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Hence, a histone modification signature (i.e., Suv39h1-mediated methylation of H3K9) acts as an early safeguard against ... Indeed, the identification of a common epigenetic signature of histone H3K9 methylation and subsequent HP1-γ binding in ... Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 2000; 406: 593-9. ... we investigated a putative mechanism in which the Rb-bound histone methyltransferase Suv39h1 links the Rb pathway to ...
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The activation of β-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors. Exp Cell Res 2007; 313: ...
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The samples were incubated overnight at 4°C with a phosphorylated histone H3 antibody (Santa Cruz Biotechnology). After three ...
Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer | Cancer Research
Evaluation of cell viability by MTT (A) and histone DNA ELISA for apoptosis (B) by thymoquinone treatment for 72 h. *, P , 0.05 ... B, increased apoptosis in pancreatic cancer cells by histone-DNA ELISA relative to untreated control or monotherapy treatment. ... we evaluated apoptosis using histone-DNA ELISA. Figure 1B shows a significant increase in apoptotic cells, which closely ...
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Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl. Acad ... Lee B. I., Park S. H., Kim J. W., Sausville E. A., Kim H. T., Nakanishi O., Trepel J. B., Kim S. J. MS-275, a histone ... 1A ⇓ . MS-275 exhibited marked HDAC activity, inducing a sharp increase in acetylation of histones H3 and H4 at all of the ... Jaboin J., Wild J., Hamidi H., Khanna C., Kim C. J., Robey R., Bates S. E., Thiele C. J. MS-27-275, an inhibitor of histone ...
Tumor Cell Senescence in Cancer Treatment | Cancer Research
This effect is mediated through the activation of transcription cofactors/histone deacetylases p300 and CBP, which augment not ...
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... a known inhibitor of histone deacetylase, resulted in increased histone H4 acetylation and IGFBP-2 secretion in Caco-2 cells. ... a connection between histone acetylation and IGFBP-2 secretion was found in this study: both butyrate and trichostatin A, ...
Table of Contents | Cancer Research
Cancer Cells Become Susceptible to Natural Killer Cell Killing after Exposure to Histone Deacetylase Inhibitors Due to Glycogen ...