Melanocyte Protein PMEL (ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma...
ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ... ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ... ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ... ME20M or Melanocyte Protein Pmel 17 or Melanocytes Lineage Specific Antigen GP100 or Melanoma Associated ME20 Antigen or P1 or ...https://www.marketresearch.com/Global-Markets-Direct-v3480/Melanocyte-Protein-PMEL-ME20M-Pmel-11679178/
Targeted Immunotherapy Using Reconstituted Chaperone Complexes of Heat Shock Protein 110 and Melanoma-associated Antigen gp100 ...
Melanoma-associated antigen gp100 is highly expressed in about 80% of HLA-A2-positive malignant melanomas (23 , 24) . It can be ... human melanoma-associated antigen gp100) during heat shock. We demonstrate that hsp110 can form chaperone complexes with gp100 ... a study in which we use a tumor protein antigen as substrate, specifically melanoma-associated antigen gp100, was undertaken to ... hsp110 and gp100 mixture without heat shock; hsp110 plus previously heat-denatured gp100; CFA plus gp100; or the hsp110-gp100 ...http://cancerres.aacrjournals.org/content/63/10/2553
B and C, modulation of cross-presentation of the melanoma gp100 antigen in vivo. Cells from the human melanoma cell line FEMX ... Using melanoma cells, we also found that fractions enriched for autophagosomes mediated the cross-presentation of gp100 antigen ... Knockdown of Beclin-1 in antigen donor cells decreased cross-presentation of tumor antigens by DC. A, B16 F10 melanoma cells ... Using both HEK 293T cells that expressed the model antigen OVA and melanoma cells as antigen donors, we show that ...http://cancerres.aacrjournals.org/content/68/17/6889
Vaccines | Free Full-Text | Chemokines as Cancer Vaccine Adjuvants | HTML
... in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing recruitment of antigen ... immunized mice with DCs co-transfected with XCL1 and melanoma antigen gp100 (XCL1/gp100-DC) using an adenoviral vector. Their ... He, S.; Wang, L.; Wu, Y.; Li, D.; Zhang, Y. CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 induce ... CCL5pDNA + gp100 pDNA vaccine, with CCL5 + hgp100 viral vector boost. Melanoma. Murine. . ...http://www.mdpi.com/2076-393X/1/4/444/htm
therapeutic vaccines for colorectal cancer | Springer for Research & Development
Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens. J Natl ... Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides. ... Augmentation of T-cell response with a melanoma cell vaccine expressing specific HLA-A antigens. Ann N Y Acad Sci 1993; 690: ... Polyvalent melanoma vaccine improves survival of patients with metastatic melanoma. Ann N Y Acad Sci 1993; 690: 120-34PubMed ...https://rd.springer.com/article/10.2165/00024669-200403050-00004
Less Yin, More Yang: Confronting the Barriers to Cancer Immunotherapy | Clinical Cancer Research
Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in situ ... Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in ... Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in ... Two of these antigens, MART-1 and gp100, seem to be expressed in the majority of fresh and cultured melanomas (12). Because ...http://clincancerres.aacrjournals.org/content/13/18/5250.full
Frontiers | Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings |...
Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding ... A peptide that must move to optimize fit with a TCR, such as the Tax11-19 antigen presented by HLA-A2 in Figure 1A, will result ... Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. ... Nakagawa M, Chiba-Kamoshida K, Udaka K, Nakanishi H. NMR study on the interaction between MHC class I protein and its antigen ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00935/full
Distribution of TRP1 in the Golgi and associated vesicl | Open-i
We have positioned these organelles relative to endosomes and lysosomes in pigmented melanoma cells and melanocytes. Melanosome ... We have positioned these organelles relative to endosomes and lysosomes in pigmented melanoma cells and melanocytes. Melanosome ... and other pigmented melanoma cells and melanocytes (not shown) demonstrated that TRP1 and Pmel17 localized to vesicular ... and other pigmented melanoma cells and melanocytes (not shown) demonstrated that TRP1 and Pmel17 localized to vesicular ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195785_JCB0010069.f3&req=4
CiNii 論文 - Cytokines Required for Induction of Histocompatibility Leukocyte Antigen-class I...
Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in ... Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24 restricted tumor-infiltrating lymphocytes ... A mutated β-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes ROBBINS P. F. ... Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL ...http://ci.nii.ac.jp/naid/10008092645
Kinetics of TCR Use in Response to Repeated Epitope-Specific Immunization | The Journal of Immunology
Improved induction of melanoma reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201 binding ... Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in ... 11). Patients with metastatic melanoma who received vaccination with the gp100 epitope gp100:209-217(210M) (abbreviated here as ... in melanoma patients exposed to the modified gp100 epitope gp100:209-217 (g209-2M) we observed in most patients that the Tc-pf ...http://www.jimmunol.org/content/166/9/5817?ijkey=2968399c3e079c1915da8369c9afc68744af9c89&keytype2=tf_ipsecsha
Recent questions and answers in Receptors, Biogenic Amine - lookformedical.com
gp100 Melanoma Antigen (0) * Heterotrimeric GTP-Binding Proteins (0) * LDL-Receptor Related Protein-Associated Protein (0) ...https://lookformedical.com/answers/en/chemicals-and-drugs/amino-acids-peptides-and-proteins/proteins/membrane-proteins/receptors-cell-surface/receptors-biogenic-amine
No questions in Receptors, Urokinase Plasminogen Activator - lookformedical.com
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gp100 Melanoma Antigen (0) * Heterotrimeric GTP-Binding Proteins (0) * LDL-Receptor Related Protein-Associated Protein (0) ...https://lookformedical.com/answers/en/chemicals-and-drugs/amino-acids-peptides-and-proteins/proteins/membrane-proteins/receptors-cell-surface/receptors-biogenic-amine/receptors-serotonin/receptors-serotonin-5-ht3
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GP-100 - Wikipedia
Ruger GP100, an American revolver glycoprotein 100, a melanoma antigen Gp100:209-217(210M), a peptide cancer vaccine.. ... GP-100 can refer to A model of Suzuki motorcycle The Japanese vintage motorcycle Suzuki GP 100 U is not described fully. A ...https://en.wikipedia.org/wiki/GP-100
Therapeutic Effectiveness of Recombinant Cancer Vaccines Is Associated with a Prevalent T-Cell Receptor α Usage by Melanoma...
Mendiratta KS, Thai G, Elashi NK, et al Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp100 and ... 1C) ⇓ . No reactivity against either gp100 or p15E was detected in mice that rejected the melanoma after immunization with rAd- ... Although studies with melanoma patients failed to reveal a correlation between AV 2.1 usage and avidity of antigen recognition ... This suggests that tumor growth in the host did not generate per se an immune reactivity to different melanoma antigens ...http://cancerres.aacrjournals.org/content/64/21/8068
Synergism of Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor...
1994) Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J. Exp. Med. ... extensive studies of melanoma patients revealed that CTLs against a number of melanocyte/melanoma-specific antigens (e.g., ... Our data demonstrate that the CTL response against melanoma antigens is an important component of the therapeutic antitumor ... 1999) Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte ...http://jem.rupress.org/content/194/6/823
Survivin as a Cancer Vaccine Target | OMICS International
1996) Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding ... Tyrosinase and gp100 are proteins that can serve as antigens that are recognized by CTL in melanoma patients [59-61]. Peptide ... 1994) A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J ... 2007) Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer ...https://www.omicsonline.org/open-access/survivin-as-a-cancer-vaccine-target-2157-7560.1000230.php?aid=26593
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma - Full Text View - ClinicalTrials...
Melanoma (Skin) Biological: MART-1 antigen Biological: aldesleukin Biological: gp100 antigen Phase 1 Phase 2 ... cells presenting the MART-1 and gp100 melanoma antigens with or without interleukin-2 in patients with metastatic melanoma. ... Melanoma of Immunization With Dendritic Cells Presenting Epitopes Derived From The Melanoma Associated Antigens MART-1 and gp 100 ... OUTLINE: This is a dose-escalation study of dendritic cells pulsed with MART-1 and gp100 antigens. ...https://clinicaltrials.gov/ct2/show/NCT00019214
Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells -...
Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with ... High levels of Met-72 antigen expression: correlation with metastatic activity of B16 melanoma tumor cell variants. J Natl ... Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection ... Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998;392: 86-9.. *CrossRef, ...http://onlinelibrary.wiley.com/doi/10.1002/ijc.1365/references
Glycoprotein 100 - Wikipedia
The gp100 protein is a melanoma antigen i.e. a tumor-associated antigen. Short fragments of it have been used to develop the ... gp100 cancer vaccine which is or contains gp100:209-217(210M). Hydrophilic recombinant gp100 protein (HR-gp100) has been ... In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ... "Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response". Cell ...https://en.wikipedia.org/wiki/Glycoprotein_100
T Cells Associated with Tumor Regression Recognize Frameshifted Products of the CDKN2A Tumor Suppressor Gene Locus and a...
Immunobiology of human melanoma antigens MART-1 and gp100 and their use for immuno-gene therapy. Int. Rev. Immunol. 14:173. ... Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory ... A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading ... A mutated β-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J. Exp. Med. 183: ...http://www.jimmunol.org/content/172/10/6057?ijkey=765b781272cb66551f15fa2a24ead94eec6e03ea&keytype2=tf_ipsecsha
Genus Avipoxvirus | Springer for Research & Development
... the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma. Clin ... The seminal observation of their utility for delivery of vaccine antigens to non-avian species has driven much of the interest ... Nazerian K, Yanagida N (1995) A recombinant fowlpox virus expressing the envelope antigen of subgroup A avian leukosis/sarcoma ... Hodge JW, Grosenbach DW, Schlom J (2002) Vector-based delivery of tumorassociated antigens and T-cell co-stimulatory molecules ...https://rd.springer.com/chapter/10.1007/978-3-7643-7557-7_11
Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens. J. Natl ... the melanoma differentiation antigen GM2 and BCG was shown to reduce the risk of relapse in patients with stage III melanoma ... 4 The abbreviations used are: IL, interleukin; NK, natural killer; Ag, antigen; Ab, antibody; TAA, tumor-associated antigen; ... Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med., 5: 677-685, ...http://clincancerres.aacrjournals.org/content/9/9/3222
Intratumoral electroporation of IL-12 cDNA eradicates established melanomas by Trp2180-188-specific CD8+ CTLs in a perforin...
... can lead to the eradication of established B16 melanoma tumors in mice. Here, we explore the immunological mechanism of the ... Robbins PF, Sette A, Appella E, Rosenberg SA (1995) Recognition of multiple epitopes in the human melanoma antigen gp100 by ... Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med 185(3):453-459 ... Corr M, von Damm A, Lee DJ, Tighe H (1999) In vivo priming by DNA injection occurs predominantly by antigen transfer. J Immunol ...https://link.springer.com/article/10.1007/s00262-012-1214-8