Penicillin ꞵ-lactams. Cephalosporins. Carbapenems. Chloramphenicols. Polymyxins. Nitrofurans. Sulfonamides. Tetracyclines. ... pneumoniae strain was resistant to all of the beta-lactams tested, trimethoprim/sulfamethoxazole and minocycline and had ...

... with high levels of resistance to β-lactams, aminoglycosides and tetracycline. Ten resistance genes were detected, the most ... Genes for resistance to quinolones (gyrA and parC), β-lactams (ampC), chloramphenicol (cmlA), streptomycin (aadA), gentamicin ( ... Genes for resistance to quinolones (gyrA, parC), β-lactams (ampC), chloramphenicol (cmlA), streptomycin (aadA), gentamicin (aac ... Genes for resistance to quinolones (gyrA, parC), β-lactams (ampC), chloramphenicol (cmlA), streptomycin (aadA), gentamicin (aac ...

Synthesis of a β-lactam from a vinylaziridine through insertion of carbon monoxide was published in 1993 (Equation 1 in Scheme ... Tanner, D.; Somfai, P. Palladium-catalyzed transformation of a chiral vinylaziridine to a β-lactam. An enantioselective route ... the so-formed π-allyl complex 6 is dominantly and quickly converted to β-lactam 8 (Equation 3 in Scheme 3), but when the ... Stereoselective synthesis of trans-beta-lactams by palladium-catalysed carbonylation of vinylaziridines. Chem. Commun. 2010, 46 ...

Shi, S.; Lalancette, R.; Szostak, R.; Szostak, M. Highly Chemoselective Synthesis of Indolizidine Lactams by SmI2-Induced ... The functional group tolerance is very broad, including halides (Br, Cl), esters, lactams, highly electron-deficient and ... The product indolizidine and quinazolidine lactams are of particular significance in medicinal chemistry and natural product ... Scheme 7. Synthesis of Lactams via Ionic Cyclization of N-Tethered Iodoalkyl Cyclic Imides. ...

Definition of the antibiotic biosynthetic genes and evidence for a novel β-lactam resistance mechanism. Mol. Microbiol. 1997, ... Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway. Mol. Microbiol. ...

Lactams, aminoglycosides, fluoroquinolones, macrolides, and tetracyclines. Excessive use and continuous exposure to antibiotics ...

... intensifiers of beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2005, ...

... beta-lactam cefixime and ciprofloxacin [11,12,13]. The same team prepared modified adsorbents from laterite soil and used them ... Adsorption characteristics of beta-lactam cefixime onto nanosilica fabricated from rice HUSK with surface modification by ...

This retrospective single-center study evaluated a cohort of patients treated with two new associations of β-lactam/β-lactamase ... Moreover, the new β-lactam/β-lactamase inhibitors should be considered in severe CRE infections [10]. Ceftazidime/avibactam has ... The increase in infections due to ESBL-positive Enterobacterales induced an increased use of β-lactams and penicillins ... Van Duin, D.; Bonomo, R.A. Ceftazidime/avibactam and ceftolozane/tazobactam: Second-generation β-lactam/β-lactamase inhibitor ...

... antibiotics such as beta-lactams, clindamycin and fluoroquinolones tend to get eliminated through the posterior route [3,29,30 ...

Avershina, E. AMR-Diag: Neural Network based Genotype-to-Phenotype Prediction of Resistance towards Beta-Lactams and Colistin ...

Grochla, I.; Ko, H.L.; Beuth, J.; Roszkowski, K.; Roszkowski, W.; Pulverer, G. Effects of beta-lactam antibiotics imipenem/ ... such as beta-lactam, except for direct antimicrobial effects also act as neuromodulators due to the upregulation of the ...

Studies using the β-lactam amoxicillin, an inhibitor of transpeptidation in cell wall synthesis, support a role for bacterial ...

Although high rates of resistance to beta-lactams have been found among pathogens causing PJI [8,10,38,46], particularly CoNS, ... and vancomycin in cases of beta-lactam allergy, are the antibiotics most commonly used and recommended in current guidelines, ... despite the fact that methicillin resistance implies resistance to all beta-lactams, cephalosporins included). Moreover, an SBT ...

For example, cationic aminoglycosides are trapped by the negatively charged polymers of the biofilm matrix, the beta-lactams, ...

Beta-lactams Overall, beta-lactams are a class of antibiotics characterized by a very short half-life (from 0.5 h of several ... ICU patients with expected beta-lactam PK variability and/or patients with clinical signs potentially related to beta-lactam ... Thabit, A.K.; Hobbs, A.L.V.; Guzman, O.E.; Shea, K.M. The Pharmacodynamics of Prolonged Infusion β-Lactams for the Treatment of ... If it is important to preserve the activity of "old" molecules, it is much more important to preserve the new beta-lactam/beta- ...

... beta-lactams; betalactamases; protein export; two-component systems. ...

The objective of this study was to investigate the genetic basis for declining susceptibility to penicillin and other β-lactams ... This study found that a growing trend of isolates displayed reduced susceptibility to β-lactams including penicillin, ... of which 18 substitutions were most statistically associated with reduced β-lactams susceptibility. Almost all the S. suis ... that there was genetically widespread presence of PBPs substitutions associated with reduced susceptibility to β-lactam ...

Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus. Previous Article in Special Issue. Diverse ... Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam ...

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049 by Xiuli Xu ... Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of ... Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of ...

Vardakas, K.Z.; Kalimeris, G.D.; Triarides, N.A.; Falagas, M.E. An update on adverse drug reactions related to β-lactam ... in patients treated with vancomycin alone or in combination with other beta-lactams [47]. Several reasons might explain the ... Comparison of acute kidney injury and clinical prognosis of vancomycin monotherapy and combination therapy with beta-lactams in ...

Anyanwu, M.U.; Ezekwelu, M.O.; Okorafor, O.N. Prevalence and Antibiogram of Generic Extended-Spectrum β-Lactam-Resistant ...

However, the reason for the good result for β-lactam antibiotics was clearly established, which was that the active centers of ... The best result for the catalytic activity of His6-OPH/PLD50 was obtained with the β-lactam antibiotic ampicillin. ... The entrapment of EPC with an antimicrobial agent (β-lactam antibiotic or antimicrobial peptide) into the poly(vinyl alcohol) ... the greatest positive effect was achieved for β-lactam antibiotics, such as ampicillin and meropenem [19,64]. Such variants ...

For patients unable to take both doxycycline and beta-lactam antibiotics, the preferred second-line agent is azithromycin [12 ...

... a scoping review noted that β-lactam antibiotics (more specifically, penicillin and aminopenicillin/β-lactamase inhibitors) are ...