Hashem Koohy - Radcliffe Department of Medicine
A robust deep learning workflow to predict CD8 + T-cell epitopes. Journal article ...
Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell...
T-cell response to a newly identified NY-ESO-1 epitope presented by H2 I-A(b). As immunization with the optimal dose of the ... Animals, Antigens, Neoplasm, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cells, Cultured, Dendritic Cells, Epitopes ... T-cell response to a newly identified NY-ESO-1 epitope presented by H2 I-A(b). As immunization with the optimal dose of the ...
Broadly cross-reactive HIV-specific cytotoxic T-lymphocytes in highly-exposed persistently seronegative donors. - Radcliffe...
... we have defined CTL responses which are specific for particular clades and have mapped some unique A clade CTL epitopes, ... we have detected CTL directed towards epitopes conserved between HIV-1 clades. In neither group is there any evidence that ... detected HLA-B35-restricted CTL which exhibit cross-reactivity between the HIV-1 and HIV-2 sequences of the CTL epitopes. In ... Amino Acid Sequence, Blood Donors, Cross Reactions, Epitope Mapping, Epitopes, B-Lymphocyte, Epitopes, T-Lymphocyte, Female, ...
Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans. - Radcliffe Department of Medicine
A cross-reactive cocktail of four antibodies, targeting the latter three non-overlapping epitopes, given on day 3 of EBOV ... The antibody response was diverse in gene usage and epitope recognition. Although close to germline in sequence, neutralizing ... A cross-reactive cocktail of four antibodies, targeting the latter three non-overlapping epitopes, given on day 3 of EBOV ... The antibody response was diverse in gene usage and epitope recognition. Although close to germline in sequence, neutralizing ...
Jack Tan - Radcliffe Department of Medicine
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2. Journal article ...
Restricted T cell receptor expression by human T cell clones specific for mycobacterial 65-kDa heat-shock protein: selective in...
Subtle differences in epitope specificity were detected for two clones with differing TcR. Once more, T cell clones with ... expression of clones specific for epitopes of mycobacterial 65-kDa heat-shock protein (hsp65) in the context of two different ... Subtle differences in epitope specificity were detected for two clones with differing TcR. Once more, T cell clones with ... We have examined the T cell receptor (TcR) expression of clones specific for epitopes of mycobacterial 65-kDa heat-shock ...
Expansion of HIV-1-specific CD28- CD45RA- CD8+ T cells in chronically HIV-1-infected individuals. - Radcliffe Department of...
CD28 Antigens, CD8-Positive T-Lymphocytes, Chronic Disease, Epitopes, HIV Infections, HIV-1, HLA-B Antigens, Humans, Leukocyte ...
Application of HLAMatchmaker computer programme to select HLA epitope matched platelets for alloimmunised thrombocytopenic...
Application of HLAMatchmaker computer programme to select HLA epitope matched platelets for alloimmunised thrombocytopenic ... Application of HLAMatchmaker computer programme to select HLA epitope matched platelets for alloimmunised thrombocytopenic ...
Rapid effector function of circulating NC16A-specific T cells in individuals with mucous membrane pemphigoid. - Radcliffe...
Autoantigens, Enzyme-Linked Immunosorbent Assay, Epitopes, T-Lymphocyte, Humans, Immunodominant Epitopes, Interferon-gamma, Non ...
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern. - Radcliffe...
... with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the ... with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the ... Epitopes, Humans, Immunity, SARS-CoV-2, T-Lymphocytes ...
CD66 identifies a neutrophil-specific epitope within the hematopoietic system that is expressed by members of the...
While YTH 71.3.2 and CE6/2D3.1 also bind to NCA-50/90, YPC 2/12.1 recognizes an epitope expressed by both the NCA-50/90 and NCA ... The YTH 71.3.2 and CE6/2D3.1 MoAbs both recognize a similar CD66 defined epitope that is distinct from that identified by YPC 2 ... While YTH 71.3.2 and CE6/2D3.1 also bind to NCA-50/90, YPC 2/12.1 recognizes an epitope expressed by both the NCA-50/90 and NCA ... The YTH 71.3.2 and CE6/2D3.1 MoAbs both recognize a similar CD66 defined epitope that is distinct from that identified by YPC 2 ...
Protective immunity to malaria: studies with cloned lines of Plasmodium chabaudi chabaudi in CBA/Ca mice. III. Protective and...
The purified preparations were then examined for the presence of specific and cross-reactive epitopes by immunoprecipitation ... A monoclonal antibody (MoAb) recognizing an epitope common to two genetically distinct cloned lines of Plasmodium chabaudi (AS ... A monoclonal antibody (MoAb) recognizing an epitope common to two genetically distinct cloned lines of Plasmodium chabaudi (AS ... The purified preparations were then examined for the presence of specific and cross-reactive epitopes by immunoprecipitation ...
Persistent immune memory of COVID-19 found in recovered patient T cells - Radcliffe Department of Medicine
T cells are attracted to tumour or viral protein fragments (called epitopes) displayed on the surface of diseased cells, which ... In this study, the researchers analysed blood samples from COVID-19 patients to identify peptides containing T cell epitopes, ... including six immunodominant regions (epitope clusters) that were targeted by T cells in many of the patients. ...
Expression of the bcl-2 oncogene product and chromosomal translocation t(14;18) in Hodgkin's disease. - Radcliffe Department of...
... protein in different subtypes of Hodgkins disease using monoclonal antibodies directed against a formalin-resistant epitope of ... protein in different subtypes of Hodgkins disease using monoclonal antibodies directed against a formalin-resistant epitope of ...
An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe...
Immunodominant Epitopes, Immunologic Memory, Male, Middle Aged, Nucleocapsid Proteins, Receptors, Antigen, T-Cell, SARS-CoV-2, ...
Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma...
Animals, Antineoplastic Agents, Alkylating, Combined Modality Therapy, Cyclophosphamide, Drug Administration Schedule, Epitopes ...
Peptide Display Company Orbit Discovery Closes £6.9M Series A Financing - Radcliffe Department of Medicine
... scientific objective was to present random peptides to T-cells with unknown specificity as a way to establish their epitopes - ...
Redirecting therapeutic T cells against myelin-specific T lymphocytes using a humanized myelin basic protein-HLA-DR2-zeta...
We generated two heterodimeric receptors that genetically link the human MBP84-102 epitope to HLA-DR2 and either incorporate or ... We generated two heterodimeric receptors that genetically link the human MBP84-102 epitope to HLA-DR2 and either incorporate or ... Epitopes, T-Lymphocyte, HLA-DR2 Antigen, Humans, Immunotherapy, Adoptive, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular ...