Chain A, macrophage elastase MMP-12 (human) | Protein Target - PubChem
... macrophage elastase MMP-12 (human). Find diseases associated with this biological target and compounds tested against it in ...
The role of microglia and macrophages in glioma maintenance and progression
The majority of the non-neoplastic cells are tumor-associated macrophages (TAMs), either of p … ... The role of microglia and macrophages in glioma maintenance and progression Nat Neurosci. 2016 Jan;19(1):20-7. doi: 10.1038/nn. ... The majority of the non-neoplastic cells are tumor-associated macrophages (TAMs), either of peripheral origin or representing ...
Helper T Cells and Lymphocyte Activation - Molecular Biology of the Cell - NCBI Bookshelf
They not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, but they also help ... and will activate macrophages to kill microbes located within the macrophages phagosomes. It will also activate cytotoxic T ... They secrete IFN-γ, which binds to IFN-γ receptors on the macrophage surface, and they display the costimulatory protein CD40 ... TH1 Cells Help Activate Macrophages at Sites of Infection. TH1 cells are preferentially induced by antigen-presenting cells ...
Macrophage-mediated inflammation in metabolic disease
The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two ... Here, we discuss how changes in the recruitment and activation of macrophages contribute … ... Macrophage-mediated inflammation in metabolic disease Nat Rev Immunol. 2011 Oct 10;11(11):738-49. doi: 10.1038/nri3071. ... The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two ...
Role of nitric oxide synthesis in macrophage antimicrobial activity
Research over the past 5 years has demonstrated that immunologic activation of mouse macrophages induces the activity of nitric ... Role of nitric oxide synthesis in macrophage antimicrobial activity Curr Opin Immunol. 1991 Feb;3(1):65-70. doi: 10.1016/0952- ... A review of the biochemistry and immunologic regulation of this pathway in macrophages provides a backdrop against which to ... Research over the past 5 years has demonstrated that immunologic activation of mouse macrophages induces the activity of nitric ...
The role of S100B in the interaction between adipocytes and macrophages
S100B as an adipokine may play a role in the interaction between adipocytes and macrophages to establish a vicious paracrine ... The role of S100B in the interaction between adipocytes and macrophages Obesity (Silver Spring). 2014 Feb;22(2):371-9. doi: ... Conclusions: Thus, S100B as an adipokine may play a role in the interaction between adipocytes and macrophages to establish a ... Design and methods: RAW264.7 macrophages (RAW) were stimulated by recombinant S100B to observe alterations in TNF-α and M1 ...
Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice
... Am J Respir Cell Mol Biol. 2016 Jan;54(1):147-9 ...
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection
We found that in primary human macrophages, concentrations of azithromycin achieved during therapeutic dosing blocked ... As a consequence, azithromycin treatment inhibited intracellular killing of mycobacteria within macrophages and resulted in ...
Granulocyte-macrophage colony-stimulating factor and pulmonary surfactant homeostasis
... Proc Assoc Am Physicians. 1998 Jul-Aug; ... Recent work with transgenic mice demonstrated that disruption of the production of granulocyte-macrophage colony-stimulating ... by dysfunction of the alveolar macrophage. Local production of GM-CSF corrects the alveolar proteinosis in the GM-CSF knockout ... by its actions on the clearance of surfactant lipids and proteins by the alveolar macrophage. These findings may have important ...
The macrophage in chronic obstructive pulmonary disease
However, the role of the macrophage in the development of COPD has been controversial. Scientific evidence from a variety of ... Macrophages are the predominant defense cell in the normal lung and during conditions associated with chronic inflammation such ... The macrophage in chronic obstructive pulmonary disease Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 2):S29-32. doi: 10.1164/ ... The role of macrophage proteinases in the development of emphysema, a major component of COPD, will be discussed. Shapiro SD. ...
Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages
However, the mechanisms of macrophage polarization in inflamed joint and its effects on rh … ... Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of ... Knockdown or overexpression of CypA macrophage cells was used to study the functions of CypA on macrophage polarization. ... Moreover, the level of cytokines, such as IL-6, IL-1β, and IL-17, and the number of pro-inflammatory macrophages in synovial ...
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression
Human and murine studies showed high levels of functional PD-L1 expression in dendritic cells and macrophages in the tumor ... Additionally, expression of PD-L1 on dendritic cells and macrophages in ovarian cancer and melanoma patients correlated with ... PD-L1-expressing dendritic cells and macrophages may mechanistically shape and therapeutically predict clinical efficacy of PD- ...
Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis
Macrophages / microbiology* * Mycobacterium tuberculosis / genetics* * Mycobacterium tuberculosis / metabolism* * Mycobacterium ...
Human monocytes express CD163, which is upregulated by IL-10 and identical to p155
Previous reports have indicated that CD163 is highly expressed on human macrophages, but found on less than 50% of peripheral ... Previous reports have indicated that CD163 is highly expressed on human macrophages, but found on less than 50% of peripheral ... In addition, we show that p155 (a previously identified monocyte/macrophage marker of unknown function) shares identity with ...
Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity
These data show distinct gene signature and macrophage abundance in the two compartments of SAT, with dSAT more closely related ... dSAT displayed an intermediate level of macrophage accumulation between sSAT and VAT. The abundance of macrophages in dSAT, but ... Adipose tissue macrophages were quantified by immunohistochemistry using HAM56 antibody in subjects scored for liver ... Conclusions: These data show distinct gene signature and macrophage abundance in the two compartments of SAT, with dSAT more ...
Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
... macrophages, and dendritic cells. Importantly, the absence of SAMHD1 triggered IFN-β-dependent transcriptional upregulation of ...
Advances in mechanisms of systemic lupus erythematosus
... monocytes/macrophages and the inflammasome. Recent advances on B and T cell involvement in the SLE pathogenesis mechanisms are ...
Prenylated Coumarins from the Fruits of Manilkara zapota with Potential Anti-inflammatory Effects and Anti-HIV Activities
10 dispalyed remarkable inhibitory effects against nitric oxide production induced by lipopolysaccharide in mouse macrophage ...
An updated histological classification system for multiple sclerosis lesions
The former is defined by the presence in macrophages of major and small molecular weight myelin proteins, such as cyclic ... Based on the presence/absence and distribution of macrophages/microglia (inflammatory activity) and the presence/absence of ... Inactive lesions are almost completely lacking macrophages/microglia. Active and mixed active/inactive lesions can be further ... Active lesions are characterized by macrophages/microglia throughout the lesion area, whereas mixed active/inactive lesions ...
Growth hormone prevents the development of autoimmune diabetes
... triggered anti-inflammatory macrophage (M2) polarization, maintained activity of the suppressor T-cell population, and limited ...
Pathogenesis of giant cell arteritis: More than just an inflammatory condition?
... which can induce cytokine production by macrophages and fibroblasts. Macrophages in the adventitia produce pro-inflammatory ... including T lymphocytes and macrophages. The pathophysiology of GCA is still poorly understood. After dendritic cell activation ... CD4(+) T lymphocytes, T helper 1 (Th1) cells, produce interferon gamma and modulate macrophage activation and functions, and ...
Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine ...
... induced osteoclast formation was examined using RAW 264.7 macrophage-like cells. RANKL led to the formation of osteoclasts ... However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL- ... induced osteoclast formation was examined using RAW 264.7 macrophage-like cells. RANKL led to the formation of osteoclasts ...
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
... and preceding adipose tissue macrophage (ATM) accumulation and proinflammatory M1 polarization. Mouse 3T3-L1 and primary ...
Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization...
This enhanced type I IFN response inhibited production of the chemokine CCL2, which promotes the recruitment of macrophages and ... Stimulation of CCL2 by macrophages upon pneumococcal infection alone required the pattern recognition receptor Nod2 and ... virus and pneumococcus leads to synergistic stimulation of type I IFNs and that this impairs the recruitment of macrophages, ...
Transcriptional Profiling Uncovers Human Hyalocytes as a Unique Innate Immune Cell Population
Purpose: To decipher the transcriptional signature of macrophages of the human vitreous, also known as hyalocytes, and compare ... Keywords: hyalocytes; immune privilege; innate immunity; myeloid cells; viterous body; vitreous macrophages. ... macrophages and brain microglia obtained from public databases. Protein validation for selected factors was performed by ... it to the profiles of other myeloid cell populations including human blood-derived monocytes, macrophages, and brain microglia ...
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection
... activates the macrophage to traffic M. tuberculosis to the lysosome. How IFNγ elicits this effect is unknown, but many studies ... replicates in macrophages in part by inhibiting phagosome-lysosome fusion, until interferon-γ (IFNγ) ... Furthermore, while Atg5 is dispensable in alveolar macrophages during M. tuberculosis infection, loss of Atg5 in PMNs can ... Mycobacterium tuberculosis, a major global health threat, replicates in macrophages in part by inhibiting phagosome-lysosome ...
Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling...
... expression in colonic macrophages. An in vitro study on cell lines identified that berberine treatment of Raw 264.7 macrophages ...
The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity
Macrophages, Peritoneal / immunology * Male * Mice * Mice, Inbred C57BL * Mice, Mutant Strains * Period Circadian Proteins / ...
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting
... Cell. 2018 Nov 1;175(4):1031-1044.e18 ... Keywords: alveolar macrophages; basophils; cellular interaction; development; immune system; lung; signaling; single-cell RNA ... we show that basophils establish a lung-specific function imprinted by IL-33 and granulocyte-macrophage colony-stimulating ... and co-culture studies show that lung resident basophils are important regulators of alveolar macrophage development and ...
Adipokines in atherosclerosis: unraveling complex roles
Keywords: adipokine; atherosclerosis; endothelial cell; macrophage; vascular smooth muscle cell. © 2023 Luo, He, Li, Lv, Cai, ...