No overt behavioral phenotypes were observed in homozygotes throughout adulthood (≤2 years of age). Animals were housed on a 12 ...

NM HC nuclei of gemtc123d and gemtn004 homozygotes were indistinguishable from those of wild-type larvae because no obvious ... In cav1.3a cDNAs from gemtc123d homozygotes, we identified a C → T transition at nucleotide 3970 exchanging an Arg codon (CGA, ... RT-PCR and in situ hybridization indicated that cav1.3a mRNA levels are normal in tc123d homozygotes (data not shown). This ... Mutational analysis. Total RNA extracts from at least three independent batches of tc123d and tn004 homozygotes and from their ...

3A,B). This suggested that dgq221c homozygotes would be devoid of zygotic Gqα protein. To verify this, the level of Dgqα3 was ... 3). We attribute the low level of Dgqα3 seen in the mutant homozygotes to a maternal contribution. However, this has not been ... the intensity of the band corresponding to Dgqα3 was considerably reduced in dgq221c homozygotes on comparison with the level ...

... in homozygotes the EGL is interrupted (bottom, arrowhead), and clusters of ectopic cells (bottom, arrows) are seen outside the ... cerebella at P0.5 show defects in the rostral region in homozygotes, with lobules I-III most severely affected. B-E, Analysis ... was malformed in all homozygotes (Fig. 1A) (n = 14). The defects, which included fusion of adjacent lobules, disruption of ... but severely fragmented in homozygotes (bottom). F, Electron microscopy of lobules I-III in E19.5 cerebella shows the earliest ...

... mice showed that β1 mRNA is significantly reduced in the heterozygotes and completely absent in the homozygotes (Fig. 1E). β1 ...

As homozygotes,egl-2(sa236) and other members of this class of revertants appear wild-type, having no gross defects in movement ...