Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.. Plos One. 11:e0151934.*Google Scholar ... Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor. Proceedings of the ... A gating mechanism of pentameric ligand-gated ion channels. Proc. Natl. Acad. Sci. U.s.a.. 110:E3987-3996.*Google Scholar ... Ligand-gated ion channels: new insights into neurological disorders and ligand recognition. Chem. Rev.. 112:6285-6318.*Google ...