Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor...
p , 0.05 compared with control (ANOVA); n = 4. g, Spinal injection of IL-1β, TNFα, and IL-6 (10 ng) induces heat hyperalgesia ... a-f, Induction of CREB phosphorylation and heat hyperalgesia by PICs. a-d, pCREB immunostaining in the superficial dorsal horn ... Injection of all three PICs (10 ng) into spinal cord CSF induced marked heat hyperalgesia, as shown by a decrease in PWLs (Fig ... However, the overall effect of sIL-6R is pronociceptive, because it induced pCREB at 30 min and heat hyperalgesia at 30-120 min ...
Plus it
2014) Stress-induced hyperalgesia. Prog Neurobiol doi:10.1016/j.pneurobio.2014.06.003. doi:10.1016/j.pneurobio.2014.06.003, ... 2012) Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain 153:2204-2209, doi:10.1016/j.pain.2012.06 ... 2011) Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to ... 2011) Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic ...
PKA/AKAP/VR-1 Module: A Common Link of Gs-Mediated Signaling to Thermal Hyperalgesia | Journal of Neuroscience
PKA/AKAP/VR-1 Module: A Common Link of Gs-Mediated Signaling to Thermal Hyperalgesia. Parvinder Kaur Rathee, Carsten Distler, ... We conclude that the PKA/AKAP/VR-1 module represents the molecular target of Gs-coupled receptors to cause thermal hyperalgesia ... A number of inflammatory mediators that cause inflammatory pain and hyperalgesia exert their effect via Gs-coupled membrane ... Thus, the PKA/AKAP/VR-1 module presents as the molecular correlate of Gs-mediated inflammatory hyperalgesia. ...
Plus it
1991) Peripheral mechanisms of sensitization and hyperalgesia. in Anesthesiology and pain management, eds Stanley T, Ashburn M ... 1992) The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107:660- ... 1994) The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine-induced mechanical hyperalgesia in the rat. Br J ... 1989) Inhibition by neuropeptides of interleukin-1β-induced, prostaglandin-independent hyperalgesia. Br J Pharmacol 98:41-43. ...
Plus it
To examine mechanical hyperalgesia induced by capsaicin in the hairy skin, capsaicin (3 μg/5 μl) was injected into the central ... To measure secondary hyperalgesia, mechanical thresholds in response to von Frey filaments were determined at regions adjacent ... 1991) Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol 66:190-211. ... 1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77-88. ...
Plus it
We measured mechanical hyperalgesia in rats by testing the withdrawal threshold in response to a noxious pressure stimulus ( ... Behavioral assessment of tactile allodynia and hyperalgesia in rats.. To quantify tactile allodynia, rats were placed in ...
Plus it
... and a role in cold hyperalgesia (Katsura et al., 2006). Two recent reports of TRPA1 knock-out models, in which only a portion ... alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol 200:112-123. ... A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77-88. ... Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in ...
Plus it
... abolished Taxol-induced mechanical hyperalgesia and attenuated hypotonic hyperalgesia by 42%. The enhancement of osmotic ... 3A). Injection of GRGDTP totally reversed Taxol-induced mechanical hyperalgesia (0.45 ± 2.1, n = 6 after vs 35.6 ± 1.7, n = 12 ... Taxol-induced mechanical hyperalgesia and hypotonicity-induced nociception are mediated by TRPV4. A, Taxol-induced mechanical ... Integrins play a role in Taxol-induced mechanical hyperalgesia (Dina et al., 2004) and also have been proposed to be involved ...
A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve...
NGF acutely or chronically administered to animals and man can produce pain and hyperalgesia (Lewin et al., 1993; Petty et al ... 1993) Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci 230:2136-2148. ... 1995) Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the ...
Plus it
2000) ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia. Brain 123: ...
Plus it
Contribution of interleukin-1β to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia ...
Table of Contents - June 15, 2000, 20 (12) | Journal of Neuroscience
Extensive Sprouting of Sensory Afferents and Hyperalgesia Induced by Conditional Expression of Nerve Growth Factor in the Adult ...
Table of Contents - September 22, 2010, 30 (38) | Journal of Neuroscience
Low Nociceptor GRK2 Prolongs Prostaglandin E2 Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase Cε, and MEK/ ...
Neurobiological Mechanisms of the Placebo Effect | Journal of Neuroscience
It was found that verbally induced expectations of analgesia/hyper-algesia and of motor improvement/worsening antagonized ...
adenylate cyclase | Journal of Neuroscience
Phosphorylation of CREB and Mechanical Hyperalgesia Is Reversed by Blockade of the cAMP Pathway in a Time-Dependent Manner ...
Plus it
... either produced hyperalgesia or had little or no antinociceptive action (Meunier et al., 1995; Reinscheid et al., 1995). We ...