EIF-2 kinase - Wikipedia
... heme-regulated inhibitor kinase (HRI) EIF2AK2: the double-stranded RNA-dependent kinase (PKR) EIF2AK3: PEK/PERK EIF2AK4: GCN2 ... eIF-2+Kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e (Articles with ... eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals: EIF2AK1: ... These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized ...
Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase. | Profiles RNS
Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase. Biochim Biophys Acta. 2005 Sep 15; ... Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase. ... Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase. ...
Hepatitis C virus exploits cyclophilin A to evade PKR
... co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). ... eIF-2 Kinase * NS-5 protein, hepatitis C virus * Cyclophilin A Grants and funding * 272983813 - TRR 179/Deutsche ... Che C Colpitts 1 2 , Sophie Ridewood 2 , Bethany Schneiderman 2 , Justin Warne 3 , Keisuke Tabata 4 , Caitlin F Ng 2 , Ralf ... protein kinase R; viral evasion; virus; virus-host interactions. ... 2 Division of Infection and Immunity, University College London ...
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
ADAR deletion causes activation of the double-stranded RNA sensor, protein kinase R (PKR). Disruption of PKR signaling, through ... Hugh S Gannon 1 2 , Tao Zou 1 2 , Michael K Kiessling 3 4 , Galen F Gao 2 , Diana Cai 1 2 , Peter S Choi 1 2 , Alexandru P Ivan ... 2 , Francisca Vazquez 2 , Aviad Tsherniak 2 , Erez Y Levanon 5 , William C Hahn 1 2 6 7 , Matthew Meyerson 8 9 10 11 ... eIF-2 Kinase / metabolism* Substances * RNA-Binding Proteins * Interferons * EIF2AK2 protein, human ...
XBP1 | Cancer Genetics Web
... leading to the activation of c-Jun N-terminal kinase (JNK). Importantly, we found that PIM2 knockdown-induced apoptosis and ER ... 2018; 40(2):988-998 [PubMed] Related Publications X‑box‑binding protein 1 (XBP1) contributes to various types of cancer ... 2017; 436(1-2):1-12 [PubMed] Related Publications Although β-carotene is known for its anti-carcinogenic and antioxidant ... However JNK activation was not critical in the cytotoxicity of bisPMB, and ERK1/2 activation was found to play a pro-survival ...
Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA | Nature...
2 in their life cycles. In both stages, numerous specialized metabolites are produced that have roles in symbiosis and ... Chen, J. J. & London, I. M. Regulation of protein synthesis by heme-regulated eIF-2α kinase. Trends Biochem. Sci. 20, 105-108 ( ... ORCID: orcid.org/0000-0001-6048-59091,2,3,9 Show authors. Nature Microbiology volume 5, pages 1481-1489 (2020)Cite this article ... 2 Northern blot analysis of various sRNAs in X. szentirmaii.. Expression of various sRNAs in X. szentirmaii at different time ...
DeCS
Kinase, eIF-2alpha Kinase, p65 Kinase, p68 P68 Protein Kinase PKR, Protein Kinase Protein Kinase PKR Protein Kinase, DAI ... Kinase, eIF-2alpha. Kinase, p65. Kinase, p68. P68 Protein Kinase. PKR, Protein Kinase. Protein Kinase PKR. Protein Kinase, DAI ... eIF 2alpha Kinase eIF-2alpha Kinase eIF-2alpha Kinase, Heme-Regulated eRF, eIF 2 Recycling Factor eRF, eIF-2 Recycling Factor ... Kinase PKR, Protein Kinase, DAI Protein Kinase, DSRNA-Dep Protein Kinase, Heme-Regulated eIF-2alpha Kinase, P68 Protein Kinase ...
A4 Metabolic stress response and growth of GI parasites Eimeria/Giardia (Lucius/Aebischer) • "Parasite Infections: From...
The mTOR and GCN2 (an eIF-2α kinase) pathways on the host cell side are key regulators of cell growth and metabolism and can be ... IDO can be regulated by IFN-γ and we have investigated the role of the latter during infection2,3. Giardia are tightly adhering ... We have recently shown that the Indoleamine 2,3-dioxygenase 1 (IDO) pathway impacts in vivo growth of Eimeria falciformis ... 1) Schmid, M., Lehmann, M. J., Lucius, R. & Gupta, N. JBC 287, 20197-20207 (2012); (2) Rausch, S. et al. EJI 40, 2804-2815 ( ...
Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells<...
... eIF-2 Kinase/genetics",. author = "Chujun Zhang and {van Leeuwen}, Wessel and Marloes Blotenburg and Angelica Aguilera-Gomez ... Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells. Journal of Cell Science ... Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells. In: Journal of Cell ... The first is the activation of the salt-inducible kinases (SIKs; SIK2 and SIK3) by Na+ stress, which, when it is strong, is ...
Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X...
1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem ... and α-Ca2+/calmodulin-dependent kinase kinase II (α-CaMKII) (Sigma). After incubation in primary antibody overnight at 4°C, ... 2001) The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog Mol Subcell Biol 26:115- ... 1999) Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors. Eur J Neurosci 11:2073- ...
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and...
autophagy; ddr; mm; pel; upr; xbp1s; autophagy; dna damage; endoplasmic reticulum stress; protein serine-threonine kinases; ... unfolded protein response; eif-2 kinase; endoribonucleases; eukaryotic initiation factor-2 Tipologia ... Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento ... and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells. Arena A.. ;Romeo M. A.;Benedetti R.; ...
Jeffrey Langland - Scholarly Works - Arizona State University
Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is ... Activation of antiviral protein kinase leads to immunoglobulin E class switching in human B cells. Rager, K. J., Langland, J., ... Differential localization and accumulation of the plant double stranded RNA-dependent protein kinase during virus infection. ... A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR. Langland, J., ...
Nora E Sarvetnick - Research output - Research Nebraska
RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus ... Horwitz, M. S., Ilic, A., Fine, C., Balasa, B. & Sarvetnick, N., Feb 2004, In: Clinical Immunology. 110, 2, p. 134-144 11 p.. ... Yadav, D., Hill, N., Yagita, H., Azuma, M. & Sarvetnick, N., 2009, In: Cellular Immunology. 258, 2, p. 161-171 11 p.. Research ... King, C., Ilic, A., Koelsch, K. & Sarvetnick, N., Apr 16 2004, In: Cell. 117, 2, p. 265-277 13 p.. Research output: ...
Oxidative stress induces PKR-dependent apoptosis via IFN-γ activation signaling in Jurkat T cells - Fingerprint - Korea...
Dive into the research topics of Oxidative stress induces PKR-dependent apoptosis via IFN-γ activation signaling in Jurkat T cells. Together they form a unique fingerprint. ...
Wei-Chun HuangFu - 研究成果 - 臺北醫學大學
O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid ... eIF-2 Kinase 59% 56 引文 斯高帕斯（Scopus） ... Lanatoside C, a cardiac glycoside, acts through protein kinase ... Mechanistic aspects of CoII(HAPP)(TFA)2 in DNA bulge-specific recognition. Cheng, C. C., Huang-Fu, W. C., Hung, K. C., Chen, P ... Sterol O-acyltransferase 2 contributes to the yolk cholesterol trafficking during zebrafish embryogenesis. Chang, N. Y., Chan, ...
A cis-acting element in the 3'-untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein...
keywords = "3- untranslated region, Cis-acting RNA element, Protein kinase PKR, Splicing, Tumor necrosis factor", ... eIF-2 Kinase Medicine & Life Sciences 100% * 3 Untranslated Regions Medicine & Life Sciences 72% ... untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR. In: Genes and ... untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR. / Osman, Farhat; ...
Activation of p38 mitogen-activated protein kinase and c-Jun NH<sub>2</sub>- terminal kinase by double-stranded RNA and...
Protein Kinases Medicine & Life Sciences 56% * eIF-2 Kinase Medicine & Life Sciences 14% ... title = "Activation of p38 mitogen-activated protein kinase and c-Jun NH2- terminal kinase by double-stranded RNA and ... T1 - Activation of p38 mitogen-activated protein kinase and c-Jun NH2- terminal kinase by double-stranded RNA and ... terminal kinase by double-stranded RNA and encephalomyocarditis virus: Involvement of RNase L, protein kinase R, and ...
Mathews, M.<...
TOR Serine-Threonine Kinases | Harvard Catalyst Profiles | Harvard Catalyst
DNA-Activated Protein Kinase. *eIF-2 Kinase. *G-Protein-Coupled Receptor Kinases ... Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]. *TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931] ... A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the ... "TOR Serine-Threonine Kinases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
Interactions between double-stranded RNA regulators and the protein kinase DAI - Wikidata
... suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of ... Activation of the human P1/eIF-2 alpha protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator ... Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2 ... Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A ...
Heme-regulated inhibitor kinase
... kinase is a member of the eIF 2{alpha} kinase family. When heme concentrations are low in the RBC, it shuts off production of ... Heme-regulated inhibitor kinase. Heme-regulated inhibitor (HRI) kinase is a member of the eIF-2{alpha} kinase family. When heme ... Low concentrations of heme activate Heme-Regulated Inhibitor Kinase, which phosphorylates the Serine-51 of eIF-2{alpha}, and ... AMP-activated protein kinase - 5 AMP activated protein kinase or AMPK consists of three proteins (subunits) that together make ...
Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent...
Explants were also loaded in the presence of inhibitors of PKR, the fibroblast growth factor (FGF) receptor and PI3 kinase. ... PKR like endoplasmic reticulum kinase), eIF2a (eukaryotic initiation factor 2a), eEFs (eukaryotic elongation factors), and AMP- ... eIF-2 Kinase ... and AMP-dependent kinase. Explants were also loaded in the ... Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Protein Biosynthesis, RNA, Messenger, Real-Time Polymerase Chain ...
BMPR2 - wikidoc
Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ... Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic ... On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ...
Chloroquine Inhibits Heme-Dependent Protein Synthesis in Plasmodium falciparum ePrints@IISc
eIF-2-alpha kinase activity is present in the parasite lysate and is not a contaminant derived from the human erythrocytes used ... Addition of hemin plus glucose 6-phosphate or high concentrations of GTP, cAMP, and an active preparation of eIF-2 to the ... The heme-chloroquine interactive effects can also be demonstrated with purified eIF-2-alpha kinase from rabbit reticulocyte ... eIF-2-alpha) is phosphorylated in the parasite lysate to a greater extent than that observed in the control culture. Addition ...
Flashcards - Prophyrin biochemistry.txt
Cyclins | Profiles RNS
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 2009 Feb 19; ... eIF-2 Kinase. *Focal Adhesion Protein-Tyrosine Kinases. *G-Protein-Coupled Receptor Kinases ... A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They ...
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. - Radcliffe...
Using cells expressing nonfunctional PKR or reduced levels of kinase, we show that PKR is required for production of IFN-alpha/ ... However, other cytoplasmic RNA sensors, including the double-stranded RNA-binding protein kinase R (PKR), have been implicated ... eIF-2 Kinase ... Protein kinase R contributes to immunity against specific ... Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. ...
Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent...
Explants were also loaded in the presence of inhibitors of PKR, the fibroblast growth factor (FGF) receptor and PI3 kinase. ... PKR like endoplasmic reticulum kinase), eIF2a (eukaryotic initiation factor 2a), eEFs (eukaryotic elongation factors), and AMP- ... eIF-2 Kinase ... and AMP-dependent kinase. Explants were also loaded in the ... Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Protein Biosynthesis, RNA, Messenger, Real-Time Polymerase Chain ...
Profile - Overview | Scholars@IU
화학공학소재연구정보센터(CHERIC) | 연구정보 | 문헌DB | 학술지 검색
... protein kinase-like endoplasmic reticulum kinase (PERK) phosphorylation, eukaryotic initiation factor 2 alpha(eIF-2 alpha) ... Keywords:Diabetes mellitus;1,25(OH)(2)D-3;Hippocampal metabolism;ER stress;nNOS ... Biochemical and Biophysical Research Communications, Vol.490, No.2, 239-246, 2017 ...