Development of a Prognostic Model Based on Pyroptosis-Related Genes in Pancreatic Adenocarcinoma
A miRNA-prognostic DEPRG-transcription factor (TF) regulatory network was created via the miRNet online tool. A risk score ... The microenvironments of the low- and high-risk groups were assessed using xCell, the expression of immune checkpoints was ... However, the efficacy of using pyroptosis-related genes (PRGs) in predicting the prognosis of pancreatic adenocarcinoma (PAAD) ... Based on the risk score and other independent prognostic indicators, a nomogram with a good ability to predict the survival of ...
Tumor Purity Coexpressed Genes Related to Immune Microenvironment and Clinical Outcomes of Lung Adenocarcinoma
Tumor purity plays an essential role in the immune response to lung cancer. At present, the biological processes related to the ... immune cells, and epithelial cells. These nontumor cells dilute the tumor purity in lung cancer tissues. ... purity of lung cancer tumors remains unclear. ,i,Methods,/i,. We measured tumor purity in 486 lung carcinoma tissues from TCGA- ... i,Purpose,/i,. Lung cancer tissue includes tumor tissue, stromal cells, ...
Postchemoradiotherapy Neutrophil-to-Lymphocyte Ratio Predicts Distant Metastasis and Survival Results in Locally Advanced...
i,Conclusion,/i,. The present study found that the posttreatment NLR ≥3.1 was independently linked with a higher risk of DM and ... for locally advanced pancreatic adenocarcinoma (LAPAC). ,i,Materials and Methods,/i,. Our retrospective research included a sum ... 3.1 were found to be independent predictors of poor prognosis in the multivariate analysis. , ... Lymphocyte counts and functions are major determinants of the hosts anti-cancer immune response to tumor cells and hence ...
Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma
i,Conclusions,/i,. Neurovascular-related NRP family genes are significantly correlated with cancer prognosis, TME, and immune ... and stomach adenocarcinoma (STAD) was associated with poor prognosis. A high NRP2 expression in bladder urothelial carcinoma ( ... Subsequent analyses showed that NRP1 and NRP2 were correlated with immune infiltration and immune checkpoints. Genome-wide ... BLCA), kidney renal papillary cell carcinoma (KIRP), and mesothelioma (MESO) was associated with poor prognosis. Moreover, NRP1 ...
Neurotoxicity of Tumor Immunotherapy: The Emergence of Clinical Attention
... thereby enhancing treatment efficiency and improving the prognosis of patients. At present, the mechanism of neurotoxicity ... However, the accumulation of evidence suggests that immunotherapy also induces severe and complex neurologic immune-related ... It is a dose-limited factor of cancer immunotherapy and affects the prognosis and quality of life [15]. The incidence of the ... D. J. Byun, J. D. Wolchok, L. M. Rosenberg, and M. Girotra, "Cancer immunotherapy-immune checkpoint blockade and associated ...
Partial Oxygen Pressure Affects the Expression of Prognostic Biomarkers HIF-1 Alpha, Ki67, and CK20 in the Microenvironment of...
... and cell proliferation factor Ki67. The levels of pO,sub,2,/sub, were negatively associated with the size of CRC tissues. ... staining was conducted by using the avidin-biotin complex technique for detecting the antibodies to hypoxia inducible factor-1 ... Hypoxia is prognostically important in colorectal cancer (CRC) therapy. Partial oxygen pressure (pO,sub,2,/sub,) is an ... H. Sun, C. Wang, M. Hao et al., "CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer ...
High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer
High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different ... with special reference to ovarian and prostate cancer. Their participation in the molecular mechanisms of resistance to ... Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. These cells also develop ... expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p. 27. kip1. regulation in LNCaP and ...
MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma
... accurate prognosis, and molecular targets for future treatment. This study aimed to evaluate the expression levels of miR-34a ... Recent studies reported microRNAs as promising biomarkers for early cancer detection, ... "Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic ... "The role of TGF-beta-1 protein and TGF-beta-R-1 receptor in immune escape mechanism in bladder cancer," MedGenMed, vol. 9, p. ...
Genetic Polymorphism of E2F1 Influences Susceptibility to Ovarian Cancer in a Chinese Population
E2F1 gene rs3213173 and rs3213176 polymorphisms confer no risk to ovarian cancer risk. The CT genotype of E2F1 gene rs3213172 ... and rs3213176 polymorphisms of the E2F1 gene confer risk for ovarian cancer. ,i,Methods.,/i, A total of 80 patients with ... and E2F1 gene rs3213172 polymorphism may be a novel marker for the risk prediction of ovarian cancer. ... polymorphism is associated with an increased risk of ovarian cancer, ...
Identification and Validation of Autophagy-Related Gene Nomograms to Predict the Prognostic Value of Patients with Cervical...
In this study, we constructed risk signatures of autophagy-related genes (ARGs) to predict the prognosis of cervical cancer. ... Immune cells with an enrichment score of 28 showed statistically significant differences related to high and low risk. GSEA ... Our constructed autophagy risk signature may be a prognostic tool for cervical cancer. ... In the training set, the survival rate of the high-risk group was lower than that of the low-risk group (,svg xmlns:xlink=http ...
Vitamin D Receptor Gene Polymorphisms and the Risk of CIN2+ in Shanxi Population
Vitamin D receptor (VDR) gene polymorphism is considered to be an important cause of cancer development. Here, we studied the ... were associated with the risk of CIN2+. No haplotype was associated with CIN2+ risk. According to the results, FOKI and TaqI ... Human papillomavirus (HPV) infection is the primary cause of cervical cancer, of which HPV 16 is the predominant. Early ... Cervical cancer is one of the most common malignancies in women with high morbidity and mortality. ...
Significance of the Expression of TC and TG Levels in the Initial Diagnosis and Treatment of SCLC Patients and Their Tie-In...
For SCLC patients, the risk factors affecting the prognosis of patients with progression-free survival include newly diagnosed ... Combined TC and TG detection can be used as indicators to predict the prognosis of the patients. TC and TG are significantly ... correlated with the prognosis of the patients with progression-free survival time. It is worthy of clinical application. ... the expression of TC and TG levels in the initial diagnosis and treatment of SCLC patients and their tie-in with prognosis. ...
Oncosuppressive Role of RUNX3 in Human Astrocytomas
Runt-related transcription factor 3 (,i,RUNX3,/i,) is feasible tumour suppressor gene since its inactivation was shown to be ... However, molecular targets that could provide reliable diagnostic and prognostic information on this type of cancer are ... "Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer," Oncogene, vol. 34, no. 22, ... were an independent indicators increasing the risk of patient death. Low RUNX3 protein level increases event risk by 1,33-fold ...
Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal...
... were independent prognostic factors for PFS of patients with mCRC. The elevated LDH (HR=2.204, 95%CI=1.000-4.858, P=0.050 ... 69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the ... were independent prognostic factors for OS of patients with mCRC.,i, Conclusions,/i,. Taken together, our results implicate ... i,Aim,/i,. To identify the population of patients with high risk of distant metastasis and the poor prognosis before treatment ...
Prognostic Assessment of Oxidative Stress-Related Genes in Colorectal Cancer and New Insights into Tumor Immunity
Cox regression analysis using single and multiple variables revealed that OXEG-related signals were independent risk factors ... Patients with CRC were categorized into low-risk and high-risk groups according on their median risk scores. ... Prognostic risk models were built using multivariate Cox regression analysis, univariate Cox regression analysis, and LASSO ... For validation, 65 samples of colon cancer from GSE29621 were utilized. For the purpose of choosing prognostic genes, the ...
Dual Effects of Cigarette Smoke Extract on Proliferation of Endothelial Progenitor Cells and the Protective Effect of 5-aza-2...
... is well known to be a risk factor for pulmonary diseases including chronic obstructive pulmonary disease (COPD), lung cancer, ... E. G. Tzortzaki, A. Papi, E. Neofytou, N. Soulitzis, and N. M. Siafakas, "Immune and genetic echanisms in COPD: possible ... "The role of DNA methylation in the development and progression of lung adenocarcinoma," Disease Markers, vol. 23, no. 1-2, pp. ... "Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell ...
How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications
... wild-type cancers and comprise a distinct colorectal cancer subgroup. This review highlights the importance of the ,i,BRAF,/i, ... A proportion of the ,i,BRAF,/i, mutant lesions remain as microsatellite stable (MSS), and in contrast to the MSI cancers, they ... of sporadic colorectal cancer. This is an early event in serrated pathway tumourigenesis, and the ,i,BRAF,/i, V600E has been ... mutation occurring in colorectal cancer stratified for molecular background and discusses its prognostic and clinical ...
Can CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?
... serum CA-125 levels in predicting pelvic or paraaortic lymph node metastasis in patients operated for epithelial ovarian cancer ... Many tumor markers have been studied for screening and tumor progression in ovarian cancer. The cancer cell or the immune ... "Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status," Cancer ... X. Xu, Y. Wang, F. Wang et al., "Nadir CA-125 level as prognosis indicator of high-grade serous ovarian cancer," Journal of ...