... activity. Some aporphine alkaloids (such as crebanine) have been found to present arrhythmic activity (irregularities in the ... Some derivatives of aporphine such as (S)-(+)-N-propylnorapomorphine have potential as low side effect profile antipsychotics ... claims to contribute to anti-cancer activity. The study of Chi P. Ndi et al., (2016) illustrates the antiproliferative and ... "Synthesis and Structure-Activity Relationships of a Series of Aporphine Derivatives with Antiarrhythmic Activities and Acute ...

... synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the ... Tryptamine alkaloids, Methyl esters, Quinolizidine alkaloids, Vinca alkaloids, Heterocyclic compounds with 5 rings). ... It has been investigated as novel anticancer drug. Concerns over long-term use have been documented by the National Toxicology ... "Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamines Biological Activity". Journal of Medicinal ...

... of compounds that are under current study due to their potential as anti-cancer drugs and the prospective number of derivatives ... biological activity, biosynthesis, and laboratory synthesis. Indolocarbazoles belong to the alkaloid sub-class of bisindoles. ... Anti-Cancer Agents. 2 (2): 255-266. doi:10.2174/1568011023354218. PMID 12678746. Knubel G.; Larsen L. K.; Moore R. E.; Levine I ... Numerous forms have tested positive for anti-tumor activity, such as 7-hydroxy-STA and 7-oxo-STA2. Some of the strains from ...

Aaghaz S, Sharma K, Jain R, Kamal A (April 2021). "β-Carbolines as potential anticancer agents". European Journal of Medicinal ... "Antioxidant activity of beta-carboline derivatives". Acta Poloniae Pharmaceutica. 68 (2): 185-189. PMID 21485291. Gulyaeva N, ... β-Carbolines belong to the group of indole alkaloids and consist of a pyridine ring that is fused to an indole skeleton. The ... Synthetically designed β-carboline derivatives have recently been shown to have neuroprotective, cognitive enhancing and anti- ...

Anti-cancer and anti-viral activity was subsequently observed for swainsonine-a mannose analogue-and castanospermine-a glucose ... DNJ was modified to produce two derivatives now used as medicines, N-hydroxyethyl-DNJ (miglitol) for diabetes and N-butyl-DNJ ( ... Amino sugar Watson AA, Fleet GW, Asano N, Molyneux RJ, Nash RJ (2001). "Polyhydroxylated alkaloids-natural occurrence and ... an increasing number are being shown to have therapeutic potential without being glycosidase inhibitors and may interact with ...

α-Hederin and also its derivative, kalopanaxsaponin-I, have been studied for their anticancer activities. α-Hederin has been ... 1f), saponin (a potential anticancer agent), vitamins (riboflavin, thiamin, niacin, pyridoxine, folic acid, and vitamin E), and ... 1d), isoquinoline alkaloids (nigellicimine and nigellicimine-N-oxide, Fig. 1e), alpha-hederin (a water-soluble pentacyclic ... One of the derivatives of alpha-hederin, kalopanaxsaponin-I, was found to possess anticancer activity ... Alpha-hederin also, ...

Oroidin analogues have anticancer, antiparasitic, and antibiofilm activities and therefore are a potential drug candidate for ... Alkaloid Natural products Forenza, S.; Minale, L.; Riccio, R.; Fattorusso, E. (1971). "New bromo-pyrrole derivatives from the ... Its complex structure leads to wide biological activities, which makes Oroidin a potential drug candidate for various diseases ... Researchers have synthesized many Oroidin derivatives to improve the biological activities. Adding additional side chains and/ ...

"Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives". Journal of the American ... Its cytotoxicity makes it a potential anticancer compound. Communesin B is a dimeric indole alkaloid with a hexadienoyl moiety ... to form the core structure of communesin alkaloids. CnsE transfers a methyl group to the indole nitrogen, and CnsJ creates an ... "Elucidation of the concise biosynthetic pathway of the communesin indole alkaloids". Angewandte Chemie. 54 (10): 3004-3007. doi ...

CPT showed anticancer activity in preliminary clinical trials, especially against breast, ovarian, colon, lung, and stomach ... Chung MK, Han SS, Kim JC (August 2006). "Evaluation of the toxic potentials of a new camptothecin anticancer agent CKD-602 on ... New Light on Alkaloid Biosynthesis and Future Prospects. Academic Press. 27 July 2013. pp. 143-149. ISBN 978-0-08-099411-6. ( ... DB-67 is a 10-hydroxy derivative and is among the most active silatecans. BNP1350 which belongs to the series of karenitecins ...

Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or ... been discovered in screening programs and developed as chemotherapy drugs Some plants that indicate potential as an anticancer ... Cardenas, ME; Cruz, MC; Del Poeta, M; Chung, N; Perfect, JR; Heitman, J (1999). "Antifungal activities of antineoplastic agents ... Catharanthus roseus Vinca alkaloids were originally manufactured by extracting them from Catharanthus (Madagascar Periwinkle). ...

In addition, gelsemine has been noted to have anti-inflammatory and anti-cancer activities. Recent research on gelsemine has ... Conroy H, Chakrabarti JK (January 1959). "NMR spectra of gelsemine derivatives. The structure and biogenesis of the alkaloid ... Pharmacological research has suggested gelsemine activities to have potential related to the treatment of anxiety, and in ... Liu ZJ, Lu RR (1988). "Gelsemium Alkaloids" (review). The Alkaloids: Chemistry and Pharmacology. The Alkaloids. Vol. 33. San ...

"Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and ... Studies showed that palmatine had antioxidant activity, had a protective effect on gastric ulcer, derivatives of palmatine were ... Deng, Yecheng; Zhang, Ming; Luo, Haiyu (May 2012). "Identification and antimicrobial activity of two alkaloids from traditional ... In addition, palmatine also had anti-cancer activity on MCF-7, U251, KB, CHOK-1, HT-29 and SiHacell lines. Palmatine induced ...

Mahmoudian M, Rahimi-Moghaddam P (January 2009). "The anti-cancer activity of noscapine: a review". Recent Patents on Anti- ... Noscapine is itself an anti-mitiotic agent, therefore its analogs have great potential as novel anti-cancer drugs. Analogs ... Li Y, Smolke CD (July 2016). "Engineering biosynthesis of the anticancer alkaloid noscapine in yeast". Nature Communications. 7 ... 3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents". Journal of Molecular Graphics & Modelling. 106 ...

Anidulafungin is a derivative of an Aspergillus metabolite.[citation needed] Many mushrooms contain potential antiviral ... and sparassol are under research for their potential antibiotic activity.[citation needed] Statins are an important class of ... Psychoactive ergot alkaloid drugs have subsequently been extracted from or synthesised starting from ergot; these include ... Ina K, Kataoka T, Ando T (June 2013). "The use of lentinan for treating gastric cancer". Anti-Cancer Agents in Medicinal ...

BIAdb: A Database for Benzylisoquinoline Alkaloids. The Benzylisoquinoline Alkaloid Database is an attempt to gather the ... This is a potential drug target involved in bacterial cell wall synthesis. This server uses molecular docking and QSAR ... KetoDrug:A web server for binding affinity prediction of ketoxazole derivatives against Fatty Acid Amide Hydrolase (FAAH). It ... CancerDR: CancerDR is a database of 148 anticancer drugs and their effectiveness against around 1000 cancer cell lines. ...

2003). The Alkaloids: Chemistry and Biology. California: Academic Press. pp. 1-50. ISBN 978-0080521497. Pommier Y (October 2006 ... Aditi and Williams) Pommier Y, Leo E, Zhang H, Marchand C (May 2010). "DNA topoisomerases and their poisoning by anticancer and ... Topotecan is a semi-synthetic derivative of camptothecin. Camptothecin is a natural product extracted from the bark of the tree ... The study suggested that the topoisomerase inhibitors have the potential to produce a normally functioning UBE3A protein. Most ...

4-oxadiazoles as a New Series of Apoptosis Inducers and Potential Anticancer Agents". Journal of Medicinal Chemistry. 48 (16): ... A. F. Shepard; Winslow, N. R.; Johnson, John R. (1930). "The simple halogen derivatives of furan". J. Am. Chem. Soc. 52 (9): ... The total synthesis of (−)-neothiobinupharidine, a bioactive alkaloid isolated from Nuphar pumila (the small yellow pond-lily) ... Patent 246,107 (1987) Han-Zhong Zhang; Kasibhatla, Shailaja; Kuemmerle, Jared (2005). "Discovery and Structure-Activity ...

Moronic acid, another compound found in the plant, shows also potential anti-HIV activity. An injectable oil emulsion form of ... ISBN 0-939616-42-4. Roberts, M. F. (1994). "Brucea SPP.: In Vitro Culture and the Production of Canthinone Alkaloids and Other ... Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents". Journal of Medicinal Chemistry. 49 (18): 5462- ... It contains quassinoid compounds called bruceolides that are anticancer and antiparasitic. It is traditionally used to treat ...

Potential for Prostate Cancer Management". Anticancer Research. 30 (3): 857-865. PMID 20393007. Leu, Chien-Hsing; Li, Chia-Ying ... The indole alkaloid has also been found in the roots of the young dioecious trees.[citation needed] Dye extracted from the bark ... a tert-amyl alcohol derivative of kaempferol 7-O-glucoside, can be found in P. amurense. Leaf Tree Bark Seeds Amur cork tree ... demonstrated significant free radical scavenging activity comparable to vitamin E. The tree has both antibiotic and ...

Swainsonine also has potential uses as an adjuvant for anti-cancer drugs and other therapies in use. In mice, swainsonine ... Indolizidine alkaloids, Experimental cancer drugs, Indolizidines, Triols, Alkaloids found in Fabaceae, Suspected female ... Gardner, DR; Cook, D (2016). "Analysis of Swainsonine and Swainsonine N-Oxide as Trimethylsilyl Derivatives by Liquid ... Swainsonines activity against tumors is attributed to its stimulation of macrophages. ...

Activity Relationship Analysis of Novel Derivatives of Narciclasine (an Amaryllidaceae Isocarbostyril Derivative) as Potential ... Martin, S.F. (1987). "3: The Amaryllidaceae Alkaloids". In Brossi, Arnold (ed.). The Alkaloids. The Alkaloids: Chemistry and ... Anticancer Agents". Journal of Medicinal Chemistry. 52 (4): 1100-1114. doi:10.1021/jm8013585. PMID 19199649. Carmen Altomonte ... Despite the lethal potential of Narcissus alkaloids, they have been used for centuries as traditional medicines for a variety ...

August 2019). "In silico identification of natural products with anticancer activity using a chemo-structural database of ... A synthetic derivative acetylsalicylic acid better known as aspirin is a widely used pain reliever. Its mechanism of action is ... Plants were the main source of such compounds, especially alkaloids and glycosides. It was long been known that opium, a sticky ... Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in ...

Asif, M. Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives, ... substituted derivatives have been synthesized for medicinal purposes such as antimalarial and anticancer agents. Quinazoline is ... Nelson MH, Dolder CR (February 2006). "Lapatinib: a novel dual tyrosine kinase inhibitor with activity in solid tumors". Ann ... Over 200 biologically active quinazoline and quinoline alkaloids are identified. The synthesis of quinazoline was first ...

Dragamine has been studied, for example as a potential anti-cancer agent, for its antimalarial activity and in antifertility ... Plant metabolites have long been studied for their biological activity and alkaloids in particular are major subjects for ... "Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells". European Journal of Medicinal ... Conodurine Vincamine Neuss, N.; Cone, Nancy J. (1959). "Alkaloids of apocynaceae IV. Dregamine, a new alkaloid from Voacanga ...

Lipase inhibitors have also shown anticancer activity, by inhibiting fatty acid synthase. Pancreatic lipase inhibitor was ... Due to this FAS is a potential drug target in cancer therapy. Orlistat works locally in the intestines as a lipase inhibitor, ... These include alkaloids, carotenoids, glycosides, polyphenols, polysaccharides, saponins and terpenoids. However, none of these ... Tetrahydrolipstatin, more commonly known as orlistat, is a saturated derivative produced by hydrogenation. It was developed in ...

"Synthesis and anticancer activity studies of cyclopamine derivatives". Bioorganic & Medicinal Chemistry Letters. 18 (4): 1359- ... solanidine alkaloids, (2) verazine alkaloids, (3) veratramine alkaloids, (4) jervine alkaloids, and (5) the cevanine alkaloids ... it never reached therapeutic potential as it caused many side effects including weight loss, dehydration, and death in mouse ... "Experimental Anti-cancer Drug Kills Brain Tumor Stem Cells". ScienceDaily (Press release). August 31, 2007. Tabs S, Avci O ( ...

Tabernaemontanine has been studied, for example as a potential anti-cancer agent, for its antimalarial activity and in ... "Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells". European ... Plant metabolites have been of interest for their possible biological activity and alkaloids in particular are major subjects ... Alkaloids of Tabernaemontana and Ervatamia. The Structure of Coronaridine, A New Alkaloid Related to Ibogamine". Journal of the ...

The Vinca alkaloids vincristine and vinblastine, used as anti-cancer drugs, were discovered in the 1950s from the Madagascar ... These phytochemicals have potential for use as drugs, and the content and known pharmacological activity of these substances in ... "Laxative potency and acute toxicity of some anthraquinone derivatives, senna extracts and fractions of senna extracts". ... that these plant groups do have potential for medicinal efficacy, 2) that undefined pharmacological activity is associated with ...

It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities. A number ... Imidazole and its derivatives have high affinity for metal cations. One of the applications of imidazole is in the purification ... Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature ... and evaluation of potential inhibitors of nitric oxide synthase" (PDF). Bioorg. Med. Chem. (Submitted manuscript). 16 (11): ...

In contrast, some of its derivatives display binding activity to the enzyme topoisomerase II (Topo II) during the late S and ... Ardalani H, Avan A, Ghayour-Mobarhan M (2016). "Podophyllotoxin: a novel potential natural anticancer agent". Avicenna Journal ... It is a non-alkaloid toxin lignin extracted from the roots and rhizomes of Podophyllum species. A less refined form known as ... Ardalani H, Avan A, Ghayour-Mobarhan M (2017-06-01). "Podophyllotoxin: a novel potential natural anticancer agent". Avicenna ...