We then set up the CANARI study focusing on men with symptoms and complications related to benign prostatic hypertrophy. ... Use of 5?-reductase inhibitors for benign prostatic hypertrophy and risk of high-grade prostate cancer: A French population- ... should be considered when managing long-term treatment for symptomatic benign prostatic hypertrophy. ... in Brittany with at least one reimbursement for a drug licensed for symptomatic or complicated benign prostatic hypertrophy (5- ...