*  Optimizing Biochemical Biomarkers for PD Research | Parkinson's Disease
to transfer alpha-synuclein and DJ-1 kits that exist in academic laboratories to a setting where the kit can be carried out in ... Alpha-synuclein and DJ-1 are proteins that appear to change in people with Parkinson's disease. The current methods of ... We anticipate there will be a standardized "kit" that Covance will offer as a service for the detection of alpha-synuclein and ... detecting alpha-synuclein and DJ-1 in blood and cerebrospinal fluid require specialized tools that are only available to a few ...
  https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=673
*  Alpha-Synuclein Detection: ELISAs and Antibodies
Alpha-Synuclein Detection. Synuclein family members (alpha-, beta-, and gamma-synuclein) are expressed at high levels in adult ... Alpha-synuclein (C‑terminus). 18671A, B. IHC. WB. Human. (S122). Rabbit IgG. Cross‑reacts with mouse and rat alpha-synuclein. ... ELISAs for Alpha-Synuclein Detection. The human alpha-synuclein assay kit (Cat. # 27740A) is a solid-phase sandwich ELISA using ... Antibodies for Alpha-Synuclein Detection. Anti-human alpha-synuclein antibody (Cat. # 18671A, B) is an affinity-purified IgG ...
  http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Brain_and_CNS/Alpha-Synuclein?sitex=10020:22372:US&PEBCL1=7l5uwvG92P7mvnVVdfRJ5R3C3C&PEBCL1_pses=ZGE118626BB0E9861AA82736AC8AEF11AD56B05A5E18CCD6B4F2964846C4D03CBA7757FC0FA1326F25330AC51CAA304C3DDED0D21C7C0DBF1A
*  Anti-amyloid Oligomer Monoclonal Antibodies for Treatment of Parkinson's Disease | Parkinson's Disease
If we find antibodies that are specific for alpha-synuclein oligomers and synuclein aggregates, we plan to test them in pre- ... Alpha-Synuclein Therapeutics, 2010. Objective/Rationale: The goal of this project is to evaluate the interaction of a panel of ... The goal of this proposal is to identify antibodies that are specific for the pathology of alpha synuclein in Parkinson s ... For some of these antibodies, we have already shown that interact with alpha-synuclein aggregates in vitro. In this project, we ...
  https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=791
*  IJMS | Free Full-Text | High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors
In Parkinson's disease, this process involves the aggregation of alpha-synuclein (α-syn) into intraneuronal inclusions. Thus, ... "High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors." Int. J. Mol. Sci. 18, no. 3: 478. ... In Parkinson's disease, this process involves the aggregation of alpha-synuclein (α-syn) into intraneuronal inclusions. Thus, ... High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors. Jordi Pujols 1. ...
  http://www.mdpi.com/1422-0067/18/3/478
*  Extracellular alpha-synuclein contributes to gsk-3beta-dependent Tau phosphorylation in PC12 dopaminergic cells: Its role in...
extracellular alpha-synuclein glycogen synthase kinase 3beta Tau protein phosphorylation dopaminergic cell pathomechanism ... Extracellular alpha-synuclein contributes to gsk-3beta-dependent Tau phosphorylation in PC12 dopaminergic cells: Its role in ... alpha-synuclein pathogenesis neurodegenerative disorder cyclin dependent kinase real-time polymerase chain reaction ...
  http://agro.icm.edu.pl/agro/element/bwmeta1.element.agro-04276cee-7551-4a24-ae16-96773c63bd2a
*  "Alpha-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport i" by Nandhakumar Thayanidhi, Jared R. Helm et al.
... indicating that alpha-synuclein antagonizes SNARE function. Ykt6 reversed alpha-synuclein inhibition much more effectively than ... Finally, soluble alpha-synuclein A53T directly bound ER/Golgi SNAREs and inhibited SNARE complex assembly, providing a ... Overexpression of wild type or the familial disease-associated A53T mutant alpha-synuclein delayed transport by up to 50%; ... We tested elements of this hypothesis by expressing human alpha-synuclein in mammalian kidney and neuroendocrine cells and ...
  https://scholarworks.umt.edu/biosci_pubs/60/
*  Anti-Alpha-synuclein antibody (ab15530) | Abcam
Rabbit polyclonal Alpha-synuclein antibody validated for ICC/IF and tested in Human and Rat. Referenced in 4 publications. ... Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine ... Synthetic peptide corresponding to Human Alpha-synuclein aa 111-131 (C terminal).. Sequence: GILEDMPVDPDNEAYEMPSEE ... A 6.4 Mb duplication of the a-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations ...
  http://www.abcam.com/alpha-synuclein-antibody-ab15530.html
*  Anti-Alpha-synuclein antibody (ab93432) References
References for Abcam's Anti-Alpha-synuclein antibody (ab93432). Please let us know if you have used this product in your ...
  http://www.abcam.com/alpha-synuclein-antibody-ab93432-references.html
*  Human Alpha-synuclein peptide (ab105629) | Abcam
Buy our Human Alpha-synuclein peptide. Ab105629 is a blocking peptide for ab93432 and has been validated in BL. Abcam provides ... Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine ...
  http://www.abcam.com/human-alpha-synuclein-peptide-ab105629.html
*  Pathology Outlines - Alpha-synuclein
Member of the synuclein family of soluble proteins (alpha-synuclein, beta-synuclein and gamma-synuclein) that are commonly ... Alpha-synuclein. Author: Meenakshi Vij Gupta, M.D. (see Authors page). Revised: 23 May 2016, last major update May 2016. ... Both the sporadic and the familial form of Alzheimer disease also demonstrate alpha-synuclein protein * In recent years, ... several studies have shown that alpha-synuclein aggregation can also be detected outside the central nervous system, ...
  http://pathologyoutlines.com/topic/stainsalphasynuclein.html
*  Anti-Alpha-synuclein antibody (ab15530) Protocols | Abcam
Abcam provides specific protocols for Anti-Alpha-synuclein antibody (ab15530) : Immunocytochemistry & immunofluorescence ...
  http://www.abcam.com/alpha-synuclein-antibody-ab15530-protocols.html
*  Anti-Alpha-synuclein antibody [syn204] (ab3309) | Abcam
Mouse monoclonal Alpha-synuclein antibody [syn204] validated for WB, IP, ICC/IF and tested in Human. Referenced in 3 ... Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine ... Addition of exogenous a-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous a-synuclein ... Synuclein alpha 140 antibody. *Synuclein, alpha (non A4 component of amyloid precursor) antibody ...
  http://www.abcam.com/alpha-synuclein-antibody-syn204-ab3309.html
*  alpha-synuclein Archives - Neuroscience News
T cells may be tricked into thinking dopamine neurons are foreign due to the build up of damaged alpha-synuclein, a new study ... Researchers detail the complex interaction between alpha synuclein and the prion protein PrPc.... Read More... ... The drug, nortiptyline, has been shown to stop the growth of alpha synuclein.... Read More... ... The Nature study reports four genetic variations are associated with T cell reactivity to alpha synuclein. More than 50% of ...
  http://neurosciencenews.com/neuroscience-terms/alpha-synuclein/
*  Phospho anti-alpha Synuclein (Y125) antibody (ab194771) | Abcam
Rabbit polyclonal alpha Synuclein (phospho Y125) antibody validated for WB, ICC/IF and tested in Human. Immunogen corresponding ... Anti-Alpha-synuclein (phospho Y125) antibody. See all Alpha-synuclein primary antibodies. ... All lanes : Anti-Alpha-synuclein (phospho Y125) antibody (ab194771) at 1/500 dilution. Lane 1 : C2C12 untreated. Lane 2 : C2C12 ... Phospho specific peptide corresponding to residues surrounding Tyrosine 125 of Human alpha Synuclein.. Database link: P37840 ...
  http://www.abcam.com/alpha-synuclein-phospho-y125-antibody-ab194771.html
*  Alpha-synuclein (phospho S129) antibody [EP1536Y] Recombinant (ab51253)
Rabbit recombinant monoclonal Alpha-synuclein antibody [EP1536Y] validated for WB, IHC, ICC/IF and tested in Human, Mouse and ... Dot blot analysis of alpha Synuclein (pS129) peptide (Lane 1), alpha Synuclein (unmodified) peptide (Lane 2) labelling alpha ... Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y]. See all Alpha-synuclein primary antibodies. ... Sarkosyl-insoluble brain extract from mice transgenic for PrPA53T alpha-synuclein (line M83). Lane 2 : Recombinant alpha- ...
  http://www.abcam.com/alpha-synuclein-phospho-s129-antibody-ep1536y-ab51253.html?productWallTab=Abreviews
*  Alpha-synuclein Expression Lowering therapeutics: Hit Confirmation | Parkinson's Disease
Alpha-synuclein Expression Lowering therapeutics: Hit Confirmation. MJFF Research Grant, 2011. Objective/Rationale:. Simply ... To rid brains of Parkinson's patients of alpha-synuclein toxicity one can attempt to clear the protein from the brain, block ... Brains of most patients with Parkinson's are littered with intracellular accumulations of alpha-synuclein, a small 140 amino- ... or ameliorate the consequences of alpha-synuclein toxicity. We hypothesize, that the most direct and acute solution, however, ...
  https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=983
*  Saliva Alpha-synuclein Levels in LRRK2 Mutation Carriers | Parkinson's Disease
Saliva Alpha-synuclein Levels in LRRK2 Mutation Carriers. Research Grant, 2014. Study Rationale: Biomarkers are needed to ... Decreased levels of alpha-synuclein in cerebrospinal fluid is the most consistent biological marker of PD to date; however, ... We will measure and compare alpha-synuclein levels in the saliva of LRRK2 mutation carriers who do not have any PD symptoms ( ... Human salivary alpha-synuclein could be a reliable, inexpensive, easily accessible biomarker to 1) assist with early PD ...
  https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=1429
*  Alpha-synuclein transfers from neurons to oligodendrocytes.
... Reyes, Juan F LU ; Rey, Nolwen LU ; Bousset, Luc; Melki, Ronald; ... The origin of α-synuclein (α-syn)-positive glial cytoplasmic inclusions found in oligodendrocytes in multiple system atrophy ( ... The origin of α-synuclein (α-syn)-positive glial cytoplasmic inclusions found in oligodendrocytes in multiple system atrophy ( ... article{dce8851e-e03f-4e93-90bb-913db60219ed, abstract = {The origin of α-synuclein (α-syn)-positive glial cytoplasmic ...
  https://lup.lub.lu.se/search/publication/4292243
*  Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] Review (64512) | Abcam
... for Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] used in IHC - Wholemount. Abcam provides excellent in-house ... IHC - Wholemount abreview for Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y]. Excellent ...
  https://www.abcam.com/Alpha-synuclein-phospho-S129-antibody-EP1536Y-ab51253/reviews/64512
*  anti-alpha Synuclein antibody [4D6] | GeneTex
... synuclein, alpha (non A4 component of amyloid precursor)) for ELISA, IHC, IHC-Fr, IHC-P, WB. Anti-alpha Synuclein mAb (GTX21903 ... synuclein, alpha (non A4 component of amyloid precursor). Background. The implication of alpha synuclein in neurodegenerative ... The synuclein family includes alpha and beta synucleins and loosely related gamma synuclein and synoretin. The expression is ... alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kD) are small highly conserved proteins ...
  http://www.genetex.com/alpha-Synuclein-antibody-4D6-GTX21903.html
*  TSRI - News & View, Scientists 'Watch' as Individual Alpha-Synuclein Proteins Change Shape
To comply with the National Institutes of Health (NIH) Public Access Policy, a PubMed Central reference number (PMCID) is required in NIH grant applications, proposals, and progress reports for any paper "authored by you or [arising] from your NIH funds (even if you are not an author)" (see http://publicaccess.nih.gov/FAQ.htm#c8).. One way to find the PMCID number is to use PubMed Central's PMID: PMCID Converter available at http://www.ncbi.nlm.nih.gov/sites/pmctopmid. If you already have the PMID from a PubMed search (it may appear as the Accession Number in your EndNote library), the above converter will provide you with the corresponding PMCID to include in your grant. If you do not have the PMID number, you can look up a PMCID in PubMed. It will be listed in the lower right corner of the AbstractPlus view. A PMCID number will be assigned as soon as an article has successfully been submitted to PMC (see http://publicaccess.nih.gov/FAQ.htm#c9). If you have questions about the NIH Public Access ...
  http://www.scripps.edu/newsandviews/e_20090323/updates.html
*  Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] Question (63686) | Abcam
... for Abcam's Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y]. Our in-house scientific support team are here to help you ...
  http://www.abcam.com/Alpha-synuclein-phospho-S129-antibody-EP1536Y-ab51253/questions/63686
*  Alpha-synuclein and Cognitive Decline in Parkinson s Disease | Parkinson's Disease
... synuclein immunoreactivity by genotype/haplotype, and to correlate alphasynuclein genetic variability, gene and protein ... Alpha-synuclein (SNCA) genetic variability has been implicated in many susceptibility studies of idiopathic Parkinson s disease ... Variability in the SNCA gene (which encodes alpha-synuclein, the protein that clumps in Parkinson s disease) is a major risk ... In post-mortem patient brains we will also evaluate the genetic contribution of SNCA to gene expression and alpha-synuclein ...
  https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=1314
*  Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain | Journal of Neuroscience
2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34:521 ... 2003) Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies. Acta ... Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain. Weili Yang, Guohao Wang, Chuan-En Wang, Xiangyu Guo ... Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain. Weili Yang, Guohao Wang, Chuan-En Wang, Xiangyu Guo ...
  http://www.jneurosci.org/content/35/21/8345