In a proof-of-concept study, a single-tube 23-plex panel was designed to amplify the kinase domains of ALK, RET, ROS1, and MUSK ... In addition, ligand binding transduces signals from the extracellular domain to the cytoplasm in the classical outside-in ... Note that in absence of Hedgehog ligands Ptch inhibits Smo accumulation and activation but upon binding of Hedgehog ligands (by ... Mainly monomeric models using single template modeling have been defined and deposited in the Swiss Model repository (Bienert ...