They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are ... The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases ... Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases ... Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic ...
... mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed ... Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine ... Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. ... mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed ...