Dendritic Glutamate Receptor mRNAs Show Contingent Local Hotspot-Dependent Translational Dynamics
Various reports have shown that hundreds to thousands of mRNAs are localized to dendrites, yet the dynamics of translation of ... Protein synthesis in neuronal dendrites underlies long-term memory formation in the brain. Local translation of reporter mRNAs ... is a primary structural regulator of the simultaneous yet differential translation of multiple mRNAs in the neuronal dendrite. ... rat hippocampal neurons demonstrates a heterogeneous distribution of translational hotspots for the two mRNAs along dendrites. ...http://su.diva-portal.org/smash/record.jsf?pid=diva2:667764
In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is...
In the cytoplasm, CBF-A localized to dendrites as well as pre- and postsynaptic sites. CBF-A was found in synaptosomal ... postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKII alpha mRNA levels; ... and CaMKII alpha mRNAs and follows the transcripts from genes to dendrites, promoting activity-dependent nuclear sorting of ...http://su.diva-portal.org/smash/record.jsf?pid=diva2:471442