Poly-L-lysine Prevents Senescence and Augments Growth in Culturing Mesenchymal Stem Cells Ex Vivo
Genome-wide expression profiles of MSCs were analysed by human genome microarray. We analysed the expression patterns of ... Human Genome Microarray. The synthesis of target cRNA probes and hybridization were performed using Agilents Low RNA Input ... To the best of our knowledge, this study is the first to compare genome-wide expression profiles of MSCs cultured on PLL-coated ... using human genome microarray to gain insight into the molecular characteristics of senescence. Functional classification of ...
Evaluation of Allele Frequency Estimation Using Pooled Sequencing Data Simulation
... technology has provided researchers with opportunities to study the genome in unprecedented detail. In particular, NGS is ... F. A. Wright, L. J. Strug, V. K. Doshi et al., "Genome-wide association and linkage identify modifier loci of lung disease ... R. M. Durbin, D. L. Altshuler, G. R. Abecasis et al., "A map of human genome variation from population-scale sequencing," ... M. I. McCarthy and J. N. Hirschhorn, "Genome-wide association studies: potential next steps on a genetic journey," Human ...
m6A RNA Methylation Regulators Elicit Malignant Progression and Predict Clinical Outcome in Hepatocellular Carcinoma
We obtained the expression profiles of m,sup,6,/sup,A-related genes for HCC patients from the International Cancer Genome ... Consortium and The Cancer Genome Atlas datasets. Most of the m,sup,6,/sup,A RNA methylation regulators were confirmed to be ... Kyoto Encyclopedia of Genes and Genomes.. Data Availability. All data generated or analyzed during this study are included in ... We obtained the expression profiles of m6A-related genes for HCC patients from the International Cancer Genome Consortium and ...
Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma
Genome-wide association analysis revealed that the NRP1 expression was strongly associated with kidney renal clear cell ... Genome-wide association of NRP1 and NRP2 mRNA in pancancer (Regulome program). NRP1 is broadly associated with genome-wide ... Genome-Wide Association of NRP1 and NRP2 mRNA in Various Cancers. The previous results revealed that NRP1 might play important ... Pan-cancer alterations of the MYC oncogene and its proximal network across The Cancer Genome Atlas," Cell Systems, vol. 6, no. ...
Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with...
The Cancer Genome Atlas Research Network, J. N. Weinstein, E. A. Collisson et al., "The Cancer Genome Atlas Pan-Cancer analysis ... The Cancer Genome Atlas Network, "Comprehensive molecular characterization of human colon and rectal cancer," Nature, vol. 487 ... C. Greenman, P. Stephens, R. Smith et al., "Patterns of somatic mutation in human cancer genomes," Nature, vol. 446, no. 7132, ... This phenomenon might be biased by the data source from big cancer project like The Cancer Genome Atlas (TCGA), Pan-Cancer ...
Regulation of T Helper 17 by Bacteria: An Approach for the Treatment of Hepatocellular Carcinoma
In accordance to the highly reduced genome, SFBs lack a number of enzymes for basic metabolic pathways that are important for ... J. F. Kim, H. Jeong, D. S. Yu et al., "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011 ... T. Prakash, K. Oshima, H. Morita et al., "Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent ... M. A. Schell, M. Karmirantzou, B. Snel et al., "The genome sequence of Bifidobacterium longum reflects its adaptation to the ...
Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation
A. Dehghan, J. Dupuis, M. Barbalic et al., "Meta-analysis of genome-wide association studies in ,. 80. 000 subjects identifies ...
Sequence Variation and Expression of the Gimap Gene Family in the BB Rat
S. Bieg, G. Koike, J. Jiang et al., "Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat," Mammalian Genome ... We suspect that this region of the rat genome does not code for a protein, which is similar to the human GIMAP3 pseudogene [3] ... Gimap3 is not annotated in the rat genome sequence. Genomic sequencing of the putative ortholog of mouse Gimap3 from base pair ... Mouse Genome Database (MGD), Mouse Genome Informatics Web Site, The Jackson Laboratory, Bar Harbor, Maine, http://www. ...
MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma
C. Baer, R. Claus, and C. Plass, "Genome-wide epigenetic regulation of miRNAs in cancer," Cancer Research, vol. 73, pp. 473-477 ... E. Staub, J. Gröne, D. Mennerich et al., "A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer," ... The tumor suppressor protein Tp53, the guardian of the genome, is essential for the carcinogenesis prevention. In the current ... "Characterisation of hairy cell leukaemia by tiling resolution array-based comparative genome hybridisation: a series of 13 ...
Integration of Gene Expression Profile Data to Verify Hub Genes of Patients with Stanford A Aortic Dissection
The gene ontology and pathway enrichment of DEGs were performed by DAVID and Kyoto Encyclopedia of Genes and Genomes online ... The gene ontology and pathway enrichment of DEGs were performed by DAVID and Kyoto Encyclopedia of Genes and Genomes online ... Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the pathways. The gradual color represents the P value; the size ... Kyoto Encyclopedia of Genes and Genomes) pathway analysis. GO analysis included categories of cellular component (CC), ...
Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network...
Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein–protein interaction ... package cluster Profiler [19] was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) ... Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) ... These memory regions of the genome always become accessible while suffering stimuli and remain accessible after inflammation ...
N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis
Herein, genome-wide transcriptome profiling (RNA-Seq) was used to screen the differentially expressed genes (DEGs) in FO- ... Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed by setting all the GO ...
Deciphering the Molecular Targets and Mechanisms of HGWD in the Treatment of Rheumatoid Arthritis via Network Pharmacology and...
Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed in R software (Bioconductor, ... Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) are important methods that describe the features ... Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed in R software (Bioconductor, ...
Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast...
... gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival ... a) mRNA expression levels in the Cancer Genome Atlas (TCGA). (b) Protein expression levels in normal and tumor breast tissues ... and HSP90AB1 and the overall survival in the breast cancer samples from The Cancer Genome Atlas. (b) Correlation analysis ... in which the database utilized data from GEO or RNA-seq libraries from The Cancer Genome Atlas (TCGA), Therapeutically ...
DOK5 as a Prognostic Biomarker of Gastric Cancer Immunoinvasion: A Bioinformatics Analysis
We ran Kyoto Encyclopedia of Genes and Genomes (KEGG) as well as Gene Ontology (GO) functional enrichment assessment on DOK5. ... The Cancer Genome Atlas), as well as the Genotype-Tissue Expression project; thus, it implements a standard processing pipeline ... Kyoto Encyclopedia of Genes and Genomes. Verification of upregulation of DOK5 in GC by qRT-PCR. A combined enrichment plot has ...
SNHG5/miR-299-5p/ATF2 Axis as a Biomarker in Immune Microenvironment of Intervertebral Disc Degeneration
DEGs: differentially expressed genes; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; RF: random forest; ROC ... enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the hubmRNAs in ceRNA. The ...
The Signaling of Cellular Senescence in Diabetic Nephropathy
Recently, genome editing is attracting the notice of scientists [239, 240]. However, although with the prospective aspects, ... A. Diot, K. Morten, and J. Poulton, "Mitophagy plays a central role in mitochondrial ageing," Mammalian Genome, vol. 27, no. 7- ... H. Lans and J. H. Hoeijmakers, "Genome stability, progressive kidney failure and aging," Nature Genetics, vol. 44, no. 8, pp. ... C. Compagnucci and E. Bertini, "The potential of iPSCs for the treatment of premature aging disorders," Genome Biology, vol. 18 ...
A Taxonomy on Smart Healthcare Technologies: Security Framework, Case Study, and Future Directions
Genomics refers to the genome and DNA data of an organism. It requires a large amount of storage and good software that ... 114] presented a cross-platform immersive virtual reality system to enable graph genome interaction and analysis. Campbell [115 ... M. Kuznetsov, A. Elor, S. Kurniawan et al., "The immersive graph genome explorer: navigating genomics in immersive virtual ...
The Differential Gene Expression Pattern of Mycobacterium tuberculosis in Response to Capreomycin and PA-824 versus First-Line...
In terms of the distribution of identified genes in a specific category relative to the whole genome, only the categories of PE ... About 10% of the genes in M. tuberculosis genome are dedicated to the production of two families of glycine-rich proteins ... where g is the total number of genes in the genome.. 6. Results. 6.1. Genes Differentially Expressed in Capreomycin and PA-824 ... The chance probability of identifying 42 genes from all genes in the M. tuberculosis genome such that 6 genes are in the ...
Delineation of the Germline and Somatic Mutation Interaction Landscape in Triple-Negative and Non-Triple-Negative Breast Cancer
i,Methods,/i,. We addressed this problem by integrating germline mutation information from genome-wide association studies with ... The International Cancer Genome Consortium, "International network of cancer genome projects," Nature, vol. 464, no. 7291, pp. ... J. N. Weinstein, The Cancer Genome Atlas Research Network, E. A. Collisson et al., "The Cancer Genome Atlas Pan-Cancer analysis ... S. M. Waszak, G. Tiao, B. Zhu et al., "Germline determinants of the somatic mutation landscape in 2, 642 cancer genomes," PLoS ...
Mutagenesis as a Tool in Plant Genetics, Functional Genomics, and Breeding
Both genetic (Targeting Induced Local Lesions in Genomes; TILLING) and phenotypic screens are evaluated. Finally, different ... X. Huang, Q. Feng, Q. Qian et al., "High-throughput genotyping by whole-genome resequencing," Genome Research, vol. 19, no. 6, ... availability of a reference genome theoretically allows for assembly and analysis of complete mutant genomes. This can be ... Using EST libraries instead of the fully sequenced genome, Feiz et al. linked wheat grain hardness to Puroindoline a and b ...
Integrated Network Pharmacology and Mice Model to Investigate Qing Zao Fang for Treating Sjögren's Syndrome
2.1.4. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Analysis. Following import of the 20 core targets ...
A Novel Gene Signature to Predict Survival Time and Incident Ventricular Arrhythmias in Patients with Dilated Cardiomyopathy
Kyoto Encyclopedia of Genes and Genomes, Reactive pathways, and Canonical Pathways [13]. All genes in the genome have been used ... and 6 Kyoto Encyclopedia of Genes and Genomes pathways. The risk gene PPP2R5A is mainly involved in Influenza Infection, ...
Cloning, Identification, and Characterization of the rpoS-Like Sigma Factor rpoX from Vibrio alginolyticus
... genome sequences revealed that in addition to rpoS, an rpoS-like sigma factor was found in V. alginolyticus 12G01. The protein ... family of sigma factors," Genome Biology, vol. 4, no. 1, p. 203, 2003. ...
Expression Pattern and Prognostic Value of EPHA/EFNA in Breast Cancer by Bioinformatics Analysis: Revealing Its Importance in...
The Cancer Genome Atlas Research Network, J. N. Weinstein, E. A. Collisson et al., "The Cancer Genome Atlas Pan-Cancer analysis ... A. Burleigh, S. McKinney, J. Brimhall et al., "A co-culture genome-wide RNAi screen with mammary epithelial cells reveals ... Sources for the database include GEO, EGA (European Genome-Phenome Archive), and TCGA. This platform, which contains gene ... and RNA sequences from The Cancer Genome Atlas (TCGA) [21]. In this study, we compared the transcriptional levels of EPHA/EFNA ...
Gene Identification and Characterization of Correlations for DEPs DEGs Same Trend Responding to Salinity Adaptation in Scylla...
A. Pandey and M. Mann, "Proteomics to study genes and genomes," Nature, vol. 405, no. 6788, pp. 837-846, 2000. ... This relation automatically yields a number of functional predictions for poorly characterized genomes. The COGs comprise a ... paramamosain genome has not yet been completed, and the combined analysis of histology and multiomics is a suitable approach ... a knowledge-based approach for interpreting genome-wide expression profiles," Proceedings of the National Academy of Sciences, ...
How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications
The Cancer Genome Atlas Network, "Comprehensive molecular characterization of human colon and rectal cancer," Nature, vol. 487 ... V. Emuss, M. Garnett, C. Mason, The Cancer Genome Project, and R. Marais, "Mutations of C-RAF are rare in human cancer because ... T. Hinoue, D. J. Weisenberger, C. P. E. Lange et al., "Genome-scale analysis of aberrant DNA methylation in colorectal cancer ... Recent studies that have utilised genome-wide methylation arrays have confirmed that those cancers with the most frequent and ...
Fecal Microbiota Transplants for Inflammatory Bowel Disease Treatment: Synthetic- and Engineered Communities-Based Microbiota...
J. G. Caporaso, C. L. Lauber, E. K. Costello et al., "Moving pictures of the human microbiome," Genome Biology, vol. 12, no. 5 ... S. Brugiroux, M. Beutler, C. Pfann et al., "Genome-guided design of a defined mouse microbiota that confers colonization ...
Mucosal Immunity in the Female Genital Tract, HIV/AIDS
There are few copies of the viral genome in the basal layer [304]; the production of infective particles occurs only in the ... "Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification ...
Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice
The highest Ad vector genome copy numbers and transgene expression were found in the neonatal liver. The neonatal heart ... Ad genome copy numbers in each organ were examined 48 h after injection. The PBS-administered group had ,104 Ad genome copies/μ ... pAdHM4-AHAL2 was digested with PacI to release the recombinant viral genome and was transfected into 293 cells plated on 60 mm ... In order to examine the Ad vector accumulation profile in the organs, the Ad vector genome copy numbers in the organs were ...