To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide ... Polymorphism, Single Nucleotide Substances * GPSM1 protein, human * Guanine Nucleotide Dissociation Inhibitors * Leptin ... To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide ...
Previous genome-wide association studies have highlighted single-nucleotide polymorphisms (SNPs; rs204989 and rs204991) in a ... Guanine Nucleotide Dissociation Inhibitors / antagonists & inhibitors Actions. * Search in PubMed * Search in MeSH ... Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with Opioid Use Disorder in West ... Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic ...
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Guanine Nucleotide Dissociation Inhibitors / genetics Actions. * Search in PubMed * Search in MeSH ...
Guanine Nucleotide Dissociation Inhibitors / genetics Actions. * Search in PubMed * Search in MeSH ...
rho Guanine Nucleotide Dissociation Inhibitor alpha / metabolism* Actions. * Search in PubMed * Search in MeSH ...
rho Guanine Nucleotide Dissociation Inhibitor alpha / genetics* Actions. * Search in PubMed * Search in MeSH ...
rho Guanine Nucleotide Dissociation Inhibitor beta / genetics* Actions. * Search in PubMed * Search in MeSH ...
rho Guanine Nucleotide Dissociation Inhibitor beta / genetics Actions. * Search in PubMed * Search in MeSH ...
rho Guanine Nucleotide Dissociation Inhibitor beta / metabolism* Actions. * Search in PubMed * Search in MeSH ... EZH2, which catalyses the methylation of H3K27, functions to silence ARHGDIB expression, and an EZH2 inhibitor can neutralize ...
Guanine Nucleotide Dissociation Inhibitors* / genetics Actions. * Search in PubMed * Search in MeSH ... A total of 128 single-nucleotide polymorphisms (SNPs) within GPSM1 were analysed in 21,897 T2DM cases and 32,710 healthy ...
... sandwich fatty acid-binding proteins that carry endocannabinoid compounds and the Rho-guanine nucleotide dissociation inhibitor ... guanine nucleotide dissociation inhibitor; PDE6δ, phosphodiesterase 6 delta subunit. ... Keywords: G protein-coupled receptors; endocannabinoid system; fatty acid-binding protein; guanine nucleotide dissociation ...
Guanine nucleotide dissociation inhibitor (GDI), guanine nucleotide exchange factor (GEF), GTPase activating protein (GAP). ...
... reductase inhibitors not only prevents the synthesis of cholesterol biosynthesis but also inhibits the synthesis of essential ... including guanine nucleotide exchange factors, GTPase-activating proteins, and guanine nucleotide dissociation inhibitors. An ... Statins or 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors not only prevents the synthesis of cholesterol ... Plasminogen activator inhibitor-1; t-PA: Tissue-type plasminogen activator ...
Guanine Nucleotide Dissociation Inhibitors / genetics* Actions. * Search in PubMed * Search in MeSH ... Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental ... We have found 3 nucleotide (nt) substitutions: an intronic polymorphism at nt 107877 A --, C, a polymorphism in exon 3 at nt ...
... thus maintaining the native interaction with appropriate membrane domains and the guanine nucleotide dissociation inhibitor ( ... coefficient as a function of timelags between RhoA and Rac1 activities in protruding edge of MEFs with ROCK inhibitor Y-27632 ...
Regulation of Rac1 activation by host guanine nucleotide dissociation inhibitor (GDI) or guanine nucleotide exchange factor ( ... Using a Rac inhibitor NSC23766 and a Rho inhibitor TAT-C3, we show that macrophages restrict Yersinia intracellular survival in ... Figure 8. Survival of different Y. pseudotuberculosis strains inside macrophages, in the presence or absence of Rac inhibitor ...
TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite ... and that this is because of an association of PLPPR1with the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI1). ... Bokoch GM, Bohl BP and Chuang TH (1994) Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding ...
... guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), guanine nucleotide dissociation inhibitors (GDIs ... Marked in blue is the P-loop (G1 motif) that binds the β,γ-phosphate of the guanine nucleotide and a Mg2+ ion. Marked in red ... The G-domain responsible for nucleotide binding contains five motifs, G1-G5, where the G2 and G3 motifs are located in the ...
... α to receptor and also acts as a guanine nucleotide dissociation inhibitor (GDI) for Gα·GDP, slowing the spontaneous exchange ... B) Close-up view of the guanine nucleotide binding pocket of a chimeric Gαt/i1 subunit (structural coordinates from PBD ID: ... Ligand-bound GPCRs act as guanine nucleotide exchange factors (GEFs) by inducing a conformational change in the Gα subunit, ... An N-terminal CDC25 (cell division cycle protein 25-like) domain has been shown to promote guanine nucleotide exchange of Ras- ...
Guanine Nucleotide Dissociation Inhibitors / genetics Actions. * Search in PubMed * Search in MeSH ...
The GDP to GTP exchange within EIF2 is facilitated by the guanine nucleotide exchange factor EIF2B (α-ε subunits). During ... The GDP to GTP exchange within EIF2 is facilitated by the guanine nucleotide exchange factor EIF2B (α-ε subunits). During ... Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes. Elife. 2017;6:e24542. ... stress-induced conditions, phosphorylation of the α-subunit of EIF2 turns EIF2 into an inhibitor of EIF2B. In turn, inhibition ...
The coupling of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) with G proteins is ... The coupling of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) with G proteins is ... Ras inhibitor CAPRI enables neutrophil-like cells to chemotax through a higher-concentration range of gradients. Xu X, Wen X, ... The cAMP-induced G protein subunits dissociation monitored in live Dictyostelium cells by BRET reveals two activation rates, a ...
Geranyl-geranyl-modified Rab GTPases in their GDP-bound state are tightly bound by guanine dissociation inhibitors (GDIs) in ... Figure 5-figure supplement 2.. Rab8a guanine nucleotide exchange assays. (A) Ribbon structure of Rab8a in complex with Rabin8 ( ... The dissociation constants (Kd) ± SD are indicated. Error bars are mean ± SD (n=3). SD, standard deviation; wt, wild type. DOI: ... C) Fold changes (T72A/T72E, n=4) of regulated proteins shown in (B). (D) Kinetic measurements of the dissociation of mant-GDP ...
Objective: In a genome-wide association scan, the rs738409 C,G single nucleotide polymorphism (SNP) in the patatin-like ... Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Concurrent Type 2 Diabetes Mellitus and Non-Alcoholic ... Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene ... Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene ...
PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize ... in the presence of the following eIF2α kinase inhibitors for 96 h: A-92 (GCN2 inhibitor), C16 (PKR inhibitor), GSK2606414 (PERK ... Fail-safe control of translation initiation by dissociation of eIF2alpha phosphorylated ternary complexes. Elife. 2017;6 - PMC ... The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell lines. Lee J, Keam B, Kim S, Heo ...
Activation of MRAS, which can occur via guanine nucleotide exchange factor activity or via mutation, myristylation of SHOC2, or ... direct RAS inhibitors and RAS/MAPK pathway inhibitors, might be leveraged for patients with RASopathies. ... Bmax, maximum specific binding; Kd, dissociation constant. (B) Transfection of RASopathy variants into mammalian cells. These ... Finally, we review how the recently developed drugs targeting RAS/MAPK-driven malignancies, such as inhibitors of RAS ...
RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... The resulting GDP-bound RAB18 is susceptible to GDP dissociation inhibitor (GDI)-mediated extraction into the cytosol. ...
RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... RAB3GAP1 and RAB3GAP2 form a binary RAB3GAP complex that functions as a guanine-nucleotide exchange factor (GEF) for RAB18, ... The resulting GDP-bound RAB18 is susceptible to GDP dissociation inhibitor (GDI)-mediated extraction into the cytosol. ...
... recognizes UV-induced photoproducts during global genome nucleotide excision repair (GG-NER). We recently demonstrated a ... Cells were pretreated with DMSO (CTR), NEDDylation inhibitor (NAE1i) or de-NEDDylation inhibitor (CSN5i) for 1.5 h. e ... OGG1 recruitment facilitates the dissociation of DDB2. In the absence of downstream repair, DDB2 is retained longer at 8-oxoG ... Guanine / analogs & derivatives* Actions. * Search in PubMed * Search in MeSH * Add to Search ...