A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength | PNAS
... robust response suggests that inhibition of signaling through BMPR1A with mBMPR1A-mFc represents a promising unique therapeutic ... Human SaOS-2 cells (a human osteosarcoma-derived osteoblast cell line) were treated for 20 min with BMP2 and/or mBMPR1A-mFc ( ... the murine BMPR1A extracellular domain (ECD) (residues Q24-R152), and the murine IgG2A-Fc domain (mIgG2A-Fc). (B) Kinetic ... 1 B and C). BMP6/7 and GDF5/6 also bound to mBMPR1A-mFc, but with up to 50-fold lower affinity. TGFβ1, TGFβ2, and TGFβ3 did not ...