Spectrum of Chemically Induced Mutations From a Large-Scale Reverse-Genetic Screen in Arabidopsis | Genetics
At -1 and +1, purines were in excess, with adenines slightly favored over guanines; at -2, guanines were deficient; and at +2, ... As expected for alkylation of guanine by EMS, ,99% of mutations are G/C-to-A/T transitions. A nearest-neighbor bias around the ... EMS mutagenesis delivers ,99% G/C-to-A/T transition mutations: EMS alkylates guanine residues, producing O6-ethylguanine, which ... guanines were in excess, with other weaker biases detected at these positions. For Drosophila, Bentley et al. (2000) described ...
Molecular Genetic Dissection of Mouse Unconventional Myosin-VA: Tail Region Mutations | Genetics
1992 Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene. Nucleic Acids Res. 20: ...
A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis...
2010 The guanine exchange factor vav controls axon growth and guidance during Drosophila development. J. Neurosci. 30: 2257- ... 2005 The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell 123: 119-132. ... We describe a novel role for VAV-1, a conserved guanine nucleotide exchange factor (GEF) for Rho-family GTPases, in regulation ... Previously, we demonstrated that VAV-1, an evolutionarily conserved guanine nucleotide exchange factor (GEF) for Rho-family ...
Extragenic Suppressors of Loss-of-Function Mutations in the Aspergillus FlbA Regulator of G-Protein Signaling Domain Protein |...
Casey P.J.,Gilman A.G., Sefton B. M., 1987 Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proc ... 1992 Influence of γ subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes. Mol. ...
Table of Contents | Genetics
Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in ...
Multiple Pathways Act Together To Establish Asymmetry of the Ventral Nerve Cord in Caenorhabditis elegans | Genetics
Several axon guidance pathways converge on unc-34, encoding the actin modulator Ena/VASP, and unc-73, encoding a guanine ... 2016 Pioneer axon navigation is controlled by AEX-3, a guanine nucleotide exchange factor for RAB-3 in Caenorhabditis elegans. ... Sequencing revealed a guanine to adenine missense mutation in unc-52(hd133), leading to a cysteine to tyrosine change at amino ... coding regions revealed a guanine to adenine base pair change, changing a tryptophan into a stop codon within the predicted ...
A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in...
ASC1 encodes a core component of the 40S ribosomal subunit, which acts as a guanine nucleotide dissociation inhibitor for Gpa2 ...
Statistical Analysis of Pathogenicity of Somatic Mutations in Cancer | Genetics
T implies that a cytosine nucleotide is replaced by an adenine on one DNA strand and a guanine is replaced by a thymine on the ...
Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers | Genetics
Simon, M. A., D. D. L. Bowtell, G. S. Dodson, T. R. Laverty and G. M. Rubin, 1991 Ras1 and a putative guanine nucleotide ...
Genetic Analysis of the Caenorhabditis elegans MAP Kinase Gene mpk-1 | Genetics
... the guanine nucleotide exchange factor SOS and the protein kinase pp90Rsk (reviewed in Ferrell 1996). ...
The Ketel Gene Encodes a Drosophila Homologue of Importin-β | Genetics
... the guanine nucleotide exchange factor for Ran, and promotes the association of nucleoporins (Goldberget al. 1997; Gantet al. ...
The Nucleosome Remodeling Factor ISWI Functionally Interacts With an Evolutionarily Conserved Network of Cellular Factors |...
... that would in principle allow the selective binding of methylated cytosine/guanine DNA, potentially linking ISWI activity with ...
CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering | Genetics
If these guanine residues are not present in the chosen guide sequence, they can either be substituted for the most 5′ residues ...
Participation of DNA Polymerase ζ in Replication of Undamaged DNA in Saccharomyces cerevisiae | Genetics
1999 MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae. Mol. Cell 4: ...
Insulator and Ovo Proteins Determine the Frequency and Specificity of Insertion of the gypsy Retrotransposon in Drosophila...
Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming ...
Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in Caenorhabditis...
Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming ...
Accidental Amplification and Inactivation of a Methyltransferase Gene Eliminates Cytosine Methylation in Mycosphaerella...
Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming ...
Trans-Kingdom Transposition of the Maize Dissociation Element | Genetics
Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming ...
High-Resolution Sex-Specific Linkage Maps of the Mouse Reveal Polarized Distribution of Crossovers in Male Germline | Genetics
Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming ...
Isochore Evolution in Mammals: A Human-Like Ancestral Structure | Genetics
VERTEBRATE nuclear genomes are characterized by a peculiar structure regarding the spatial distribution of guanine and cytosine ...