JCI - Microglia in Alzheimer's disease
Microglia are brain-resident myeloid cells that mediate key functions to support the CNS. Microglia express a wide range of ... In this Review, the role of microglia in the pathogenesis of AD and the modulation of microglia activity as a therapeutic ... Aβ binds to PRRs, leading to activation of resting microglia. Acutely activated microglia express cytokines, which drive ... Microglia are perpetually engaged in a mutual interaction with the surrounding environment in CNS; thus, diverse microglial ...
JCI - Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
Innate immune functions of microglia isolated from human glioma patients. J Transl Med. 2006;4:15. View this article via: ... Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro-oncology. 2010;12(11):1113-1125.. View this ...
JCI - Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory functions that maintain normal ... For example, microglia clear misfolded proteins, elaborate trophic factors, and regulate and terminate toxic inflammation. In ... Here, we evaluated murine models that recapitulate microglial responses to Aβ peptides and determined that microglia-specific ... Our findings indicate that EP2 signaling suppresses beneficial microglia functions that falter during AD development and ...
JCI - The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
The consequences of Aβ ligation of RAGE appear to be quite different on neurons versus microglia. Whereas microglia become ... Thus, the interaction of Aβ with RAGE on microglia stimulates chemotaxis and expression of cytokines (for example, TNF-α) (27 ...
JCI - Factor XIII activity mediates red blood cell retention in venous thrombi
The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system ...
JCI Insight - Inhibition of astrocyte hemichannel improves recovery from spinal cord injury
Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci. 2006;26(16):4308-4317. ... and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia ...
JCI Insight - Volume 2, Issue 11
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a ... they had no effect either on the population of microglia in the CNS during development or on mobilization of microglia and ... Thus, while Kindlin3 deficiency in human subjects is not expected to diminish the presence of microglia within CNS, it might ... Based on 2-photon imaging of microglia in the brain, Kindlin3 is required for elongation of microglial processes toward the ...
JCI Insight - Welcome
Targeting microglia may thus be a viable strategy to mitigate the development of POCD, particularly in those with increased ... To examine the role of microglia in POCD, we inhibited the colony-stimulating factor 1 receptor (CSF1R) in adult mice, ... In rodents, postoperative cognitive decline (POCD) is associated with the inflammatory activation of hippocampal microglia. ... effectively depleting CNS microglia. Surgical trauma (tibial fracture) reduced the ability of mice to remember a conditioned ...
JCI Insight - Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
Voluntary exercise promotes glymphatic clearance of amyloid beta and reduces the activation of astrocytes and microglia in aged ...
JCI Insight - DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis
Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture. J Neurosci Res. 2008;86( ...
JCI Insight - Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy
Among these microglia subpopulations, we found a highly proliferative microglia subset with high self-renewal capacity and a ... These unique types of microglia have the potential to promote retinal angiogenesis, which may have important implications for ... We have unveiled several unique types of PR-associated microglia (PRAM) and identified markers, signaling pathways, and ... Here, we aimed to investigate the heterogeneity of microglia associated with neovascularization and to characterize the ...
JCI Insight - Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a ... they had no effect either on the population of microglia in the CNS during development or on mobilization of microglia and ... Thus, while Kindlin3 deficiency in human subjects is not expected to diminish the presence of microglia within CNS, it might ... Based on 2-photon imaging of microglia in the brain, Kindlin3 is required for elongation of microglial processes toward the ...
JCI Insight - Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a ... they had no effect either on the population of microglia in the CNS during development or on mobilization of microglia and ... Quantification of pY397 FAK to total FAK ratio in microglia plated on FN that were either stimulated with Mn2+ or left ... Thus, while Kindlin3 deficiency in human subjects is not expected to diminish the presence of microglia within CNS, it might ...
JCI Insight - Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a ... they had no effect either on the population of microglia in the CNS during development or on mobilization of microglia and ... Thus, while Kindlin3 deficiency in human subjects is not expected to diminish the presence of microglia within CNS, it might ... Based on 2-photon imaging of microglia in the brain, Kindlin3 is required for elongation of microglial processes toward the ...
JCI Insight - Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan...
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci. 2014; ...
JCI Insight - Welcome
Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia. ... Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia. ...
JCI Insight - Microbiota, cirrhosis, and the emerging oral-gut-liver axis
... microglia, and neurons (54, 55). The microbiome in cirrhotic patients with HE has been noted to have reduced autochthonous ...
JCI Insight - CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages,...
The underlying mechanism was by blocking the emergence of CD11chiMHCIIhi microglia at peak disease that expressed receptors for ... CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery ... CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery ... CD47 Ab Miap410 reduces phagocytosis-related proteins on microglia in SCs of EAE mice. ...