*  Anita T. Layton, Robert R. & Katherine B. Penn Professor of Mathematics and Professor of Biomedical Engineering
... cdc42 GTP-Binding Proteincdc42 GTP-Binding Protein, Saccharomyces cerevisiae • Cell Membrane Permeability • Cell Polarity • ... Protein BindingProtein Isoforms • Protein Transport • Quail • Rats • Rats, Inbred SHR • Rats, Wistar • Renal Circulation • ... Saccharomyces cerevisiae • Saccharomyces cerevisiae Proteins • Septins • Signal Transduction • SNARE Proteins • Sodium • Sodium ... Membrane Transport Proteins • Mice • Microvessels • Models, Animal • Models, Biological • Models, Statistical • Models, ...
  https://fds.duke.edu/db/aas/math/faculty/alayton
*  Center for Theoretical & Mathematical Sciences » People
... cdc42 GTP-Binding Proteincdc42 GTP-Binding Protein, Saccharomyces cerevisiae • Cell Membrane Permeability • Cell Polarity • ... Protein BindingProtein Isoforms • Protein Transport • Quail • Rats • Rats, Inbred SHR • Rats, Wistar • Renal Circulation • ... Saccharomyces cerevisiae • Saccharomyces cerevisiae Proteins • Septins • Signal Transduction • SNARE Proteins • Sodium • Sodium ... Membrane Transport Proteins • Mice • Microvessels • Models, Animal • Models, Biological • Models, Statistical • Models, ...
  http://fds.duke.edu/db/aas/math/ctms/faculty/alayton
*  Center for Theoretical & Mathematical Sciences » People
Carrier Proteins • Case-Control Studies • Cautery • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae • Cell Count • Cell ... Protein BindingProteins • Proto-Oncogene Proteins • Pupa • Pyrrolidonecarboxylic Acid • Quantitative Trait Loci • ... DNA-Binding Proteins • Dopamine • Dose-Response Relationship, Drug • Down Syndrome • Drosophila • Drosophila melanogaster • ... Nijhout, HF; Berg, AM; Gibson, WT, A mechanistic study of evolvability using the mitogen-activated protein kinase cascade., ...
  http://fds.duke.edu/db/aas/math/ctms/faculty/hfn
*  Anti-RAC1 + Cdc42 antibody (ab18758) | Abcam
Cdc42 antibody validated for WB. Referenced in 1 publication. Immunogen corresponding to synthetic peptide ... Ras like protein TC25 antibody. *Small GTP binding protein Cdc42 antibody. *TC25 antibody ... Cdc42/Rac is an important upstream regulator of the protein kinase cascade that controls the SAPK/JNK and p38 activity. Recent ... ab18758 detects recombinant human Rac and cdc42 proteins (Rho subfamily), and does not cross-react with members of the Ras or ...
  http://www.abcam.com/rac1-cdc42-antibody-ab18758.html
*  WNT Signaling | www.antibodies-online.com
FRZB (Frizzled-Related Protein): FRZB antibodies FRZB ELISA Kits FRZB Proteins IGFBP4 (Insulin-Like Growth Factor Binding ... This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The ... Protein 4): IGFBP4 antibodies IGFBP4 ELISA Kits IGFBP4 Proteins IGFBP5 (Insulin-Like Growth Factor Binding Protein 5): IGFBP5 ... IGFBP6 (Insulin-Like Growth Factor Binding Protein 6): IGFBP6 antibodies IGFBP6 ELISA Kits IGFBP6 Proteins ...
  https://www.antibodies-online.com/wnt-signaling-pathway-10/
*  Microtubule Dynamics | www.antibodies-online.com
This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The ... Microtubule associated proteins like MAP1, MAP2, MAP4, or MAPtau bind polymerized microtubules stabilize the polymerized form, ... Several common GTPase families like Rac and Rho promote microtubule assembly indirectly by facilitating GDP/GTP exchange on ... RHOA Proteins ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1): ROCK1 antibodies ROCK1 ELISA Kits ROCK1 Proteins ...
  https://www.antibodies-online.com/microtubule-dynamics-pathway-7/
*  Statins Inhibit β-Adrenergic Receptor-Stimulated Apoptosis in Adult Rat Ventricular Myocytes via a Rac1-Dependent Mechanism |...
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell. 1995; 81: 1137- ... The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc Natl Acad Sci U ... p21-binding domain of human PAK-1) in a total cellular protein lysate. Precipitated GTP-bound Rac1 was resolved on 4% to 20% ... Briefly, Rac activation was determined by measuring the fraction bound to a GST-PBD protein ( ...
  http://circ.ahajournals.org/content/110/4/412
*  Myosin phosphatase releases moesin-mediated inhibition. | Open-i
cdc42 GTP-Binding Protein/antagonists & inhibitors/metabolism. *rac GTP-Binding Proteins/antagonists & inhibitors/metabolism ... cdc42 GTP-Binding Protein/antagonists & inhibitors/metabolism. *rac GTP-Binding Proteins/antagonists & inhibitors/metabolism ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4322047_JEM_20140508_Fig8&req=4
*  OriGene -Protein Listing By Pathway/Family
CDC42. Transient overexpression lysate of cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 1 5 ... Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics J Transl Med 2017 [ ... Transient overexpression lysate of mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1 In Stock. ... Transient overexpression lysate of mitogen-activated protein kinase 9 (MAPK9), transcript variant JNK2-a2 5 days. ...
  http://www.origene.com/protein/listByPathways.aspx?p=2&pk=P05120
*  Plus it
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995;81:1137-46. ... The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell 2004;14:29-41. ... EPHA2 protein depletion by shRNA-mediated stable knockdown was confirmed by Western blot analysis (A). Cell viability, clonal ... Binding of EPHRINS to EPH receptors induces receptor clustering and activation. In addition to ligand-induced receptor ...
  http://cancerres.aacrjournals.org/content/74/9/2444
*  Protein Kinase Cι Is Required for Pancreatic Cancer Cell Transformed Growth and Tumorigenesis | Cancer Research
Atypical protein kinases Cλ and -ζ associate with the GTP-binding protein Cdc42 and mediate stress fiber loss. Mol Cell Biol ... Evidence that atypical protein kinase C-λ and atypical protein kinase C-ζ participate in Ras-mediated reorganization of the F- ... Protein Kinase Cι Is Required for Pancreatic Cancer Cell Transformed Growth and Tumorigenesis. Michele L. Scotti, William R. ... Protein kinase CβII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis. J Cell Biol 2002;157:915-20. ...
  http://cancerres.aacrjournals.org/content/70/5/2064
*  Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis - Danish National Research...
... cdc42 GTP-Binding Protein; rac1 GTP-Binding Protein Main Research Area: Medical science Publication Status: Published Review ... We found that Cdc42 is involved in mouse NSPC proliferation, initial dendritic development, and dendritic spine maturation. In ... These results establish cell-autonomous and stage-specific functions for the small Rho GTPases Cdc42 and Rac1 in the course of ... Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. * ...
  http://www.forskningsdatabasen.dk/catalog/235074113
*  Plus it
Hoffman GR, Nassar N, Cerione RA: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional ... after which Rac1 attains its GTP-bound active conformation via GTP/GDP exchange. ARF6.GTP singly, or in concert with Rac1.GTP, ... The monomeric, small molecular mass guanosine triphosphate (GTP)-binding proteins (G-proteins) have been shown to play ... Rac1 and Cdc42), 2) these G-proteins are bound to GDI in their GDP-bound inactive conformation and remain complexed in the ...
  http://diabetes.diabetesjournals.org/content/54/12/3523
*  Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow...
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell, 81, 1137-1146. ... D57 in Rac2 is conserved in all GTP-binding proteins and is predicted to bind the catalytic Mg2+ through an intervening water ... GEF-catalysed dissociation of GDP from Rac allows GTP binding. In the GTP-bound state, Rac is active and exerts its effects on ... B) Binding of [35S]GTPγS to GST-Rac2. GST-Rac2 was incubated for the indicated times with [35S]GTPγS. Data are expressed as ...
  http://jcs.biologists.org/content/117/2/243
*  Potential role of MCP-1 in endothelial cell tight junction `opening': signaling via Rho and Rho kinase | Journal of Cell Science
... zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss. Mol. Cell. Biol. 20, 2880-2889. ... Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations ... CCR2 is a G protein-coupled seven transmembrane receptor, and binding of MCP-1 to CCR2 could activate several different signal ... The affinity precipitation of lysed mBMEC with agarose-bound recombinant Rhotekin protein (Upstate Biotechnology, NY) and ...
  http://jcs.biologists.org/content/116/22/4615
*  Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146. [ ... However, the increase in ATF4 binding remained. In cells lacking ATF4, the levels of bound ATF2 and the increase of bound ... JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: ... Then, we progressed backwards up the signal transduction pathway and showed that the GTPase Rac1/Cdc42 and the protein Gα12 ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2786873/?lang=en-ca
*  Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin...
1995). The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137- ... 1997). Activation of the nuclear factor-κB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11, 463-475. doi:10.1101/gad.11.4.463 ... 2013). The Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin ... The Q61L-Rac1 mutant exists in a constitutively active GTP-bound form, while the T17N dominant negative adopts an inactive GDP- ...
  http://jcs.biologists.org/content/128/21/3933
*  Live cell imaging of mechanotransduction | Journal of The Royal Society Interface
Rho, Rac and Cdc42. Rho, Rac and Cdc42 are closely related small GTP-binding proteins that play important roles in ... a CaM-binding peptide and two FPs serving as a FRET pair. When Ca2+ binds to the docking sites in CaM, the bound CaM can wrap ... Under mechanical stimulation, integrin can adjust its conformation by binding to extracellular matrix proteins to form a high- ... 2004 Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. ...
  http://rsif.royalsocietypublishing.org/content/early/2010/03/29/rsif.2010.0042.focus
*  Plus it
Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS. The small GTP-binding proteins Rac1 and Cdc42 ... C and F: EGFR mRNA (C) and protein (F) levels in neonatal hearts. EGFR protein expression, phosphorylation, and mRNA levels ... The p27 promoter has several SP-1 binding sites, and p27 expression is regulated by SP-1 binding to the p27 promoter in various ... The promoter region of p27 has several SP-1 binding sites, and binding of unphosphorylated SP-1 to the p27 promoter increases ...
  http://ajpcell.physiology.org/content/296/4/C735
*  TGF-β secretion and PS-dependent engulfment of targete | Open-i
cdc42 GTP-Binding Protein/immunology. *rac1 GTP-Binding Protein/immunology. *rhoA GTP-Binding Protein/immunology ... cdc42 GTP-Binding Protein/immunology. *rac1 GTP-Binding Protein/immunology. *rhoA GTP-Binding Protein/immunology ... uptake of cells bound to the surface of the phagocyte.We propose that the phagocytosis of apoptotic cells requires two events: ... uptake of cells bound to the surface of the phagocyte.We propose that the phagocytosis of apoptotic cells requires two events: ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2198875_0108080f4c&req=4
*  Inhibition of cytokinesis by microinjection of anti-ECT | Open-i
Protein Structure, Tertiary. *Spindle Apparatus/metabolism. *cdc42 GTP-Binding Protein/metabolism. *rac1 GTP-Binding Protein/ ... ECT2 catalyzes guanine nucleotide exchange on the small GTPases, RhoA, Rac1, and Cdc42. ECT2 is phosphorylated during G2 and M ... ECT2 catalyzes guanine nucleotide exchange on the small GTPases, RhoA, Rac1, and Cdc42. ECT2 is phosphorylated during G2 and M ... Protein Structure, Tertiary. *Spindle Apparatus/metabolism. *cdc42 GTP-Binding Protein/metabolism. *rac1 GTP-Binding Protein/ ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2169345_JCB9909086.f4&req=4
*  Quantified miR-608-target interactions. (A) Target an | Open-i
B) Predicted structures and binding energy of miR-608 with AChE's C-allele and A-allele and CDC42, and of miR-132 with AChE. (C ... B) Predicted structures and binding energy of miR-608 with AChE's C-allele and A-allele and CDC42, and of miR-132 with AChE. (C ... 2E and F), predicting a hierarchical binding preference of miR-608 to the C-allele AChE, CDC42 and the A-allele AChE target ... 2E and F), predicting a hierarchical binding preference of miR-608 to the C-allele AChE, CDC42 and the A-allele AChE target ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4119407_ddu17002&req=4
*  Cdc42 and Rac1 have distinct but overlapping binding si | Open-i
Cdc42 and Rac1 have distinct but overlapping binding sites on PICK1.Upper panel: GST pulldowns were carried out using purified ... Carrier Proteins/genetics/metabolism*. *Nuclear Proteins/genetics/metabolism*. *Receptors, AMPA/metabolism*. *cdc42 GTP-Binding ... 2). Both GTPases require the presence of the BAR domain, indeed Cdc42 binds the isolated BAR domain and binding is unaffected ... 2). Both GTPases require the presence of the BAR domain, indeed Cdc42 binds the isolated BAR domain and binding is unaffected ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4300402_gr2&req=4
*  Angiotensin II Signal Transduction Through Small GTP-Binding Proteins | Hypertension
Activation of Other Small G Proteins by Ang II. Cdc42 Activation by Ang II. Cdc42 regulates formation of filopodia in the ... Small GTP-binding proteins (G proteins) are monomeric G proteins with a low molecular weight of 20 to 40 kDa. A small G protein ... Also, eIF4E is released from eIF4E binding protein/PHAS-I on phosphorylation of eIF4E binding protein/PHAS-I regulated through ... Angiotensin II Signal Transduction Through Small GTP-Binding Proteins. Haruhiko Ohtsu, Hiroyuki Suzuki, Hidekatsu Nakashima, ...
  http://hyper.ahajournals.org/content/48/4/534