Interferon-γ induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1- ... Defective binding of IRFs to the initiator element of interleukin-1β-converting enzyme (ICE) promoter in an interferon- ... 6⇓, lane 6 vs 2 or 4) and SW620 cells (Fig. 6⇓, lane 12 vs 8 or 10). SW480 or SW620 cells transfected with the empty vector as ... 4⇓). As with the human colon carcinoma studies (Fig. 3⇑), we found a very similar pattern of expression of ICSBP and caspase-1 ...

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral ... 4⇑A), implying that a few MBP-specific T cells could play overwhelming roles in certain phases of MS. Together with the fact ... FIGURE 4. SSCP profiles of CD3+CD25+ population from patient IS with secondary progressive MS. A, January 1997. Note the ... 4⇑B). Similarly, the number and distribution of the SSCP bands varied among samples from patient OK (Table III⇑). ...

... dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat. Med. 15: 42-49. ... 4-6, sepsis in both SR-BI/II and CD36 KO mice was less severe than in control mice. SR-BI/II KO animals received dexamethasone ... 4). Total plasma cholesterol and triacylglycerol were not changed in any of the three groups of mice after CLP (Fig. 5A, 5B). ... FIGURE 4. Systemic inflammation reduced in septic scavenger receptor-deficient mice (CD-36 and SR-BI/II deficiency). Serum ...

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat. ... 4A, both WT and Smad3 KO mice developed similar diseases at day 7-24 after immunization. Immunization of both WT and Smad3 KO ... 4B, 4C). These results demonstrate that the SMAD3 pathway plays no essential role in Th17 cell differentiation in vivo or in ... FIGURE 4. The absence of Smad3 gene does not alter IL-17 production in vivo, nor does it affect the development of Th17- ...