Corticotropin-Releasing Hormone Induces Vascular Endothelial Growth Factor Release from Human Mast Cells via the cAMP/Protein...
Using highly selective inhibitors of adenylate cyclase, protein kinase A, and p38 MAPK, we found that stimulation of the cAMP/ ... of mitogen-activated protein kinase kinase, the upstream kinase of the extracellular signal-regulated protein kinase (ERK) or ... CRH binding to CRH-R1 typically activates adenylate cyclase, which leads to increased intracellular concentrations of cAMP and ... phosphate-buffered saline; PAGE, polyacrylamide gel electrophoresis; H89, N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline; ...