Nor C, Sassi FA, de Farias CB, Schwartsmann G, Abujamra AL, Lenz G, Brunetto AL, Roesler R. The histone deacetylase inhibitor ... HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia. Biol Chem. 2013;394(4):519-28. ... Active ATM phosphorylates downstream targets including the histone variant H2AX and Chk2, ultimately resulting in repair of the ...

Histone modification in NSCLC: molecular mechanisms and therapeutic targets. Int J Mol Sci. 2021;22:11701. ...

phosphorylated isoform of the histone variant H2AX. References. *. Desandes E, Lacour B, Belot A, White-Koning M, Velten M, ...

H1.2 linker histone, is also called HIST1H1C. Li et al. reported that inhibition of H1.2 phosphorylation at T146 was related to ...

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha. Cell. 2013;153(3):590-600 ... Chen R, Zhao W-Q, Fang C, Yang X, Ji M. Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers. J ... SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep. ... The SET domain containing 2 histone lysine methyltransferase (SETD2) gene encodes the functional domain of an enzyme that ...

Dysfunction of histone methylation was also shown to contribute to human carcinogenesis [22]. Interestingly, genes involved in ...

Tapia C, Kutzner H, Mentzel T, Savic S, Baumhoer D, Glatz K: Two mitosis-specific antibodies, MPM-2 and phospho-histone H3 ( ... Juan G, Traganos F, James WM, Ray JM, Roberge M, Sauve DM, Anderson H, Darzynkiewicz Z: Histone H3 phosphorylation and ... In 1997, the mitosis marker anti phosphohistone H3 was first introduced [14]. Phosphorylation of histone H3 (Ser 10) is shown ... Simon JA, Lange CA: Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008, 647 (1-2): 21-29. ...

In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer ... In addition to its effects on histone modifications, garcinol was found to block CBP/p300-mediated acetylation of the C- ... Drug-like molecules that can reprogram selected histone PTMs in tumour cells are therefore of interest as potential cancer ... In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these ...

Cytoplasmic histone-associated DNA fragments were determined using cell death detection kit. The data represents mean ± SD of ... Briefly, cytoplasmic histone associated DNA fragments from control or Triphala treated cells were extracted and incubated in ... Martirosyan A, Leonard S, Shi X, Griffith B, Gannett P, Strobl J: Action of a histone deacetylase inhibitor NSC3852 (5-nitroso- ... experiments were carried out to measure the levels of cytoplasmic histone associated DNA fragments using cell death detection ...

The p.Arg215Trp variant, suggested to impair NBN binding to histone γ-H2AX, was observed in one breast cancer case and one ... The p.Arg215Trp variant, suggested to impair NBN binding to histone γ-H2AX, was observed in one breast cancer case and one ... and these domains have been demonstrated to be essential to NBN binding to the histone γ-H2AX [34, 35]. One of the rare ...

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal ...

Cell cycle distribution and phosphorylation of histone variant H2AX as a surrogate marker for DNA damage was quantified by flow ... Cell cycle distribution and phosphorylation of histone variant H2AX as a surrogate marker for DNA damage was quantified by flow ... Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in ... phosphorylation of histone variant H2AX (γH2AX) serves as a key mediator for the assembly of DNA repair proteins at the sites ...

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. Embo J. 2010;29(9): ...

A correlation between YAP and the CIN marker phospho-H2A histone family member X (pH2AX) was particularly observed in tissues ... A correlation between YAP and the CIN marker phospho-H2A histone family member X (pH2AX) was particularly observed in tissues ...

Arion D, Meijer L, Brizuela L, Beach D: Cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity ... and the M-phase specific histone H1 kinase [25]. Furthermore, CDC2 also plays a role in phosphorylating the retinoblastoma gene ...

Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci. 2010;107:21931-6. ... Lysine acetylation in histones is recognized by Bromodomain and Extraterminal (BET) proteins through epigenetic reader domains ... SEs are typically enriched in acetylation at histone 3 lysine 27 (H3K27Ac) [19], a hallmark of open chromatin that allows DNA ... Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4. J Biol ...

Genistein Affects Histone Modifications on Dickkopf-Related Protein 1 (DKK1) Gene in SW480 Human Colon Cancer Cell Line. Plos ...

Sera from patients with SLE frequently exhibit a homogeneous pattern and anti-dsDNA or anti-histone antibodies [18,20]. ... we have detected anti-histone antibodies in BC sera by immunoscreening a cDNA library of BC proteins with BC sera [unpublished ...

... and set up a histone chart model to predict progression-free intervals of 1, 3, and 5 years. We identified eight ERDEGs that ...

Shen WF, Krishnan K, Lawrence HJ, Largman C. The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol ... as well as transcriptional inhibitors such as histone deacetylase (HDAC), resulting in differential gene regulation depending ...

Furthermore, cisplatin induced changes in histone acetylation, phosphorylation and methylation of histone H3 in mammary tumours ... Suggesting, PPAR-γ directly or indirectly alters aberrant gene expression in mammary tumours by changing histone modifications ... Posttranslational modifications of histone H3, mitogen-activated protein (MAP) kinase p38 expression and PPAR-γ expression were ... Phosphorylation of histone H3 is known to be involved in cell proliferation. Decrease in histone H3 phosphorylation and ...

Piekarz RL, Sackett DL, Bates SE: Histone deacetylase inhibitors and demethylating agents: clinical development of histone ... Dokmanovic M, Clarke C, Marks PA: Histone deacetylase inhibitors: Overview and perspectives. Mol Cancer Res. 2007, 5: 981-989. ... deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells. Intl J Cancer. 2003, 103: 177-184 ... such as histone deacetylase inhibitors, are warranted [38-41]. ...

For instance, the histone deacetylase (HDAC) inhibitor, SAHA, is a strong autophagy inducer and also initiates caspase- ... Gammoh N, Lam D, Puente C, Ganley I, Marks PA, Jiang X. Role of autophagy in histone deacetylase inhibitor-induced apoptotic ... Shao Y, Gao Z, Marks PA, Jiang X. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad ... Life or death? Autophagy in anticancer therapies with statins and histone deacetylase inhibitors. Autophagy. 2011;7(1):107-8. ...

Class 1 histone deacetylases (HDAC) seem to be most important during carcinogenesis. The immunhistochemical expression of HDAC1 ... An increased deacetylation of histones leads to increased cell proliferation, cell migration, angiogenesis and invasion. ... the role of epigenetic alterations including modifications of the acetylation status of histones in carcinogenesis has been an ... Müller, B.M., Jana, L., Kasajima, A. et al. Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast ...

... and a number of histone genes, all of which clustered together. The central part of this proliferation cluster, including PCNA ... alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Res. ...

Muto S, Senda M, Akai Y, Sato L, Suzuki T, et al: Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone ...

Histone acetyltransferases (HATs) of the MYST family are associated with a variety of human cancers. However, the relationship ... The Histone acetyltransferases (HATs) of the MYST family are highly conserved from yeast to humans and function exclusively in ... Histone acetyltransferases (HATs) of the MYST family are associated with a variety of human cancers. However, the relationship ... Liang, F., Li, X., Shen, X. et al. Expression profiles and functional prediction of histone acetyltransferases of the MYST ...

Co-immunoprecipitation indicates that BCORL1 interacts with class II histone deacetylases, such as HDAC4, HDAC5 and HDAC7 [10 ...

Li Q, Wang X. Polycomb CBX7 Directly Controls Trimethylation of Histone H3 at Lysine 9 at the P16 Locus. PLoS One. 2010;5(10):1 ...

... cells were lysed and the extracted cytoplasmic nucleosomal DNA was captured in ELISA wells containing anti-histone antibodies. ...