2009). Epitope-specific Immunotherapy of Rheumatoid Arthritis: Clinical Responsiveness Occurs with Immune Deviation and Relies ... Etanercept is composed of an immunoglobulin backbone and two soluble human TNF receptors. It is typically administered ... the unique N-terminus region, the coiled-coil domain, the DNA binding domain, and the trans-activation domain (Seif et al., ... It is composed of a human antibody backbone with a mouse idiotype. Typical administration of this therapeutic is through an IV ...