Selective Mineralocorticoid Receptor Blocker Eplerenone Reduces Resistance Artery Stiffness in Hypertensive Patients |...
The amount of collagen (b) and elastin (c) is expressed as collagen or elastin/total surface area as a percentage. d, Collagen/ ... Collagen and Elastin Determination. Pressurized (60-mm Hg) resistance arteries were fixed in Russell fixative and embedded in ... The media collagen/elastin ratio was reduced only after eplerenone treatment. Circulating concentrations of osteopontin, ... Figure 5. a, Imaging of staining for collagen and elastin in the wall of resistance arteries from hypertensive patients before ...http://hyper.ahajournals.org/content/51/2/432
Chromosomal Mapping of Quantitative Trait Loci Controlling Elastin Content in Rat Aorta | Hypertension
Influence of elastin gene polymorphism on the elastin content of the aorta: A study in 2 strains of rat. Arterioscler Thromb ... The distribution of elastin (percent dry weight), collagen (percent dry weight), and elastin/collagen values, as well as the ... A, Distribution of elastin and collagen values (expressed as percent of dry weight), elastin-to-collagen ratios, and ... To carefully test the possible effect of variants in the elastin gene on aortic elastin phenotypes, genotypes at the locus Eln ...http://hyper.ahajournals.org/content/45/3/460
Inflammation and the Osteogenic Regulation of Vascular Calcification | Hypertension
As with atherosclerosis, the initial calcium deposition within the tunica media may be elastin-organized phospholipid vesicles, ... Osteogenic responses in fibroblasts activated by elastin degradation products and transforming growth factor-beta1: role of ... elastin metabolism140-143; and the impact of matrix stiffness144 on the osteogenic potential of vascular mesenchymal ...http://hyper.ahajournals.org/content/55/3/579.full
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient...
Elastin in thoracic aorta section. B, Quantitation of elastin fiber breaks in aortic sections. *P,0.05 ApoE−/−/Cyp1b1+/+ AD vs ... In ApoE−/−/Cyp1b1+/+ mice on AD, the total collagen content and number of elastin breaks in aorta were increased when compared ... Treatment with TMS suppressed collagen content (Figure 2A and 2B) and prevented elastin breaks (Figure 3A and 3B). In ApoE−/−/ ... Elastin fragmentation and atherosclerosis progression: the elastokine concept. Trends Cardiovasc Med. 2013;23:211-221. doi: ...http://hyper.ahajournals.org/content/67/1/206
Body Fat Is Associated With Reduced Aortic Stiffness Until Middle AgeNovelty and Significance | Hypertension
Elastin in large artery stiffness and hypertension. J Cardiovasc Transl Res. 2012;5:264-273. ... 42 has been attributed to fatigue failure of elastin fibers;43 however in common with another MRI study, we did not observe a ... 19 Central arteries are rich in elastin that enables efficient arterial-ventricular coupling and optimal transfer of stroke ...http://hyper.ahajournals.org/content/61/6/1322
Forearm Vascular Reactivity and Arterial Stiffness in Asymptomatic Adults From the Community | Hypertension
Contribution of collagen, elastin, and smooth muscle to in vivo human brachial artery wall stress and elastic modulus. ...http://hyper.ahajournals.org/content/51/6/1512.long
Time course of arterial wall changes with DOCA plus salt hypertension in the rat. | Hypertension
The collagen and total connective tissue content of the hypertensive arteries was decreased while collagen/elastin was ...http://hyper.ahajournals.org/content/4/1/27
Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women | Hypertension
Avolio A, Jones D, Tafazzoli-Shadpour M. Quantification of alterations in structure and function of elastin in the arterial ... 37 Chronically elevated heart rate may increase large artery stiffness by accelerating elastin breakdown in the arterial wall38 ...http://hyper.ahajournals.org/content/43/6/1239
Transforming Growth Factor-β and Receptor Tyrosine Kinase-Activating Growth Factors Negatively Regulate Collagen Genes in...
Davidson JM, Zoia O, Liu J-M. Modulation of transforming growth factor-beta 1 stimulated elastin and collagen production and ... other extracellular matrix proteins such as elastin and the electrolyte content in vessels of SHR are normal. ...http://hyper.ahajournals.org/content/31/4/986
Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in...
Lungs were processed into paraffin blocks for sectioning and stained for elastin and collagen using Van Gieson and Picrosirius ... Elastin Van Giesen stain; scale bar, 50 µm) (E). Data are presented mean±SEM; n=8 to 10 per group. *P,0.05, **P,0.01, and ***P, ... elastin Van Gieson stain; scale bar, 50 µm) (E). Data are presented as mean±SEM; n=8 to 10 per group. *P,0.05, **P,0.01, and ...http://hyper.ahajournals.org/content/68/3/796
Aerobic Exercise Training Does Not Modify Large-Artery Compliance in Isolated Systolic Hypertension | Hypertension
37 through calcification and destruction of elastin. Interestingly, perindopril treatment was able to reverse the effects on ...http://hyper.ahajournals.org/content/38/2/222
Regulation of Na+,K+-ATPase α-Subunit Expression by Mechanical Strain in Aortic Smooth Muscle Cells | Hypertension
... elastin, integrin, platelet-derived growth factor, inositol 1,4,5-trisphosphate receptor, and cyclin D.28 29 30 31 32 33 ... Mechanisms of transduction of elevated vascular wall stress into increased production and accumulation of arterial elastin. ...http://hyper.ahajournals.org/content/27/3/827
Arterial Wall Hypertrophy and Stiffness in Essential Hypertensive Patients | Hypertension
... elastin, and components of the extracellular matrix. Each of these elements has its own elastic modulus, and their relative ...http://hyper.ahajournals.org/content/26/2/355
Impedance Progress | Hypertension
If present, is the increase in aortic diameter pathologic, because of elastin fragmentation and loss,6 or passive, because of ...http://hyper.ahajournals.org/content/49/6/1207
Integrins in Hypertensive Remodeling | Hypertension
The classical views explain the passive pressure-radius relation in terms of elastin and collagen fiber arrangement only, with ... muscle cells have remodeled their matrix such that during vasodilation all tension is carried by the collagen and elastin. This ...http://hyper.ahajournals.org/content/47/2/147
Physical Exercise, Aortic Blood Pressure, and Aortic Wall Elasticity and Composition in Rats | Hypertension
Matsuda et al3 showed that forced swimming in rats decreased the calcium content of elastin, increased the elastin content of ... the calcium content of elastin, the elastin content, and the elastic properties of the aortic wall were unaltered.3 All of ... A 0.1-cm sample of the abdominal aorta was removed, and the aortic wall content of the elastin-specific cross-linking amino ... Training had no effect on aortic dimensions (length, internal diameter, or wall thickness) or on wall elastin content (as ...http://hyper.ahajournals.org/content/35/4/919