Antiretrovirals, Fractures, and Osteonecrosis in a Large European HIV Cohort - CROI Conference
In HIV infection, host factors, HIV-specific variables and co-morbidities contribute to risk of fractures and osteonecrosis. ... Alvaro H. Borges1; Jennifer Hoy2; Eric Florence3; Dalibor Sedlacek4; Hans-Jürgen Stellbrink5; Vilma Uzdaviniene6; Tomazic Janez ... 1Rigshospitalet, Univ of Copenhagen, Copenhagen, Denmark;2Alfred Hosp, Melbourne, Australia;3Inst of Trop Med Antwerp, Antwerp ... 7; Panagiotis Gargalianos-Kakolyris8; Jens D. Lundgren1; Amanda Mocroft9; for the for EuroSIDA in EuroCOORD. ...
Virological Remission After ART Interruption in African HIV-1 Seroconverters - CROI Conference
... in primary HIV infection (PHI). We present the first analysis of treatment interruption (TI) in individuals with PHI in Africa ... CD4 T cell count and Total HIV-DNA were similar in UK and African patients, although Integrated HIV-1 DNA was lower in the ... We analysed samples from those randomised to no treatment (NT) and 48 weeks of ART (ART48). We measured HIV-1 DNA in CD4 T ... Measured pre-ART, Total HIV-1 DNA, VL and CD4 count in Africans were associated with clinical progression (p=0.001, HR (CI95) ...
PEMBROLIZUMAB INDUCES HIV LATENCY REVERSAL IN HIV+ INDIVIDUALS ON ART WITH CANCER - CROI Conference
In HIV-infected individuals on suppressive antiretroviral therapy (ART), HIV is enriched in CD4 T-cells that express PD-1. ... prospectively evaluated markers of HIV persistence to test the hypothesis that pembrolizumab administration might increase HIV ... Pembrolizumab is a monoclonal antibody against PD-1 approved for several cancers. ... Plasma HIV RNA was measured using a single copy (sc) qRT-PCR for HIV gag. Intracellular unspliced (us) HIV RNA (RNA) and viral ...
SCREENING FOR PRECANCEROUS ANAL LESIONS WITH P16/KI67 DUAL STAIN CYTOLOGY IN HIV - CROI Conference
Anal cancer is among the most prevalent neoplasias in HIV-infected MSM. Screening with anal citology results yields to high ... Anal cancer is among the most prevalent neoplasias in HIV-infected MSM. Screening with anal citology results yields to high ... A total of 328 HIV-infected MSM underwent 386 full examinations. Mean age was 39±10 years, median nadir CD4 367 (258-510) cells ... Prospective multi-center cohort study in 6 HIV clinics. Concomitant anal liquid cytology with p16/Ki-67 dual staining (CINtec® ...
COVID-19 VACCINATION RATES IN A GLOBAL HIV COHORT - CROI Conference
Little is known regarding global COVID-19 vaccination rates in people with HIV (PWH), a population with significant morbidity ... Little is known regarding global COVID-19 vaccination rates in people with HIV (PWH), a population with significant morbidity ... and HIV-specific data were compared among those vaccinated vs not via Kaplan-Meier. ... Evelynne S. Fulda1, Kathleen Fitch1, Edgar T. Overton2, Markella V. Zanni1, Judith A. Aberg3, Judith S. Currier4, Michael T. Lu ...
PATIENTS EXPERIENCING VIRAEMIA IN ADHERENCE CLUBS: IS BACK-TO-CLINIC ALWAYS BEST? - CROI Conference
We included data on all patients ever in a club at three large primary healthcare clinics in Khayelitsha, a high HIV-prevalence ... Tali Cassidy1, Jonathan Euvrard1, Claire Keene2, Erin Roberts3, Rodd Gerstenhaber4, Andrew Boulle1 ... and before 1 October 2017. We describe characteristics of these patients at the time of the unsuppressed VL test result, ... Table 1). A multivariate logistic regression showed 12-month VL resuppression was associated with remaining in clubs after one ...
Pragmatic Open-Label Randomised Trial of Preexposure Prophylaxis: The PROUD Study - CROI Conference
... increasing their chance of exposure to HIV and other STIs. This supports the need for ... reduces the risk of HIV infection. However, there are concerns that this benefit might be counteracted by users of PrEP ... 20 MSM (5 IMM, 15 DEF) had no HIV test after baseline; completeness of follow-up for HIV incidence was 91% (237/261 PY) for IMM ... Three HIV infections were observed in IMM (1.3/100 PY); 19 infections were observed in DEF (8.9/100 PY) despite 174 ...
COVID-19 PANDEMIC IMPACT ON HIV PrEP PROGRAM ENGAGEMENT IN BRITISH COLUMBIA - CROI Conference
We examined client engagement in BCs province-wide, publicly-funded HIV PrEP program before and during the COVID-19 pandemic. ... We examined client engagement in BCs province-wide, publicly-funded HIV PrEP program before and during the COVID-19 pandemic. ... Continued evaluation will facilitate understanding the pandemic impact on HIV prevention programming. ... COVID-19 PANDEMIC IMPACT ON HIV PrEP PROGRAM ENGAGEMENT IN BRITISH COLUMBIA. ...
Higher Cumulative TFV/FTC Levels in PrEP Associated With Decline in Renal Function - CROI Conference
PrEP is proven to reduce the risk of HIV acquisition. Drug levels (as markers of adherence) have been critical to interpreting ... PrEP is proven to reduce the risk of HIV acquisition. Drug levels (as markers of adherence) have been critical to interpreting ... The iPrEx Open Label Extension (OLE) study enrolled HIV-negative MSM and transwomen and all were on PrEP. Hair samples were ... Establishing thresholds of TFV/FTC exposure that protect from HIV, but minimize the risk of toxicity, is essential to the real- ...