Cells | Free Full-Text | Preconditioning or Postconditioning with 8-Br-cAMP-AM Protects the Heart against Regional Ischemia and...
cAMP activates two major signal transduction pathways in the heart, PKA [14] and a guanine nucleotide exchange protein directly ... ISA supplemented with complete protease inhibitors cocktail (Roche) and phosphatases inhibitors cocktail 1 (Sigma)) and ... has demonstrated that in vitro dissociation of HKII alone does not fully replicate the effects of global ischaemia on ... Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998, 396, 474-477. [Google Scholar ...
IJMS | Free Full-Text | Platinum Salts in Patients with Breast Cancer: A Focus on Predictive Factors
Upon MX, APE1 inhibitor, cells are resistant to CDDP treatment. A: non-pegylated liposomal doxorubicin; AC: doxorubicin + ... Slyskova, J.; Sabatella, M.; Ribeiro-Silva, C.; Stok, C.; Theil, A.F.; Vermeulen, W.; Lans, H. Base and nucleotide excision ... Reactive oxygen species-induced DNA damages, including the oxidation of the guanine (8oxoG), are efficiently repaired by the ... Np63 dissociation from TAp73 in vitro [86]. Free TAp73 can, therefore, trigger the pro-apoptotic cascade. In light of this ...