Effect of Vasa Vasorum Flow on Structure and Function of the Aorta in Experimental Animals | Circulation
Elastin, collagen, collagen-to-elastin ratio, and smooth muscle cells, as well as composition and amount of extracellular ... Elastin fibers and their reticulin sheaths retain their normal appearance. C and D, Necrotic zone (zone 2 of Fig 3B⇑). Elastin ... Elastin fibers appear intact, retaining their normal sinuous pattern. C and D, Necrotic zone (zone 2 of Fig 3B⇑). Elastin ... Collagen and Elastin Content. The percentage of collagen was not different in the two groups (group A, 22.15±1.96% versus group ...http://circ.ahajournals.org/content/91/10/2669
Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E-Deficient Mice Against...
This reduced elastin degradation and accompanying aortic dilatation by loss of MMP-12 is at variance with findings of Pyo et al ... The importance of MMP-12 in elastin degradation and matrix invasion was documented in vitro24 and in pulmonary emphysema.25 Its ... TABLE 2. Elastin Degradation in ApoE−/−:MMP-9−/− and ApoE−/−:MMP-12−/− Mice ... Differences in the models may explain this apparent discrepancy, ie, MMP-12 may be more important in elastin degradation in a ...http://circ.ahajournals.org/content/109/11/1408
Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium | Circulation
Seven days after coronary artery ligation, BMSCs transfected with genes for either adeno-elastin (BMSC+Elastin) or adeno-green ... Elastin group (p,0.05 compared to BMSC and media groups). Elastin over-expression by cell-based gene therapy restored the ... Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium. Shu-Hong Li, ... Methods: Full-length elastin cDNA was generated by PCR using the human lung cDNA library, and then transfected (in adenoviral ...http://circ.ahajournals.org/content/118/Suppl_18/S_355.4
Vascular Calcification | Circulation
Elastin degradation appears early in many forms of medial calcification. Several investigators109-114 have shown that elastin ... 116 Elastin degradation is a prominent feature of aortic calcification in Marfan syndrome.117 Because an intact elastin matrix ... Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular ... This function, known as Windkessel physiology, is reflected in the high density of elastin in the arch, where mechanical energy ...http://circ.ahajournals.org/content/117/22/2938.full
Serum Elastase Activity, Serum Elastase Inhibitors, and Occurrence of Carotid Atherosclerotic Plaques | Circulation
Since elastase has been shown to degrade elastin (elastin is the most resistant fibrous protein of the organisms),3 interest ... Increased elastin-degrading activity and neointimal formation in porcine aortic organ culture: reduction of both features with ... Bizbiz L, Robert L. Micro-methods for serial determinations of elastin metabolism parameters in blood plasma and serum. Pathol ... Robert L, Robert AM, Jacotot B, Elastin-elastase-atherosclerosis revisited. Atherosclerosis. 1998; 140: 281-295. ...http://circ.ahajournals.org/content/105/22/2638
Thoracic and Abdominal Aortic Aneurysms | Circulation
The mutations result in both a decrease in the amount of elastin in the aortic wall and a loss of elastin's normally highly ... The strength of the aortic wall lies in the elastin and collagen of its extracellular matrix. Consequently, degradation of ... Indeed, certain of the matrix metalloproteinases can degrade elastin and collagen. The levels of some matrix metalloproteinases ... which is a structural protein that is the major component of microfibrils of elastin. ...http://circ.ahajournals.org/content/111/6/816.full
Prediction of the Localization of High-Risk Coronary Atherosclerotic Plaques on the Basis of Low Endothelial Shear Stress |...
Verhoeff's elastin, oil red O, and picrosirius red staining and CD45 immunostaining were performed in each cryosection for the ... Figure 7. Digital photomicrographs of Verhoeff's elastin-stained sections showing the IEL grades. Black arrowheads denote the ... where they promote the enzymatic degradation of the collagen and elastin fibers, ultimately inducing excessive wall and lumen ...http://circ.ahajournals.org/content/117/8/993
Balloon Dilation Angioplasty of Peripheral Pulmonary Stenosis Associated With Williams Syndrome | Circulation
Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome. Nat Genet. 1993;5:11-16. ...http://circ.ahajournals.org/content/103/17/2165
Skeletal Myoblasts Preserve Remote Matrix Architecture and Global Function When Implanted Early or Late After Coronary Ligation...
Overexpression of elastin fragments in infarcted myocardium attenuates scar expansion and heart dysfunction. Am J Physiol Heart ...http://circ.ahajournals.org/content/118/14_suppl_1/S130
Impaired Fibrillin-1 Function Promotes Features of Plaque Instability in Apolipoprotein E-Deficient Mice | Circulation
... role of elastin degradation peptides and the 67-kD cell surface elastin receptor. J Vasc Surg. 2002; 35: 254-261. ... Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes. J Cell Biol. 1984; 99: ... Elastin is an important component of the extracellular matrix in the vascular wall and atherosclerotic plaque. Elastic fibers ... Arrowheads indicate the presence of an elastin-rich buried fibrous cap in the ApoE−/−C1039G+/− mouse after 20 weeks of Western- ...http://circ.ahajournals.org/content/120/24/2478
Influence of External Stent Size on Early Medial and Neointimal Thickening in a Pig Model of Saphenous Vein Bypass Grafting |...
A light counterstain with elastin stain and hematoxylin was applied to permit visualization of morphology. ...http://circ.ahajournals.org/content/94/7/1741
Aerosol Gene Transfer With Inducible Nitric Oxide Synthase Reduces Hypoxic Pulmonary Hypertension and Pulmonary Vascular...
Sections (5 μm) from paraffin-embedded lungs were stained for elastin with resorcin-fuchsin solution. For each animal, 8 ...http://circ.ahajournals.org/content/102/23/2880
Abstract 19986: MicroRNA-29b is a Regulator and Therapeutic Target of Aortic Stiffness in Type 2 Diabetes | Circulation
Specifically, microRNA-29b may potentially serve as a comprehensive regulator of vascular fibrosis as well as elastin breakdown ... Vascular stiffening was accompanied by increased elastin fragmentation and collagen deposition (EvG and Picrosirius Red ... results in enhanced elastin fragmentation, increased medial collagen deposition, and increased aortic stiffness. Conversely, ... This study identifies miR-29b downregulation in diabetic vessels as a patho-mechanistic driver of vascular fibrosis and elastin ...http://circ.ahajournals.org/content/134/Suppl_1/A19986
Left Ventricular Outflow Obstruction | Circulation
Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome. Am J Hum Genet. 1995; ... In all 3 types, the underlying cause has been identified as a mutation of the elastin gene on chromosome 7q11.23.81-83 In ... The main histological feature in SVAS is the reduction in and disorganization of elastin fibers within the aortic media.84 An ... Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. J Clin Invest. 1994; 93: 1071-1077. ...http://circ.ahajournals.org/content/114/22/2412.long
Percutaneous Recanalization of Chronically Occluded Coronary Arteries | Circulation
Bartos F, Ledvina M. Collagen, elastin, and desmosines in three layers of bovine aortae of different ages. Exp Gerontol. 1979; ... Hosoda Y, Kawano K, Yamasawa F, Ishii T, Shibata T, Inayama S. Age dependent changes of collagen and elastin content in human ...http://circ.ahajournals.org/content/112/15/2364
Bioengineered Three-Layered Robust and Elastic Artery Using Hemodynamically-Equivalent Pulsatile Bioreactor | Circulation
A Student t test was used to compare the elastic modulus of the elastin and collagen regions between the 2 groups. A ... The results indicated that although ample amount of elastin was produced in the engineered vessels (Figure 4D), the amount of ... Elastica Van Gieson staining and Masson Tricrome staining demonstrated the presence of abundant elastin in the middle layer of ... In the middle layer, a significant amount of elastin was produced (D) along with dense collagen formation (F). Original ...http://circ.ahajournals.org/content/118/14_suppl_1/S52.full
Abstract 11183: Three-Dimensional Finite Element Analysis of Atherosclerotic Plaque Rupture Based on ex vivo Cryo Imaging |...
Elastin and collagen are thought to be important contributors to plaque stability, and should be assessed in future studies. ...http://circ.ahajournals.org/content/126/Suppl_21/A11183
Plaque Instability Frequently Occurs Days or Weeks Before Occlusive Coronary Thrombosis | Circulation
... collagen with or without elastin) and microcalcifications. ...http://circ.ahajournals.org/content/111/9/1160
Response to Letters Regarding Article, "Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm...
... was sufficient to induce initial elastin damage and aortic stiffening that eventually resulted in pervasive elastin ... 3 we believe that the mechanisms leading to severe aneurysmal elastin destruction and wall remodeling are not directly ... we did not find a subsequent regeneration of elastin lamellae. ...http://circ.ahajournals.org/content/133/1/e11
Abstract 5488: Granzyme B Contributes to Extracellular Matrix Degradation and Advanced Atherosclerotic Plaque Formation |...
As we have found that GrB localizes to elastic fibres, elastin binding/cleavage assays as well as ECM screening assays were ...http://circ.ahajournals.org/content/118/Suppl_18/S_559.3
Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis | Circulation
... and elastin. Light microscopic images of each section were digitized, and the surface area of the myocardium and aortic ...http://circ.ahajournals.org/content/108/24/3042
Calcific Aortic Valve Disease: Not Simply a Degenerative Process | Circulation
... and a layer rich in elastin below the inflow surface, the ventricularis, as shown in Figure 1B. The glycosaminoglycan-rich ... elastin, and amorphous extracellular matrix (predominantly glycosaminoglycans). The AV has a dense collagenous layer close to ... the cuspal tissue becomes relaxed and shortens owing to the recoil of elastin, which was elongated and taut during diastole. ...http://circ.ahajournals.org/content/124/16/1783?ijkey=8470c510ad828247d71c582caee808e0af3f46c7&keytype2=tf_ipsecsha
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises | Circulation
... reduced elastin ontent, elastin fractures, and calcification. Prominent age-associated increases in PWV have been demonstrated ...http://circ.ahajournals.org/content/107/1/139
Noninvasive In Vivo Magnetic Resonance Imaging of Experimental Coronary Artery Lesions in a Porcine Model | Circulation
... sections 5 μm thick were cut and stained with a combined Masson's trichrome elastin stain. ...http://circ.ahajournals.org/content/101/25/2956
Inhibition of Nitric Oxide but Not Prostacyclin Prevents Poststenotic Dilatation in Rabbit Femoral Artery | Circulation
Degenerative changes during PSD include a decrease in smooth muscle cell number density and elastin content and an increase in ...http://circ.ahajournals.org/content/99/8/1069