High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer
Clusterin, a chaperone protein upexpressed in prostate cancer, stabilizes Ku70/BAX complexes, sequestering BAX from its ability ... Low acetylation of histones, observed during apoptosis, causes a hypercondensation of chromatin and the irreversible HMGB1 ... T. Osmanov, I. Ugrinova, and E. Pasheva, "The chaperone like function of the nonhistone protein HMGB1," Biochemical and ... S. Yusein-Myashkova, I. Ugrinova, and E. Pasheva, "Non-histone protein HMGB1 inhibits the repair of cisplatin damaged DNA in ...
Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and...
Enhancer of zeste homolog 2 is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by the EZH2 gene which ... Member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. ... Ι histone deacetylases," Carcinogenesis, vol. 34, no. 7, pp. 1442-1449, 2013. ...
Adjudication of the Alleged Role of Vitamin D in the Antimicrobial Pathway
Together with the SRC complexes, histone acetylases and methyltransferases disrupt the stability of DNA, which allow ... D3 does not appear to be a random process as members of the heat shock protein 70 family act as intracellular chaperones that ...
The Chondroprotective Role of TMF in PGE2-Induced Apoptosis Associating with Endoplasmic Reticulum Stress
S.-A. Yoo, S. You, H.-J. Yoon et al., "A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis," The ... "Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification," The Journal of Biological Chemistry, vol ... On the other hand, GRP78, an endoplasmic reticulum chaperone, plays an important protective role in protein processing and ... XBP1 and the chaperone GRP78 exhibit prosurvival functions to promote protein processing and provision during ERS. GSK-3β, ...
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/ ... 2. Mitochondrial Chaperones and Proteases: Repair/Refold and Recycle. 2.1. Chaperones. The mitochondrial proteome is composed ... treatment induces the accumulation of histone deacetylase 6 (HDAC6) in the mitochondrial outer membrane. p62/SQSTM1 and HDAC6 ... 2.1.1. The Hsp90-Type Chaperone TRAP1. TRAP1, also known as Hsp75, was initially identified as an Hsp90-like chaperone that ...
Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection
... bimethylation of lysine 9 of histone 3; H3K4me1, monomethylation of lysine 4 of histone 3; H3K4me2, bimethylation of lysine 4 ... Cell Stress and Chaperones, vol. 21, no. 4, pp. 571-582, 2016. ... G. Yang, X. Weng, Y. Zhao et al., "The histone H3K9 ... Potential regulation of histone methylation/demethylation underlying MIRI. (a) MIRI can cause increased cardiac H3K9me3 at the ... Evidence also suggests that methylation/demethylation of histone may be crucial for the treatment of MIRI, as well as for the ...
Involvement of Nrf2 in Ocular Diseases
Normally, α-crystallin works as a chaperone protein that supports lens structure, prevents protein aggregation, and maintains ... P. Tokarz, K. Kaarniranta, and J. Blasiak, "Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment ... role of histone methylation," Investigative Ophthalmology & Visual Science, vol. 54, no. 1, pp. 244-250, 2013. ... water-soluble chaperones that aggregate closely together to increase refraction and maintain clarity [106]. ...