Frontiers | Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder
Under stress, microglial cells are induced into the M1 type, releasing inflammatory factors and causing neuroinflammatory ... As the immune cells of the central nervous system (CNS), microglia could influence neurogenesis through the M1 and M2 subtypes ... As immune cells of the central nervous system, microglia can influence neurogenesis through different subtypes, and then affect ... The increased IBA1 gene expression measured in the white matter of depressed suicides may indicate further evidence for ...
Frontiers | Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors ... Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors ... We also highlight potential options of targeting senescent cells for the treatment of CKD. ... We also highlight potential options of targeting senescent cells for the treatment of CKD. ...