Genome-wide association study identifies three novel loci for type 2 diabetes
To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide ... Polymorphism, Single Nucleotide Substances * GPSM1 protein, human * Guanine Nucleotide Dissociation Inhibitors * Leptin ... To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide ...
Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance - PubMed
Previous genome-wide association studies have highlighted single-nucleotide polymorphisms (SNPs; rs204989 and rs204991) in a ... Guanine Nucleotide Dissociation Inhibitors / antagonists & inhibitors Actions. * Search in PubMed * Search in MeSH ... Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with Opioid Use Disorder in West ... Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic ...
Implementation of pharmacogenetic testing in medication reviews in a hospital setting - PubMed
Guanine Nucleotide Dissociation Inhibitors Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits - PubMed
Guanine Nucleotide Dissociation Inhibitors / genetics Actions. * Search in PubMed * Search in MeSH ...
Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation - PubMed
Guanine Nucleotide Dissociation Inhibitors / genetics Actions. * Search in PubMed * Search in MeSH ...
Ang II Promotes SUMO2/3 Modification of RhoGDI1 Through Aos1 and Uba2 Subunits, and then Regulates RhoGDI1 Stability and Cell...
rho Guanine Nucleotide Dissociation Inhibitor alpha / metabolism* Actions. * Search in PubMed * Search in MeSH ...
Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression - PubMed
rho Guanine Nucleotide Dissociation Inhibitor alpha / genetics* Actions. * Search in PubMed * Search in MeSH ...
Unconventional myosin VIIA promotes melanoma progression - PubMed
rho Guanine Nucleotide Dissociation Inhibitor beta / genetics* Actions. * Search in PubMed * Search in MeSH ...
Comprehensive analysis of miRNA-mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and...
rho Guanine Nucleotide Dissociation Inhibitor beta / genetics Actions. * Search in PubMed * Search in MeSH ...
KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1 - PubMed
rho Guanine Nucleotide Dissociation Inhibitor beta / metabolism* Actions. * Search in PubMed * Search in MeSH ... EZH2, which catalyses the methylation of H3K27, functions to silence ARHGDIB expression, and an EZH2 inhibitor can neutralize ...
Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function - PubMed
Guanine Nucleotide Dissociation Inhibitors* / genetics Actions. * Search in PubMed * Search in MeSH ... A total of 128 single-nucleotide polymorphisms (SNPs) within GPSM1 were analysed in 21,897 T2DM cases and 32,710 healthy ...
Cannabinoid receptor interacting protein 1a interacts with myristoylated Gαi N terminus via a unique gapped β-barrel structure ...
... sandwich fatty acid-binding proteins that carry endocannabinoid compounds and the Rho-guanine nucleotide dissociation inhibitor ... guanine nucleotide dissociation inhibitor; PDE6δ, phosphodiesterase 6 delta subunit. ... Keywords: G protein-coupled receptors; endocannabinoid system; fatty acid-binding protein; guanine nucleotide dissociation ...
Compromised Protein Prenylation as Pathogenic Mechanism in Mevalonate Kinase Deficiency - PubMed
Guanine nucleotide dissociation inhibitor (GDI), guanine nucleotide exchange factor (GEF), GTPase activating protein (GAP). ...
Pleiotropic effects of statins - PubMed
... reductase inhibitors not only prevents the synthesis of cholesterol biosynthesis but also inhibits the synthesis of essential ... including guanine nucleotide exchange factors, GTPase-activating proteins, and guanine nucleotide dissociation inhibitors. An ... Statins or 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors not only prevents the synthesis of cholesterol ... Plasminogen activator inhibitor-1; t-PA: Tissue-type plasminogen activator ...
Mutations in GDI1 and X-linked non-specific mental retardation - PubMed
Guanine Nucleotide Dissociation Inhibitors / genetics* Actions. * Search in PubMed * Search in MeSH ... Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental ... We have found 3 nucleotide (nt) substitutions: an intronic polymorphism at nt 107877 A --, C, a polymorphism in exon 3 at nt ...
Direct multiplex imaging and optogenetics of Rho GTPases enabled by near-infrared FRET - PubMed
... thus maintaining the native interaction with appropriate membrane domains and the guanine nucleotide dissociation inhibitor ( ... coefficient as a function of timelags between RhoA and Rac1 activities in protruding edge of MEFs with ROCK inhibitor Y-27632 ...
The GAP activity of type III effector YopE triggers killing of Yersinia in macrophages - PubMed
Regulation of Rac1 activation by host guanine nucleotide dissociation inhibitor (GDI) or guanine nucleotide exchange factor ( ... Using a Rac inhibitor NSC23766 and a Rho inhibitor TAT-C3, we show that macrophages restrict Yersinia intracellular survival in ... Figure 8. Survival of different Y. pseudotuberculosis strains inside macrophages, in the presence or absence of Rac inhibitor ...
The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth...
TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite ... and that this is because of an association of PLPPR1with the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI1). ... Bokoch GM, Bohl BP and Chuang TH (1994) Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding ...
RhoA Signaling in Neurodegenerative Diseases - PubMed
... guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), guanine nucleotide dissociation inhibitors (GDIs ... Marked in blue is the P-loop (G1 motif) that binds the β,γ-phosphate of the guanine nucleotide and a Mg2+ ion. Marked in red ... The G-domain responsible for nucleotide binding contains five motifs, G1-G5, where the G2 and G3 motifs are located in the ...
G-protein signaling: back to the future - PubMed
... α to receptor and also acts as a guanine nucleotide dissociation inhibitor (GDI) for Gα·GDP, slowing the spontaneous exchange ... B) Close-up view of the guanine nucleotide binding pocket of a chimeric Gαt/i1 subunit (structural coordinates from PBD ID: ... Ligand-bound GPCRs act as guanine nucleotide exchange factors (GEFs) by inducing a conformational change in the Gα subunit, ... An N-terminal CDC25 (cell division cycle protein 25-like) domain has been shown to promote guanine nucleotide exchange of Ras- ...
Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits - PubMed
Guanine Nucleotide Dissociation Inhibitors / genetics Actions. * Search in PubMed * Search in MeSH ...
A C-term truncated EIF2Bγ protein encoded by an intronically polyadenylated isoform introduces unfavorable EIF2Bγ-EIF2γ...
The GDP to GTP exchange within EIF2 is facilitated by the guanine nucleotide exchange factor EIF2B (α-ε subunits). During ... The GDP to GTP exchange within EIF2 is facilitated by the guanine nucleotide exchange factor EIF2B (α-ε subunits). During ... Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes. Elife. 2017;6:e24542. ... stress-induced conditions, phosphorylation of the α-subunit of EIF2 turns EIF2 into an inhibitor of EIF2B. In turn, inhibition ...
Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium - PubMed
The coupling of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) with G proteins is ... The coupling of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) with G proteins is ... Ras inhibitor CAPRI enables neutrophil-like cells to chemotax through a higher-concentration range of gradients. Xu X, Wen X, ... The cAMP-induced G protein subunits dissociation monitored in live Dictyostelium cells by BRET reveals two activation rates, a ...
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases - PubMed
Geranyl-geranyl-modified Rab GTPases in their GDP-bound state are tightly bound by guanine dissociation inhibitors (GDIs) in ... Figure 5-figure supplement 2.. Rab8a guanine nucleotide exchange assays. (A) Ribbon structure of Rab8a in complex with Rabin8 ( ... The dissociation constants (Kd) ± SD are indicated. Error bars are mean ± SD (n=3). SD, standard deviation; wt, wild type. DOI: ... C) Fold changes (T72A/T72E, n=4) of regulated proteins shown in (B). (D) Kinetic measurements of the dissociation of mant-GDP ...
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene -...
Objective: In a genome-wide association scan, the rs738409 C,G single nucleotide polymorphism (SNP) in the patatin-like ... Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Concurrent Type 2 Diabetes Mellitus and Non-Alcoholic ... Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene ... Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene ...
A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer -...
PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize ... in the presence of the following eIF2α kinase inhibitors for 96 h: A-92 (GCN2 inhibitor), C16 (PKR inhibitor), GSK2606414 (PERK ... Fail-safe control of translation initiation by dissociation of eIF2alpha phosphorylated ternary complexes. Elife. 2017;6 - PMC ... The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell lines. Lee J, Keam B, Kim S, Heo ...
The RASopathies: from pathogenetics to therapeutics - PubMed
Activation of MRAS, which can occur via guanine nucleotide exchange factor activity or via mutation, myristylation of SHOC2, or ... direct RAS inhibitors and RAS/MAPK pathway inhibitors, might be leveraged for patients with RASopathies. ... Bmax, maximum specific binding; Kd, dissociation constant. (B) Transfection of RASopathy variants into mammalian cells. These ... Finally, we review how the recently developed drugs targeting RAS/MAPK-driven malignancies, such as inhibitors of RAS ...
Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation - PubMed
RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... The resulting GDP-bound RAB18 is susceptible to GDP dissociation inhibitor (GDI)-mediated extraction into the cytosol. ...
Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation - PubMed
RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... The resulting GDP-bound RAB18 is susceptible to GDP dissociation inhibitor (GDI)-mediated extraction into the cytosol. ...
Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins - PubMed
... recognizes UV-induced photoproducts during global genome nucleotide excision repair (GG-NER). We recently demonstrated a ... Cells were pretreated with DMSO (CTR), NEDDylation inhibitor (NAE1i) or de-NEDDylation inhibitor (CSN5i) for 1.5 h. e ... OGG1 recruitment facilitates the dissociation of DDB2. In the absence of downstream repair, DDB2 is retained longer at 8-oxoG ... Guanine / analogs & derivatives* Actions. * Search in PubMed * Search in MeSH * Add to Search ...