP) nanoscale capillary liquid chromatography (nanoLC) and analyzed by ...

2008) Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major ... In order to clone the entire env DNA sequences (including signal peptide and entire gp41 endodomain) we have generated unique ... 1986) Induction of anti-HIV neutralizing antibodies by synthetic peptides. EMBO J 5: 3065-3071. PubMed: 3466790. * View Article ... 2009) Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 ...

... antibodies were raised in rabbits against the peptides MMASYPEPEDAAGAALL and WDHDSKTGALHSRLDL, previously utilised in [114]. ...

2010) Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells ... Accordingly, our laboratories have developed small molecule, non-peptide ligands of p75NTR that promote survival-related ... 2008) Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. PLoS One 3: ...

... toxin and venom peptides. We trained two general predictors of peptide bioactivity, one focused on short peptides (4-20 amino ... We noted some striking differences in the features of short peptide and long peptide predictions, in particular, high scoring ... An implementation of the predictive method, PeptideRanker, may be used to identify among a set of peptides those that may be ... We hypothesized that bioactive peptides may share more general features, and assessed this by contrasting the predictive power ...

2001) beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking ... 2001) Reduced levels of amyloid beta-peptide antibody in Alzheimer disease. Neurology 57: 801-805. pmid:11552007 * View Article ... 2009) Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing ... were coated with 50 μl of 5 μg/ml recombinant tau-441 peptide in 0.1 M sodium phosphate buffer (2.62 g/l sodium dihydrogen ...

9) Of note, CSF levels of Aβ peptide go down with increasing disease burden, and therefore are a surrogate for Aβ accumulation ... CSF beta-amyloid peptide (Aβ42), total tau, phosphorylated tau levels at baseline and follow up every 2 years up to 10 years ... Zheng WH, Bastianetto S, Mennicken F, Ma W, Kar S. Amyloid beta peptide induces tau phosphorylation and loss of cholinergic ...

Drosophila Polycomb (Pc or M33 in mouse), a core subunit of PRC1, selectively binds to histone H3 tail peptide trimethylated at ...

Manuscript Review and Publication ...

Examples are: how ATP hydrolysis and an enzyme contrive to perform work, such as active transport; how peptides are formed from ... amino acids and DNA from nucleotides; how proteases cleave peptide bonds, how bone mineralises; how enzymes distinguish between ...

This observation led us to establish a fundamental protein design principle that only right-handed peptide folds can properly ...

... mediated degradation of several biologically-active peptides (angiotensin I, bradykinin, hemo-regulatory peptide Ac-SDKP). ...

... peptides and small molecular compounds with high specificity for ion channels and are therefore considered to be promising ...

Furthermore, exposure to FlyNap eliminated the cardioacceleratory effect of crustacean cardioactive peptide (CCAP), and reduced ...

The peptide also promotes the fusion (or hemifusion) of membranes containing phosphatidylglycerol (POPG). The aggregation and ... rBPI21 is a 21 kDa peptide based on the N-terminal region of the neutrophil bactericidal/permeability-increasing protein (BPI ... Antimicrobial peptides (AMPs) are important potential alternatives to conventional therapies against bacterial infections. ... fusion of negatively charged LUV are peptide concentration-dependent until massive aggregation is reached, followed by sample ...

... and non-ribosomal peptide synthetase (NRPS) genes, respectively. The sequence tags correspond to PKS-derived ketosynthase ...

... the typhoid toxin and the peptide-polyketide colibactin, all produced by Gram-negative bacteria. The presence of genetic mobile ...