Viruses | Free Full-Text | Mutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness...
... can cause severe courses of infection in pregnant women and immunosuppressed patients. To date, HEV infections can only be ... viral extinction versus selection of fitness-enhanced viruses. Following an overview of RNA viruses treated with RBV in clinics ... Emergence of these mutant viruses can lead to therapeutic failure. Consequently, the onset of RBV treatment in chronically HEV- ... In contrast, the expanded heterogeneous viral population can facilitate selection of mutant viruses with enhanced replication ...