9), and the dissociation was inhibited in the presence of a CaMKII inhibitor (Fig. 9). These results suggest that the calpain- ... 2004) GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. J Biol ... C, Dissociation constants (means ± SE) for each Homer3 protein that was phosphorylated by CaMKII for the indicated time period ... In regard to the dissociation from mGluR1α, Xu et al. (2007) showed that mGluR1α is cleaved by calpain upstream of its Homer- ...

Perrot V, Vazquez-Prado J, Gutkind JS (2002) Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia- ... or GDP dissociation inhibitors in neurons. In the present study, we found that inhibition of either CaMKII or PKC can abolish ... Furthermore, we found that treatment of the culture with Y27632 (10 μm), a specific inhibitor of Rho kinase, had no effect on ... To further test the role of these enzymes in growth cone turning, we applied an extracellular gradient of enzyme inhibitors, ...