... circulating cotinine and (ii) lung cancer risk. A total of 894 cases and 1,805 controls were analyzed for cotinine and ... after adjusting for cotinine). Variants in 7p14, 8p11, and 10q23 were not associated with cotinine or lung cancer risk. ... The directions of association for 15q25 variants with cotinine were in accordance with that expected of lung cancer risk, ... Circulating levels of the nicotine metabolite cotinine is a marker of recent smoking exposure. Hence, genetic variants ...