There is increasing evidence that obesity may be an independent risk factor for complications in both type 2 and type 1 ... The increasing incidence of obesity accounts in large part for the emergence of type 2 diabetes. Drug treatment of ... Obesity is an important risk factor for the development of type 2 diabetes. ... Obesity is an important risk factor for the development of type 2 diabetes. The increasing incidence of obesity accounts in ...
... widely accepted that inflammation and oxidative stress are key processes that underlie metabolic complications during obesity, ... widely accepted that inflammation and oxidative stress are key processes that underlie metabolic complications during obesity, ...
Golubic R. et al, (2023), Diabetes, Obesity and Metabolism * Assessment of Cardiac Energy Metabolism, Function, and Physiology ...
Diabetes, Obesity and Metabolism. Publication Date. 01/04/2015. Volume. 17. Pages. 395 - 402 ...
Neuroimmunity in Obesity and Cardiac function.. PIs: Associate Professor Ana Domingos, Professor Irina Udalova, Professor ...
Taking into account the prevalence of obesity in the general population, males had a 2.5-fold relative risk of presenting with ... diabetes, although with increasing obesity the male preponderance was lost. Presentation increased with age up to the age of 55 ... Taking into account the prevalence of obesity in the general population, males had a 2.5-fold relative risk of presenting with ... Characteristics of newly presenting type 2 diabetic patients: male preponderance and obesity at different ages. Multi-center ...
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Quantification of Femoral Adipose Tissue Provides Novel Mechanistic Insights Into the "Obesity Paradox": a Translational ... Quantification of Femoral Adipose Tissue Provides Novel Mechanistic Insights Into the "Obesity Paradox": a Translational ...
We use cookies to ensure that we give you the best experience on our website. If you click Accept all cookies well assume that you are happy to receive all cookies and you wont see this message again. If you click Reject all non-essential cookies only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click Find out more for information on how to change your cookie settings. ...
PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation. Journal article Pezhman L. et al, (2023), Clin ... food intake and inflammation and as such have become major drug targets for the treatment of diabetes and obesity. We are ...
Rider Group: Obesity, Heart Failure, Linking Myocardial Metabolism and Function Per Arvidsson Postdoctoral Research Assistant ...
... suggest that iron accumulation and metabolism may play a role in the development of metabolic diseases including obesity, type ... suggest that iron accumulation and metabolism may play a role in the development of metabolic diseases including obesity, type ...
Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity. Journal article ...
Beneficial Cardiovascular Effects of Bariatric Surgery Versus Dietary Weight Lass in Obesity ... Beneficial Cardiovascular Effects of Bariatric Surgery Versus Dietary Weight Lass in Obesity ...
Findings from this analysis expand our knowledge of the genetic basis of obesity. ... Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast ... Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast ... Findings from this analysis expand our knowledge of the genetic basis of obesity. ...
Metabolic Syndrome: Insulin Resistance, Obesity, Diabetes Mellitus, Hypertension, Physical Activity and Genetic Factors ... Metabolic Syndrome: Insulin Resistance, Obesity, Diabetes Mellitus, Hypertension, Physical Activity and Genetic Factors ...
... is an understudied trait in obesity biology. NAT can be quantified using dual X-ray absorptiometry (DXA), a tool commonly used ... Expansion of neck adipose tissue (NAT) is an understudied trait in obesity biology. NAT can be quantified using dual X-ray ...
He has interests in obesity, lipodystrophy and basic and translational work with cannabinoids. We are delighted that he will be ...
This suggests that the rate of ATP delivery is maintained, but this has never been explored in human obesity. We hypothesized ... RESULTS: At rest, although myocardial phosphocreatine/ATP was 14% lower in obesity (1.9±0.3 versus 2.2±0.2, P,0.001), kfCkrest ... This highlights myocardial energy delivery through CK as a potential therapeutic target to improve symptoms in obesity-related ... Whereas myocardial energetics and diastolic function are impaired in obesity, systolic function is usually preserved. ...
The high absolute risk associated with obesity at any level of genetic risk highlights the importance of universal rather than ... Examination of absolute risks by strata showed the importance of obesity for T2D risk. The 10-y cumulative incidence of T2D ... The high absolute risk associated with obesity at any level of genetic risk highlights the importance of universal rather than ... Examination of absolute risks by strata showed the importance of obesity for T2D risk. The 10-y cumulative incidence of T2D ...
... was to describe cortisol metabolism and metabolic characteristics of a large PCOS cohort and to delineate the effect of obesity ... Altered peripheral cortisol metabolism has been reported in PCOS, but also in simple obesity. OBJECTIVE: The aim of the study ... androgen and cortisol metabolite excretion and increased 5 alpha-reductase activity that cannot be explained by obesity alone. ... Altered peripheral cortisol metabolism has been reported in PCOS, but also in simple obesity. OBJECTIVE: The aim of the study ...
DESIGN: In genetic studies of 2,462 people with severe obesity, we identified 23 rare heterozygous variants in SRC-1. We ... CONCLUSIONS: SRC-1 variant carriers exhibit hyperphagia in childhood, severe obesity and clinical features of partial hormone ... have been identified in people with severe obesity and impair melanocortin signaling in cells and mice. As a result, obese ... tissue fibrosis and hepatic fibrosis in young patients suggests that close monitoring for the early development of obesity- ...
RESULTS: The minor A-allele of the FTO variant rs9939609 was associated with increased risk of obesity (OR 1.15, 95% CI 1.08- ... METHODS: Random-effect meta-analysis was performed on pooled data from eight studies (n = 28,394) for obesity and related ... Our study provides evidence of association between common FTO variant and obesity risk among Indians with comparable effect ... To investigate the magnitude of association of FTO variants with obesity, type 2 diabetes (T2DM), and related traits among ...
Cardiac and hepatic phenotype of diabetes in the presence and the absence of obesity - mechanistic role of ectopic/visceral ... Cardiac and hepatic phenotype of diabetes in the presence and the absence of obesity - mechanistic role of ectopic/visceral ...
Patients with central obesity but with no evidence of hypopituitarism have relative GH deficiency and it is exciting to ... notably visceral obesity, insulin resistance, osteoporosis and increased vascular mortality. Our hypothesis was that many of ... the GH/IGF-I modulation of cortisol metabolism may underpin the pathogenesis of common diseases such as central obesity and ... HSD1 in omental adipose tissue can stimulate glucocorticoid-induced adipocyte differentiation which may lead to central obesity ...
Childhood type 2 diabetes appears to be similar to the metabolic syndrome in adults and is characterized by obesity, ... Childhood type 2 diabetes appears to be similar to the metabolic syndrome in adults and is characterized by obesity, ...
Crh -120/+ mice, when compared with wild-type littermates, had obesity, muscle wasting, thin skin, hair loss, and elevated ... Crh -120/+ mice, when compared with wild-type littermates, had obesity, muscle wasting, thin skin, hair loss, and elevated ...
... along with the associated metabolic consequences of obesity. We perform whole body human physiological studies to understand ...
Therapeutic inhibition of 11beta-HSD1 reductase activity in patients with obesity and the metabolic syndrome, as well as in ... Therapeutic inhibition of 11beta-HSD1 reductase activity in patients with obesity and the metabolic syndrome, as well as in ... Obesity, Organ Specificity, Osteoporosis, Recombinant Proteins, Sequence Alignment, Substrate Specificity, Transcription, ...