Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell | Diabetologia
Conditional knockout of the unfolded protein response (UPR) mediator Ire1α (also known as Ern1) in young beta cells of NOD mice ... Cai EP, Ishikawa Y, Zhang W et al (2020) Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell ... Similarly, mutation of the type 1 diabetes genome-wide association study gene Rnls, which controls UPR signalling, led to ... PS was supported by CIHR (FDN-353029, PJT-479040, PJT-479038, FRN-168480 [with JDRF], DT4-179512), Genome Canada (GAPP program ...
Genomics and clinical correlates of renal cell carcinoma | World Journal of Urology
Cancer Genome Atlas Research N, Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, ... The Von Hippel-Lindau (VHL) tumour suppressor gene undergoes bi-allelic knockout in the vast majority of clear cell RCCs. The ... The Von Hippel-Lindau (VHL) tumour suppressor gene, located at 3p25, undergoes bi-allelic knockout in the majority of ccRCCs [ ... Structural variants promote oncogenesis by altering the number of copies of genes in the genome or re-arranging the order of ...
Histological evaluation of sex differentiation and early sex identification in hatchery-produced greater amberjack (Seriola...
Sarropoulou E et al (2017) Full genome survey and dynamics of gene expression in the greater amberjack Seriola dumerili. ... Shu T, Zhai G, Pradhan A, Olsson PE, Yin Z (2020) Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is ...
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism |...
The importance of HO-1 has been underlined by the studies on HO-1 knockout animals. Poss and Tonegawa [72, 73] as well as Yet ... However, human genome epidemiology (HuGE) meta-analysis of HO-1 polymorphism and susceptibility to coronary artery disease (CAD ... Not only pro-tumoral effects of HO-1 are described; due to its antioxidant and genome protecting activities, HO-1 may exert the ... Ceriani MF, Hogenesch JB, Yanovsky M, Panda S, Straume M, Kay SA (2002) Genome-wide expression analysis in Drosophila reveals ...
The PRDM9 KRAB domain is required for meiosis and involved in protein interactions | Chromosoma
... is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. This role ... Prdm9 knockout (Prdm9 −/−) (Hayashi et al. 2005), CBA/JRj (Janvier Labs), and RJ2 (Grey et al. 2011) and B6 mice were used as ... Grey C, Baudat F, de Massy B (2009) Genome-wide control of the distribution of meiotic recombination. PLoS Biol 7:e35 ... c In Prdm9 knockout mice, CXXC1 could be associated with promoters/CpG islands similarly to the localization reported in ...
Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer's disease | SpringerLink
Rosenberger TA, Villacreses NE, Contreras MA, Bonventre JV, Rapoport SI (2003) Brain lipid metabolism in the cPLA2 knockout ... Genome Biol 3:1-12. Article Google Scholar *. Forlenza OV, Schaeffer EL, Gattaz WF (2002) Phospholipase A2 activity in rat ...
Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors | SpringerLink
2008). Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic ... 2003). Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target ...
A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice | Mammalian Genome
A Total of 5457 knockout lines with ECG data classified by IMPC centers worldwide; data is presented in numbers of knockout ... Oprea TI (2019) Exploring the dark genome: implications for precision medicine. Mamm Genome 30:192-200 ... Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell 154:452-464 ... Hotaling S, Kelley JL, Frandsen PB (2021) Toward a genome sequence for every animal: where are we now? Proc Natl Acad Sci USA. ...
De novo missense variants disrupting protein-protein interactions affect risk for autism through gene co-expression and protein...
Werling D, Pochareddy S, Choi J, An JY, Sheppard B, Peng M, Li Z, Dastmalchi C, Santperebaro G, Sousa A. Whole-genome and RNA ... and in vivo experiments have further shown that knockout mice with DDX5 and PABPC1 disassociated from polyribosomes displayed ... PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. Nucleic Acids Res. 2019; ... It employs a computationally efficient EM algorithm to deconvolve all genes in the genome. ...
Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development | Cellular and Molecular Life Sciences
TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. ... Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada ... Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A (1999) Smad5 knockout mice die at mid-gestation due to ... Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121(6):1845-1854 ...
ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits | Journal of Molecular Medicine
Alms1 knockout rats developed hypertension (a feature observed in 30% of AS patients [4]), suggested to be due at least in part ... Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new ... it is notable that a genome-wide RNAi screen identified ALMS1 as one of ~ 800 genes required for resistance to ionising ... of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome- ...
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity | Acta...
Conditional knockout of ClpP in heart tissue in DARS2-deficient mice attenuates mitochondrial cardiomyopathy [75]. In our study ... mitochondrial genome stability, and metabolism [30, 67]. Two mitochondrial proteases that regulate proteostasis in the matrix ... ClpP knockout mice exhibit growth retardation, mtDNA accumulation, inflammatory response and infertility, recapitulating the ...
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues | Diabetologia
Moreover, knockout mice for Mmp3/11/19, fed a high-fat diet (HFD) display marked hypertrophy of AT [67, 68]. Given that several ... Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. Stefania Carobbio & Antonio Vidal-Puig ...