A recent publication has shown that this is due to the early release of interleukin-1α (IL-1α) from lung epithelial cells that ... This IL-1α acts as a promoting factor that stimulates the production of IL-1β and of a further cytokine storm from alveolar ... Anakinra is the only marketed product that inhibits both IL-1β and IL-1α and hence it is able to block an inflammatory response ... Change of SOFA score in enrolled subjects between days 1 and 7 [ Time Frame: Visit study day 1, visit study day 7 ]. Change of ...