Viruses | Free Full-Text | Modulation of Apoptotic Pathways by Human Papillomaviruses (HPV): Mechanisms and Implications for...
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. ... In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular ... have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. ... The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be ...
Molecules | Free Full-Text | Mustard Seed (Brassica nigra) Extract Exhibits Antiproliferative Effect against Human Lung Cancer...
B. nigra extract induced cellular apoptosis in a time- and concentration-dependent fashion as evidenced from increased caspase- ... apoptosis, DNA damage, cell cycle, migration, and invasion. ... Figure 2. B. nigra extract induced apoptosis in A549 and H1299 ... Figure 2. B. nigra extract induced apoptosis in A549 and H1299 lung cancer cells. Both A549 and H1299 cells were treated with B ... Apoptosis Assay. The assay was performed as previously described [58]. Caspase-3 activity was measured after treating the cells ...
Antioxidants | Free Full-Text | Ellagic Acid Prevents Binge Alcohol-Induced Leaky Gut and Liver Injury through Inhibiting Gut...
... and inflammatory liver injury in mice by inhibiting gut dysbiosis and the elevated oxidative stress and apoptosis marker ... Representative levels of apoptosis marker proteins (A) p-JNK, Bax, (B) IHC staining for cleaved caspase-3 and (C) TUNEL assay ... Representative levels of apoptosis marker proteins (A) p-JNK, Bax, (B) IHC staining for cleaved caspase-3 and (C) TUNEL assay ... Apoptosis Assay. Small intestine and liver specimens were fixed overnight in 10% buffered neutral formalin and embedded in ...
Molecules | Free Full-Text | Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer
... induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and ... Induction of Apoptosis. Apoptosis is a programmed cell death which helps to regulate cell growth and eliminate damaged cells [ ... related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines. Toxicol. In Vitro 2011, 25, 630-635. [ ... Chrysin was also shown to enhance TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis in cancer cell lines [131]. ...
Nutrients | Free Full-Text | Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer
PS may initiate apoptosis through their effects on tumor necrosis factor related apoptosis inducing ligand (TRAIL). TRAIL has ... Beta Sitosterol and Apoptosis. β-Sitosterol has been demonstrated to activate Fas. In both MCF-7 and MDA-MB-231 cells, both the ... Muenchen, H.J.; Lin, D.L.; Walsh, M.A.; Keller, E.T.; Pienta, K.J. Tumor necrosis factor-alpha-induced apoptosis in prostate ... Awad, A.B.; Downie, A.C.; Fink, C.S. Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB- ...
IJMS | Free Full-Text | Possible Pathogenesis and Prevention of Long COVID: SARS-CoV-2-Induced Mitochondrial Disorder
... and apoptosis [136]. The permeabilization of mitochondria is critical for apoptosis and regulated necrosis [130,131,137]. ... Apoptosis [42] Antagonizing the IFN signaling pathway [43] Interacts with MHC-I [24] IFN I antagonist [44] Activates IL-17 ... The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Cell. Mol. Immunol. 2020, 17, 881-883. [Google Scholar] [CrossRef] ... Green, D.R.; Reed, J.C. Mitochondria and apoptosis. Science 1998, 281, 1309-1312. [Google Scholar] [CrossRef] [PubMed] ...
Nutrients | Free Full-Text | Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention
... all involved in apoptosis induction. In PCa, these miRNAs are generally downregulated, favoring the inhibition of apoptosis and ... Detailed analysis of expression and promoter methylation status of apoptosis-related genes in prostate cancer. Apoptosis 2010, ... Apoptosis, cell cycle arrest and reduced invasive capacity. [139]. Flavanones. Silibinin. DU145, PC3 cells. ↓ EZH2, ↑ DNMT. ↓ ... Apoptosis is a form of programmed cell death caused by a set of precise cellular events that change the morphology and the ...
Cells | Free Full-Text | Vitamin D and Ovarian Cancer: Systematic Review of the Literature with a Focus on Molecular Mechanisms
Apoptosis, anti-proliferative effect, ↓migration. [47]. Hou (2016). In vitro. ↑E-cadherin, ↓Vimentin, ↓β-catenin. ↓Metastatic ... Apoptosis (synergistic effect with carboplatin). [44]. Lungchukiet (2015). In vitro. In vivo. NA. Suppress ovarian cancer ... The effect of 1,25(OH)2D on ovarian cancer cell apoptosis has also been reported [29]. 1,25(OH)2D has been shown to ... Apoptosis. [42]. Kavandi (2012). In vitro. ↓CXCL1, ↓CXCL2. ↓ Expression of proinflammatory cytokines → downregulation of ...
IJMS | Free Full-Text | Protective Effects of Rhodiola Crenulata Extract on Hypoxia-Induced Endothelial Damage via Regulation...
RCE Protects Endothelial Cells from Hypoxia-Induced Apoptosis To examine the effects of RCE on hypoxia-induced apoptosis, the ... Tan, C.B.; Gao, M.; Xu, W.R.; Yang, X.Y.; Zhu, X.M.; Du, G.H. Protective effects of salidroside on endothelial cell apoptosis ... El Solh, A.A.; Akinnusi, M.E.; Baddoura, F.H.; Mankowski, C.R. Endothelial cell apoptosis in obstructive sleep apnea: A link to ... Endothelial apoptosis contributes to many features of endothelial dysfunction, and apoptotic vascular endothelial cells have ...
IJMS | Free Full-Text | Establishment of Human-Induced Pluripotent Stem Cell-Derived Neurons-A Promising In Vitro Model for a...
2.2.2. RABV Induced Various Levels of Apoptosis Depending on hiPSC-Derived Cell Types. Apoptosis was implicated in RABV ... To examine apoptosis in each cell type by flow cytometry, (A) NPCs at different stages included undifferentiated NPCs, and NPCs ... To examine apoptosis in each cell type by flow cytometry, (A) NPCs at different stages included undifferentiated NPCs, and NPCs ... Figure 4. RABV infection induced apoptosis in hiPSC-derived NPC but not neurons and astrocytes. Cells were infected with RABV- ...
Molecules | Free Full-Text | Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin...
... indicating the inhibition of apoptosis pathways in the kidneys. We also applied the network pharmacological analysis and ... identified multiple targets of 3DC2ME related to MAPK signaling pathway and apoptosis. ... and apoptosis pathways. Cisplatin-induced LLC-PK1 cell death was most significantly reduced following treatment with 3- ... Apoptosis has most frequently been referred to in cisplatin-induced renal cell death. In this study, apoptosis was observed ...
Diseases | Free Full-Text | A Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs)
Apoptosis; TNF-alpha Signaling via NF-kB; IL-2/STAT5 Signaling; Complement; Reactive Oxygen Species Pathway (Figure 6). ... apoptosis regulators (CASP3 and CFLAR) G-protein GNAI2, matrix metalloproteinase MMP2 and matrix metalloproteinase inhibitor ...
Viruses | Free Full-Text | RNA-Sequencing Analysis of 5' Capped RNAs Identifies Many New Differentially Expressed Genes in...
Although this included pathways reported in previous studies, such as apoptosis, sphingolipid metabolism and amino acid ... These studies have identified alterations in biologic pathways including TGF-beta signaling, apoptosis, cellular metabolism, ... apoptosis, lipid metabolism, and intracellular transport genes in the replication of hepatitis C virus. J. Virol. 2010, 84, ... apoptosis, and fibrosis under experimental conditions [9]. The majority of enriched KEGG pathways were observed at 72 hours ...
IJMS | Free Full-Text | Curcumin and Weight Loss: Does It Work?
Apoptosis at 30 μM. ↓Glycerol release. ↓MAPK phosphorylation. 2 and 24 h [121]. ... Curcumin possesses the ability to modulate the core pathways involved in cancer cell proliferation, apoptosis, cell cycle ... inhibition of adipogenesis and induction of mature adipocyte apoptosis. ...
Pharmaceuticals
... apoptosis; mitochondria; cell death; cell calcium. Special Issues, Collections and Topics in MDPI journals Special Issue in ...
Nutrients | Free Full-Text | Molecular Bases Underlying the Hepatoprotective Effects of Coffee
HSC apoptosis. ↓ HSC procollagen type 1c, α-SMA. ↓ liver TGF-β, α-SMA. ... studies reporting in vitro effects on metabolic processes without assessing effects on cell steatosis or apoptosis (pure ...
Cells | Free Full-Text | Low-Intensity Blue Light Exposure Reduces Melanopsin Expression in Intrinsically Photosensitive...
... and caused outer segment vesiculation and outer nuclear layer apoptosis. Ultrastructural analysis showed that LTE damaged ... and with terminal deoxynucleotidyl transferase dUTP nick-end labelling for apoptosis detection. LTE reduced the length of Opn4- ... Increased Apoptosis in ONL of Rats Subjected to LTE and STE to Blue Light. In control retinas, only isolated apoptosis signals ... Note: no labelling for apoptosis. (B) Retina from a rat in the STE group. Isolated nuclei display labelling for apoptosis ( ...
Inorganics | Free Full-Text | Concise Review of Nickel Human Health Toxicology and Ecotoxicology
Apoptosis/Autophagy. Increase [109,112,113,114,115]. Increase via increased expression of caspase 8 in workers [116]. ... and apoptosis, e.g., [250,251,252,253,254,255,256,257]. Recent inhalation studies indicate possible differences in ... is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. Toxicol. Appl. Pharmacol. 2013, ... Involvement of histone hypoacetylation in Ni2+-induced bcl-2 down-regulation and human hepatoma cell apoptosis. J. Biol. Inorg ...
IJMS | Free Full-Text | Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer
CBD enhances apoptosis and decreases cell proliferation.. [118]. Brain tumor. SH SY5Y. IMR-32. √. 10 µM. CBD induces apoptosis ... CBD induces cancer cell apoptosis. [90]. Brain tumor. U87. U373. √. 5-10 µM. CBD induces apoptosis through activation of ... CBD induces cancer cells apoptosis. [97]. Breast cancer. SUM-159. √. √. 3-18 µM. CBD induces both apoptosis and autophagy- ... CBD induces apoptosis through the production of ROS. [114]. Brain tumor. U251. SF126. √. IC50 = 1.1-1.3 µM. 0.4 µM. CBD induces ...
Cells | Free Full-Text | Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia
Increase in myoblast apoptosis. Serum from CRC patients. [155,157]. Sarcopenia: ↑. IL6. PTEN. FOXO3. Decrease of myogenesis. ... Increase in apoptosis. Venuss blood and muscle samples from sarcopenia patients (ages 55-82). [171]. ... showed that tumor-derived microvesicles were able to induce apoptosis of skeletal muscle cells via their miR-21 cargo, which ... and apoptosis pathways [188]. Furthermore, Li et al. demonstrated the potential of bone marrow stem cell-derived exosomes (BMSC ...
Cancers | Free Full-Text | Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial...
Positive regulation of apoptosis, regulation of cell cycle. PARP2. FAM20. NM_005484.3. c.910G,C. p.(Glu304Gln). 3/6. −. 3/ ... Positive regulation of apoptosis. LATS2. H460. NM_014572.3. c.337G,A. p.(Asp113Asn). 5/6. −. 1/56,138. Ubiquitin-associated ... Positive regulation of apoptosis. RECQL. H466. NM_002907.4. c.221_225delinsAATGT p.(Pro74_Trp75delinsGlnCys). 6/6. +. 0/60,706 ... DNA repair, apoptosis, autophagy, cell growth, cell proliferation, inflammatory response, cell cycle, angiogenesis, cell ...
Viruses | Free Full-Text | Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
Yen, J.H.; Ganea, D. Interferon beta induces mature dendritic cell apoptosis through caspase-11 / caspase-3 activation. Blood ... promotes apoptosis of plasmacytoid dendritic cells. Am. J. Transplant. 2006, 6, 2332-2341. [Google Scholar] [CrossRef] [PubMed] ...
Toxins | Free Full-Text | The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1...
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner ... In conclusion, resveratrol can inhibit the proliferation of 4T1 cancer cells by inhibiting cell cycle and inducing apoptosis. ... Figure 5. The apoptosis of 4T1 cells was detected by flow cytometry. (A-F) Apoptosis stage diagram of 4T1 cells after 48 h ... Figure 5. The apoptosis of 4T1 cells was detected by flow cytometry. (A-F) Apoptosis stage diagram of 4T1 cells after 48 h ...
IJMS | Free Full-Text | Targeting ERK-Hippo Interplay in Cancer Therapy
Apoptosis 2006, 11, 337-346. [Google Scholar] [CrossRef] [PubMed]. *Finlay, D.; Howes, A.; Vuori, K. Critical role for caspase- ... BH3 mimetics induce apoptosis independent of DRP-1 in melanoma. Cell Death Dis. 2018, 9, 907. [Google Scholar] [CrossRef] ... Induction of apoptosis by cisplatin in HeLa and HL-60 cells was dependent on activation of the ERK signaling and NOXA ... MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nat. Med. 2014, 20, 385-397. [Google Scholar] [ ...
Cells | Free Full-Text | Oxidative Stress Is Associated with Overgrowth in Drosophila l(3)mbt Mutant Imaginal Discs
Furthermore, we show the presence of oxidative stress in l(3)mbt hyperplastic discs, even in apoptosis-blocked conditions, but ... Mollereau, B.; Ma, D. The p53 control of apoptosis and proliferation: Lessons from Drosophila. Apoptosis 2014, 19, 1421-1429. [ ... Figure 4. Apoptosis and ROS production in mbt-RNAi wing discs. (A,B) Wing disc from mbt-RNAi mutant larvae of 6 dAEL (A) and 7 ... Figure 4. Apoptosis and ROS production in mbt-RNAi wing discs. (A,B) Wing disc from mbt-RNAi mutant larvae of 6 dAEL (A) and 7 ...
Nutrients | Free Full-Text | Pentadecanoic Acid, an Odd-Chain Fatty Acid, Suppresses the Stemness of MCF-7/SC Human Breast...
... and promoted caspase-dependent apoptosis in MCF-7/SC. These findings indicate that pentadecanoic acid can serve as a novel JAK2 ... Pentadecanoic Acid Induced Apoptosis in MCF-7/SC. Evading apoptosis is one of the key characteristics of cancer cells [44,45]. ... Apoptosis 2005, 10, 619-630. [Google Scholar] [CrossRef] [PubMed]. *von Schwarzenberg, K.; Vollmar, A.M. Targeting apoptosis ... Apoptosis in MCF-7/SC was detected using the annexin V-FITC Apoptosis Detection Kit following the suppliers instructions. ...
Nutrients | Free Full-Text | Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle...
... inducing cancer cell apoptosis [2]; and antihypertensive [3], cholesterol-lowering [4], anti-inflammation [5], antimicrobial [6 ... Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemiaderived cells by modulation of NF- ...
IJMS | Free Full-Text | The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review
Cellular apoptosis pathway. mitochondrial apoptosis. Apoptotic Pathways in Synovial Fibroblasts. p53 Mediated Apoptosis. DHA ... Interestingly, BDNF has main biological roles in inflammation and apoptosis; thus, it is a crucial neurotrophic factor for ... Strangely, BDNF has leading biological roles in inflammation and apoptosis; consequently, it is a crucial neurotrophic factor ... Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis. J. ...
IJMS | Free Full-Text | An Integrated Transcriptomic Approach to Identify Molecular Markers of Calcineurin Inhibitor...
Apoptosis 2007, 13, 11-32. [Google Scholar] [CrossRef] [PubMed]. *Palacín, M.; Coto, E.; Llobet, L.; Pacheu-Grau, D.; Montoya, ... Holcik, M.; Sonenberg, N. Translational control in stress and apoptosis. Nat. Rev. Mol. Cell Biol. 2005, 6, 318-327. [Google ... Servais, H.; Ortiz, A.; Devuyst, O.; Denamur, S.; Tulkens, P.M.; Mingeot-Leclercq, M.-P.; Arduan, A.O. Renal cell apoptosis ... apoptosis of kidney cells (z-score = 2.052), involving upregulation of TGFB1, TLR4, CSF1, and GFPT1 genes, in addition to ...
Molecules | Free Full-Text | The Lactoferrin Phenomenon—A Miracle Molecule
... inducing cell apoptosis and their degeneration, which leads to the development of many diseases, including cancer. Among the ... apoptosis and inflammation. It suppresses the senescence and apoptosis of mesenchymal stem cells (MSCs) [102,103], promotes ... Apoptosis 2019, 24, 562-577. [Google Scholar] [CrossRef]. *Mariller, C.; Benaïssa, M.; Hardivillé, S.; Breton, M.; Pradelle, G ... Grey, A.; Zhu, Q.; Watson, M.; Callon, K.; Cornish, J. Lactoferrin potently inhibits osteoblast apoptosis, via an LRP1- ...