Impairment of Coronary Vascular Reserve and ACh-Induced Coronary Vasodilation in Diabetic Patients With Angiographically Normal...
Fibroblast Growth Factor 2 Promotes Pancreatic Epithelial Cell Proliferation Via Functional Fibroblast Growth Factor Receptors ... Altered Activities of Transcription Factors and Their Related Gene Expression in Cardiac Tissues of Diabetic Rats ... Diabetes 1993 Jul; 42(7): 1017-1025. https://doi.org/10.2337/diab.42.7.1017 ...
Hepatocyte Growth Factor/Scatter Factor Has Insulinotropic Activity in Human Fetal Pancreatic Cells | Diabetes
... to threefold by hepatocyte growth factor/scatter factor (HGF/SF) basic fibroblast growth factor (FGF)-2, and to a lesser extent ... and insulin-like growth factor-II (IGF-II). In contrast, transforming growth factor-β (TGF-β) had a strong inhibitory effect. ... Hepatocyte Growth Factor/Scatter Factor Has Insulinotropic Activity in Human Fetal Pancreatic Cells. ... Hepatocyte Growth Factor/Scatter Factor Has Insulinotropic Activity in Human Fetal Pancreatic Cells ...
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Other proangiogenic factors, including basic fibroblast growth factor, hepatocyte growth factor, angiopoietin-1, and ... basic fibroblast growth factor, hepatocyte growth factor, angiopoietin-1, angiopoietin-2, TSP-1, pigment epithelium-derived ... factor, tumor necrosis factor α, platelet-derived growth factor, tissue factor, interleukin-6, and matrix metalloproteinase ( ... Interestingly, platelet-derived growth factor gene, an essential factor involved in pericyte proliferation and migration (29), ...
Human β-Cell Proliferation and Intracellular Signaling | Diabetes
... an epidermal growth factor (EGF) ligand family (EGF, betacellulin, heparin-binding EGF, amphiregulin, and trefoil factor family ... including fibroblasts, brown adipocytes, endothelial cells, and oocytes (43). More recently, the importance of PKCζ for β-cell ... This pathway integrates signals from growth factors and nutrients and controls growth (cell size), proliferation (cell number ... The growth factors (insulin, IGF-I, HGF) and the incretin hormone GLP-1 are linked to the IRS/PI3K pathway, which in turn ...
Table of Contents | Diabetes
Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K. F ... Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic ... of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. G T ... Familial and perinatal risk factors for micro- and macroalbuminuria in young IDDM patients. S Rudberg, E L Stattin and G ...
Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control | Diabetes
Fibroblast Growth Factor 2 Promotes Pancreatic Epithelial Cell Proliferation Via Functional Fibroblast Growth Factor Receptors ... To determine genetic factors involved in diabetes susceptibility in inbred strains of mice, we initially evaluated differences ... Altered Activities of Transcription Factors and Their Related Gene Expression in Cardiac Tissues of Diabetic Rats ... 7 mg/dl, P , .0001 vs. C3H/HeJ mice). Glycosylated hemoglobin of C57BL/6J mice (4.0 ± 0.06%) was also higher than that of C3H/ ...
Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis | Diabetes
Bornfeldt KE, Raines EW, Nakano T, Graves LM, Krebs EG, Ross R: Insulin-like growth factor-I and platelet-derived growth factor ... of cumene hydroperoxide and 4-hydroxynonenal on the glutathione metabolism during in vitro ageing of human skin fibroblasts. ... The effects of high glucose on human endothelial cell growth and gene expression are not mediated by transforming growth factor ... Receptors and growth promoting effects of insulin and insulin-like growth factors on cells from bovine retinal capillaries and ...
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Role of transforming growth factor Beta in corneal function, biology and pathology. Curr Mol Med 2010;10:565-578pmid:20642439. ... TGF-β3 halts fibroblast migration and selectively promotes reepithelialization in the skin wounds (46), indicating a critical ... Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Invest Ophthalmol Vis ... Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of ...
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing...
The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human ... HEK-293 cells and wild-type (WT) and AMPK knockout mouse embryo fibroblasts (MEFs) (25) were grown in DMEM with 25 mmol/L ... B: RER (VCO2/VO2) in 12-h fasted mice that had been refed a carbohydrate-rich diet for 2 h between 7:00 and 9:00 a.m. and were ... Figure 7 Liver AMPK is activated by oral administration of canagliflozin in mice, but this does not explain changes in RER. A: ...