Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-...
Calcium Assays Using Cell Populations. Calcium assays were performed using Flp-In T-REx HEK293 cells harboring GPR40-YFP that ... Single Cell Calcium Assays. HEK293 cells and EF88 cells (mouse embryo fibroblasts derived from Gαq + Gα11 knockout mouse lines ... Twenty-four hours after transfection or cell treatment, cells were loaded with the calcium sensitive dye Fura-2, 1.5 μM Fura-2 ... Twenty-four hours after transfection, cells were loaded with the calcium-sensitive dye Fura-2 as above, and effect of potential ...
Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. | Molecular Pharmacology
L-type calcium channels were activated by step depolarizations from a holding potential of -60 mV to a test potential of 0 mV, ... Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels.. Y Wang and R L Rosenberg ... Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels.. Y Wang and R L Rosenberg ... Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels.. Y Wang and R L Rosenberg ...
Inhibition of Neuronal Calcium Channels by a Novel Peptide Spider Toxin, DW13.3 | Molecular Pharmacology
Inhibition of Neuronal Calcium Channels by a Novel Peptide Spider Toxin, DW13.3. Kathy G. Sutton, Chet Siok, Anthony Stea, ... Inhibition of Neuronal Calcium Channels by a Novel Peptide Spider Toxin, DW13.3. Kathy G. Sutton, Chet Siok, Anthony Stea, ... Inhibition of Neuronal Calcium Channels by a Novel Peptide Spider Toxin, DW13.3. Kathy G. Sutton, Chet Siok, Anthony Stea, ... The inhibition of different subtypes of calcium channels by DW13.3 reflects a common "macro" binding site present on all ...
Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein...
The peptides AAIGRL-NH2 and LSIGRL-NH2 triggered neither calcium nor MAP kinase signals. Neither rPAR2-Ala37-38 nor rPAR2-Leu37 ... Furthermore, the TL-derived synthetic peptide SLAAAA-NH2 failed to cause PAR2-mediated calcium signaling but did activate MAP ... Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein ... Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein ...
Increased voltage-dependent calcium influx produced by alpha 1B-adrenergic receptor activation in rat medullary thyroid...
Increased voltage-dependent calcium influx produced by alpha 1B-adrenergic receptor activation in rat medullary thyroid ... Increased voltage-dependent calcium influx produced by alpha 1B-adrenergic receptor activation in rat medullary thyroid ... Increased voltage-dependent calcium influx produced by alpha 1B-adrenergic receptor activation in rat medullary thyroid ... Increased voltage-dependent calcium influx produced by alpha 1B-adrenergic receptor activation in rat medullary thyroid ...
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Calcium was mobilized from intra- and extra-cellular sources. Oxytocin-induced calcium mobilization was dose dependent (EC50 ... Calcium transients were induced by oxytocin and the oxytocin selective analog AM-2-40 and blocked by the oxytocin-selective ... These data indicate that oxytocin-induced calcium transients in LLC-PK1 cells were not mediated by V1 or V2 vasopressin ... Calcium mobilization was a likely consequence of enhanced phosphatidylinositol turnover, because oxytocin rapidly increased the ...
Effects of Almitrine Bismesylate on the Ionic Currents of Chemoreceptor Cells from the Carotid Body | Molecular Pharmacology
1996) Regulation of ion channels in smooth muscles by calcium. Am J Physiol 271:C9-C34. ...
Latest Articles | Molecular Pharmacology
Calcium Cycling as a Mediator of Thermogenic Metabolism in Adipose Tissue Adrienne R. Guarnieri, Tyler W. Benson and Michael ... Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia ...
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2018) Redistribution of SERCA calcium pump conformers during intracellular calcium signaling. J Biol Chem 293:10843-10856. ...
Mechanisms of Inhibition of T-Type Calcium Current in the Reticular Thalamic Neurons by 1-Octanol: Implication of the Protein...
The effects of 1-octanol were also abolished by chelation of intracellular calcium ions with 1,2-bis(2-aminophenoxy)ethane-N,N, ... Mechanisms of Inhibition of T-Type Calcium Current in the Reticular Thalamic Neurons by 1-Octanol: Implication of the Protein ... Mechanisms of Inhibition of T-Type Calcium Current in the Reticular Thalamic Neurons by 1-Octanol: Implication of the Protein ... Mechanisms of Inhibition of T-Type Calcium Current in the Reticular Thalamic Neurons by 1-Octanol: Implication of the Protein ...
Table of Contents - July 01, 1981, 20 (1) | Molecular Pharmacology
Calcium-Dependent Blockade of Cardiac Cyclic AMP Accumulation by Batrachotoxin and Veratridine JOAN HELLER BROWN ...
Table of Contents - August 01, 1998, 54 (2) | Molecular Pharmacology
Inhibition of Neuronal Calcium Channels by a Novel Peptide Spider Toxin, DW13.3 Kathy G. Sutton, Chet Siok, Anthony Stea, ... Ethanol Potentiation of Calcium-Activated Potassium Channels Reconstituted into Planar Lipid Bilayers Benson Chu, Alejandro M. ...
Table of Contents - March 01, 1984, 25 (2) | Molecular Pharmacology
Tissue heterogeneity of calcium channel antagonist binding sites labeled by [3H]nitrendipine. R J Gould, K M Murphy and S H ...
Table of Contents - March 01, 1989, 35 (3) | Molecular Pharmacology
The relationship between inositol trisphosphate receptor density and calcium release in brain microsomes. S K Joseph and H L ... Differential effects of heparin on inositol 1,4,5-trisphosphate binding, metabolism, and calcium release activity in the bovine ...
Index by author - December 01, 1999, 56 (6) | Molecular Pharmacology
Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes Louis S. Premkumar ...
Table of Contents - May 01, 1994, 45 (5) | Molecular Pharmacology
Control of calcium spiking frequency in pituitary gonadotrophs by a single-pool cytoplasmic oscillator. S S Stojilkovic, M ... type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin ...
Metformin Restores Intermediate-Conductance Calcium-Activated K+ Channel- and Small-Conductance Calcium-Activated K+ Channel...
Metformin Restores Intermediate-Conductance Calcium-Activated K+ Channel- and Small-Conductance Calcium-Activated K+ Channel- ... Metformin Restores Intermediate-Conductance Calcium-Activated K+ Channel- and Small-Conductance Calcium-Activated K+ Channel- ... Correction to "Metformin Restores Intermediate-Conductance Calcium-Activated K+ Channel- and Small-Conductance Calcium- ...
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Contractions induced by calcium in the permeabilized arteries were not affected by the peptide (30 microM). Potentiation of ... These results indicate that phorbol-12,13-dibutyrate potentiates calcium-induced contractions of permeabilized coronary ... but activated protein kinase C is not a requirement for the induction of contractions by calcium alone. ... calcium-induced contractions by 1 microM phorbol-12,13-dibutyrate was partially inhibited by 10 microM peptide and was ...
Table of Contents - May 01, 1986, 29 (5) | Molecular Pharmacology
Forskolin enhances calcium-evoked prolactin release from 7315c tumor cells without increasing the cytosolic calcium ...
Index by author - January 01, 1991, 39 (1) | Molecular Pharmacology
Characterization of the slow calcium channel binding sites for [3H]SR 33557 in rat heart sarcolemmal membranes. P Chatelain, P ... Characterization of the slow calcium channel binding sites for [3H]SR 33557 in rat heart sarcolemmal membranes. P Chatelain, P ... Characterization of the slow calcium channel binding sites for [3H]SR 33557 in rat heart sarcolemmal membranes. P Chatelain, P ... Characterization of the slow calcium channel binding sites for [3H]SR 33557 in rat heart sarcolemmal membranes. P Chatelain, P ...
Amiloride Inhibition of γ-Aminobutyric AcidAReceptors Depends upon the α Subunit Subtype | Molecular Pharmacology
The cells were transfected using a calcium phosphate method optimized for the L929 cells (Chen and Okayama, 1987; Angelotti et ...
Index by author - March 01, 1988, 33 (3) | Molecular Pharmacology
Elevation of cytoplasmic calcium concentration stimulates hydrolysis of phosphatidylinositol bisphosphate in chick heart cells ... Elevation of cytoplasmic calcium concentration stimulates hydrolysis of phosphatidylinositol bisphosphate in chick heart cells ... Elevation of cytoplasmic calcium concentration stimulates hydrolysis of phosphatidylinositol bisphosphate in chick heart cells ...
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... the T149A 5-HT1A receptor mutant failed to block the influx of calcium induced by calcium channel agonist (±)-Bay K8644, ... A 2.6-fold increase in intracellular calcium (due to phospholipase C-mediated calcium mobilization) was observed for the wild- ... and to inhibition of calcium channel activation (mediated by βγ subunits of Go) but plays a minor role in coupling to αi- ... type receptor upon the addition of 100 nm 5-HT; whereas the T149A 5-HT1A receptor failed to mediate a calcium mobilization ...
Table of Contents - July 01, 2006, 70 (1) | Molecular Pharmacology
Phosducin and Phosducin-like Protein Attenuate G-Protein-Coupled Receptor-Mediated Inhibition of Voltage-Gated Calcium Channels ...
Spontaneous and γ-Aminobutyric Acid (GABA)-Activated GABAA Receptor Channels Formed by ε Subunit-Containing Isoforms |...
... were transfected with cDNAs using a modified calcium phosphate method (Angelotti et al., 1993). Plasmids encoding GABAR subtype ...
The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter...
Louis, MO) in calcium-free OR-2] and swirled at 100 rpm for 2 to 2.5 h at 18°C. After collagenase treatment, the oocytes were ... Oocytes were rinsed three times with 10 ml of calcium-free OR-2 (82.5 mM NaCl, 2 mM KCl, 1 mM MgCl2, and 5 mM HEPES, pH 7.6), ...
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Structure of the Diltiazem Receptor Site on Calcium Channels *. 5-HT and Sleep ...
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Structure of the Diltiazem Receptor Site on Calcium Channels *. 5-HT and Sleep ...
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Structure of the Diltiazem Receptor Site on Calcium Channels *. 5-HT and Sleep ...
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Structure of the Diltiazem Receptor Site on Calcium Channels Show more Accelerated Communication ...