Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat...
... inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci 30:3184-3198. ... 2010) Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner. J Biol ... 2009) Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. J ... 2009) {alpha}-Synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells. J Biol Chem 284 ...
Parkinson's disease | Journal of Neuroscience
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions ... Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked ...
Table of Contents - January 13, 2016, 36 (2) | Journal of Neuroscience
Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinsons Disease in Human Alpha-Synuclein A53T ...
Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and...
Molecular Mechanisms of the Conjugated alpha,beta-unsaturated Carbonyl Derivatives: Relevance to Neurotoxicity and ... a-synuclein) or environmental toxicants (e.g., organochlorine insecticides). With respect to the latter possibility, it is ... Molecular Mechanism of Glyceraldehyde-3-Phosphate Dehydrogenase Inactivation by alpha,beta-Unsaturated Carbonyl Derivatives. ...
Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and...
Molecular Mechanisms of the Conjugated alpha,beta-unsaturated Carbonyl Derivatives: Relevance to Neurotoxicity and ... a-synuclein) or environmental toxicants (e.g., organochlorine insecticides). With respect to the latter possibility, it is ... Molecular Mechanisms of the Conjugated alpha,beta-unsaturated Carbonyl Derivatives: Relevance to Neurotoxicity and ... Molecular Mechanism of Glyceraldehyde-3-Phosphate Dehydrogenase Inactivation by alpha,beta-Unsaturated Carbonyl Derivatives. ...
Plus it
2001) Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons. Exp Neurol 169:219-230. ... including α-synuclein and parkin (Langston, 1998;Polymeropoulos, 1998; de Silva et al., 2000). Unlike its familial counterpart ...