Consequently, accurate anatomical reconstructions of neuron morphology and synaptic localization are critical when modeling and ... to automate synaptic contact detection on dendrites of individually labeled neurons from 3D immunofluorescence image sets. In ... and its effectiveness is evaluated through analysis of primary sensory afferent terminals on motor neurons. Optimization of ... The spatial distribution of synaptic inputs on the dendritic tree of a neuron can have significant influence on neuronal ...

For example, Renshaw cells (RC) are inhibitory interneurons that prevent motor neurons from over-activity. A distinguishing ... We analyze anatomical location; cellular density; expression of neurotransmitters; motor neuron and sensory afferent contacts; ... but knowledge regarding the function and connectivity of these neurons is limited. We hypothesize CB expression serves a ... expression of calcium binding proteins CB, calretinin and parvalbumin; and premotor neuron identification. ...

... proprioceptive sensory neurons in vitro. Together, our findings demonstrate that Cdc42 in presynaptic neurons is required for ... neurons. In mice lacking Cdc42 in presynaptic sensory neurons, proprioceptive sensory axons appropriately reach the ventral ... Temporally targeted deletion of Cdc42 in sensory neurons after sensory-motor circuit establishment reveals that Cdc42 does not ... spinal cord, but significantly fewer synapses are formed with motor neurons compared with wild-type mice. Concordantly, ...

... but only at end-stage disease in motor neurons innervating distal hindlimb muscles. Motor neuron loss follows afferent synapse ... Deafferentation of motor neurons is an early event in SMA and may be a primary cause of motor dysfunction that is amenable to ... SMA motor neurons show reduced proprioceptive reflexes that correlate with decreased number and function of synapses on motor ... These abnormalities occur at an early stage of disease in motor neurons innervating proximal hindlimb muscles and medial motor ...

... of the new experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons ... New information has emerged on the response of spinal neurons to injury of either the spinal cord or peripheral nerves ... New information has emerged on the response of spinal neurons to injury of either the spinal cord or peripheral nerves ... of the new experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons ...

Mouse neurons (N2a) cultured in hypoxia condition for 6 hr followed by 24 hr reoxygenation. The H/R-injured N2a cells were ... Here, we isolated the circulating EPC-EXs from exercise mice (10 m/min) and investigated their role in neurons subjected to H/R ... Altogether, exercise boosts the effects of EPC-EXs on protecting neurons against H/R insult through activating the miR-126/PI3k ... Whether exercise can regulate the function of circulating EPC-EXs on protecting neurons against hypoxia/reoxygenation (H/R) ...

... the spiking activity of the neuron and the combined spiking activity of all hairs are extracted by the cercal sensory system. ... the spiking activity of the neuron and the combined spiking activity of all hairs are extracted by the cercal sensory system. ...

... stimulation paradigms could provide potential rehabilitation interventions for suppressing the excitability of neurons to ... the effects of delivering focal electrical stimuli to the central nervous system to modulate the firing rate of neurons and ... the effects of delivering focal electrical stimuli to the central nervous system to modulate the firing rate of neurons and ... stimulation paradigms could provide potential rehabilitation interventions for suppressing the excitability of neurons to ...

For example, the receptor structure switches from a monomeric α or heteromeric α2β in immature neurons to an α1β receptor type ... the high level of glycinergic transmission in immature spinal neurons modulates neuronal excitability causing membrane ... in mature neurons. Together with these changes in receptor subunits, the postsynaptic cluster size increases with development. ... play a major role in the excitability of spinal cord and brain stem neurons. During development, several properties of these ...

Loss of ETV1/ER81 in Motor Neurons Leads to Reduced Monosynaptic Inputs From Proprioceptive Sensory Neurons, David R. Ladle and ... Increasing Motor Neuron Excitability to Treat Weakness in Sepsis, Paul Nardelli, Randall Powers, Tim C. Cope, and Mark M. Rich ... Distinct Roles for Motor Neuron Autophagy Early and Late in the sod1g93a Mouse Model of Als, Noam D. Rudnick, Christopher J. ... Calcium Imaging of Parvalbumin Neurons in the Dorsal Root Ganglia, Marie C. Walters, Martha Sonner, Jessica H. Myers, and David ...

... db mice may be related to changes in the enzymatic activity of DA metabolizing enzymes and/or firing pattern of DAergic neurons ...

Once the neuron is damaged or depleted of neurotransmitters, pain perception is notably diminished for a period of time thereby ...

While these data suggest changes in motor neuron excitability may play a contributing factor, there are likely other synaptic ... While these data suggest changes in motor neuron excitability may play a contributing factor, there are likely other synaptic ...