Canine neutrophils can be induced to adhere in vitro to isolated adult cardiac myocytes by stimulation of the neutrophils with ... Neutrophil-myocyte adhesion may be of pathogenic significance because it may enhance the cytotoxic activity of the neutrophil. ... Neutrophil adherence to isolated adult cardiac myocytes. Induction by cardiac lymph collected during ischemia and reperfusion. ... Neutrophil adherence to isolated adult cardiac myocytes. Induction by cardiac lymph collected during ischemia and reperfusion. ...

... on neutrophil random and chemotactic movement. Preexposure of neutrophils for 15-30 min to 1-10 micrograms/ml PUFA reduced the ... Neutrophil migration inhibitory properties of polyunsaturated fatty acids. The role of fatty acid structure, metabolism, and ...

... neutrophils; Mono, monocytes; DC, dendritic cells; Mϕ, macrophages. (. C. ) Enumeration and representative flow plot of ...

Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods. 2006;3(4):287-293.. View ... With IL-6, granulopoiesis persisted with GATA2-deficient fetal progenitors (Figure 11), and neutrophils exist in pediatric and ... disproportionately generate neutrophils (110). In GATA2-deficient fetal progenitors, Il6ra and Il6st upregulation endowed ... elevates neutrophils, monocytes, eosinophils, dendritic cells, and myeloid-derived suppressor cells (117). CSF2RB mediates FLT3 ...

Neutrophil-derived glutamate regulates vascular endothelial barrier function. J. Biol. Chem. 2002. 2002:14801-14811. ... CD 47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J. Cell Biol. 1996 ... consequences for CD11b/18-mediated interactions with neutrophils. Mol. Med. 1996. 2:489-505. View this article via: PubMed ...

Neutrophils are a characteristic feature of the alveolitis of idiopathic pulmonary fibrosis (IPF). a chronic disorder limited ... One mechanism by which neutrophils may be selectively attracted to lung and not other tissues is via the secretion of the ... These studies suggest that neutrophils are attracted to the lung in patients with IPF by a potent chemotactic factor released ... Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis.. ...

Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. Proc Natl Acad Sci ... Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry 1995. 34:14609- ... Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. J ... Coactivation of neutrophils and certain epithelial cells treated with ASA generates a novel class of 15R-containing LXs termed ...

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the ... This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH ... RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS ... one with high intrahepatic neutrophils (Neuhi), but low levels of CD8+ T cells, and vice versa. ...

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012; ... Western blots of thrombus lysates showed thrombi from WT and Fibγ390-396A mice did not differ in neutrophil, platelet, or ... C) Total neutrophil content of thrombus lysates, measured by Ly6G antigen. (D) Total platelet content of thrombus lysates, ... LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J Clin Invest. 1997;99(6):1340-1350.. View this ...

Both cold and warm IRI activate the innate immune system, including liver Kupffer cells and neutrophils. The adaptive immune ...

2.75 ± 0.56 mg/d hAgt RNAi) (Figure 3B). Additionally, renal neutrophil gelatinase-associated lipocalin (Ngal) mRNA expression ...

Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma. Immunology. 2011;132(1 ... OPN is upregulated within glioblastoma-infiltrating neutrophils and macrophages, and is associated with infiltration of these ...

However, the effects of this free radical species on neutrophil (PMN)-endothelial cell interactions is largely unknown. We ...

In PMA-stimulated neutrophils and in a cell-free translocation assay with neutrophil membranes and cytosol, the association of ... Both eosinophils and neutrophils, however, contained immunoreactive 92-kD gelatinase indicating that active expression occurred ... associated with normal amounts of nonfunctional cytochrome b558 in the patients neutrophils. ...

These results present an intriguing role for cycling neutrophils as a sensor of inflammation induced by injury, potentially ... Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. ... Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. ... In sepsis, plasma cfDNA is mostly derived from neutrophil extracellular trap (NET) degradation. Proposed NET-directed ...

CD11b+Ly6C-Ly6G+ neutrophils and (. H. and I. ) CD11b+Ly6ChiLy6G-F4/80+ inflammatory monocytes; reported as percentage of CD11b ... Representative gating strategy for neutrophils and monocytes. Representative dot plots and quantitation for (. F. and G. ) ...

High-dose alveolar E. coli endotoxin caused a 10-fold increase in the number of leukocytes, particularly neutrophils, that ...

Under these conditions, infiltration of neutrophils and monocytes to the dermis of the ear was blocked, in keeping with delayed ... dermal infiltrations of neutrophils and monocytes were detected in the nontreated ears before disease onset but were suppressed ...

Treatment response was assessed using standard criteria (80). CR was defined as ,5% blasts in BM with neutrophil and platelet ...

... series of events that integrate epithelial responses with those of resident and infiltrating immune cells including neutrophils ...

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus ... Several studies have described the potential role of neutrophils and NETosis in local lung pathology as well as shifts in ... evidence of emergency myelopoiesis and neutrophil dysregulation in severe disease (6), and an upregulation of the TNF/IL-1β- ... These outcomes were associated with suppression of neutrophil recruitment and production of cytokines and chemokines by ...

We recently reported a key role for neutrophils - neutrophil extracellular traps (NETs), in particular - in the thrombotic ... In patients, APS neutrophils demonstrated a proinflammatory signature with overexpression of genes relevant to IFN signaling, ... The thrombosis phenotype was restored in PSGL-1-deficient mice by infusion of WT neutrophils, while an anti-PSGL-1 monoclonal ... a key adhesion molecule overexpressed in APS neutrophils. The introduction of APS IgG (as compared with control IgG) markedly ...

... and neutrophils (Table 1), although most of these cells rarely migrate to the LNs (25, 28, 31-34). Among the most well-studied ...

... and neutrophils) IKKβ- or JNK1-KO mice were generated using the Cre-LoxP system (24) or bone marrow transplantation techniques ... including neutrophils and lymphocytes. Since Th1 lymphocytes can induce proinflammatory responses (110, 111) and can attract ...

... was shown by their induction of endothelial tissue factor and enhancement of endothelial adhesiveness for neutrophils, both of ...

... and recruitment of eosinophils and neutrophils to the airway. It remains unclear whether this chemotactic effect of adenosine ...

mice treated with BA or after bile duct ligation, where less hepatic infiltration of neutrophils was detected. Neutrophils in ... These hepatocyte-specific cytokines stimulated neutrophil chemotaxis. Inflammatory injury was mitigated in Ccl2. -/- ...

In addition, the neutrophil chemoattractant CXCL1 (31) and the T cell chemoattractant CCL5 (RANTES) (32) were decreased in ... A novel role for neutrophils as critical activators of NK cells. J Immunol. 2008;181(10):7121-7130.. View this article via: ... IL-18, a mediator of type 1 immune response, is a major neutrophil product and activator of NK cells, directly inducing NK ... In addition to the NK cell population, immunostaining for the granulocyte marker Ly6G in decidua showed that neutrophils were ...

... suppression of neutrophil extracellular trap (NET) formation, and inhibition of neutrophil migration. Mechanistically, reduced ... linking PTP1B inhibition to promoting an aged-neutrophil phenotype. Considering that dysregulated activation of neutrophils has ... Treatment with PTP1B inhibitors attenuated the aberrant neutrophil function that drives ALI and was associated with release of ... PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils. ...

We performed a longitudinal analysis to assess changes in DNA methylation in lupus neutrophils over 4 years of follow-up and ...