This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. ... a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent ... Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. ... Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation ...

... caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases ... Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA ... this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central ... Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. This gene encodes a member of the cysteine-aspartic ...

... resulting in the induction of caspase-dependent apoptosis. The protein encoded by this gene is a member of the AKT, also called ... resulting in the induction of caspase-dependent apoptosis. The protein encoded by this gene i ...more. ...

This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. ... a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent ... Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. ... Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation ...

This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of ... cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack ...

... that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a ...