Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 ... Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) ... Data show that downregulating proto-oncogene protein Akt (p-Akt) by inhibiting PP2A inhibitor SET-mediated protein phosphatase ... The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits ...https://pharos.nih.gov/idg/targets/Q01105
Blockade of PD-1/B7-H1 Interaction Restores Effector CD8+ T Cell Responses in a Hepatitis C Virus Core Murine Model | The...
To examine the underlying mechanism of HCV core protein in the alteration of host immune responses to viral infection in the ... 1⇑B, the core protein (21 kDa) was detected in core(+) mice but not in core(−) mice. Interestingly, the expression of HCV core ... The dotted box indicates cDNA encoding the HCV core protein. B, Expression of core protein in core(+) mice. Liver samples from ... 6⇓A). Treatment of core(+) mice with B7-H1 blocking Ab reduced viral Ag load by ,5-fold in core(+) mice when compared with core ...http://www.jimmunol.org/content/180/7/4875.long
Expression of HCV Core Protein in Insect Cells and Evaluation 0f Its Im munological properties -- Vol. 11, No 04, 1996 --...
... baculoviruses containing gene of HCV core protein were obtained by plaque screening.Therecombinant HCV core proteins(20 kD)were ... and the recombinant protein ean elicited specific anti-HCV antibody in ani-mals. ... Full-length cDNA coding HCV core protein was isolated from human HCV positiveserum by RT-PCR and inserted into baculovirus ... Chronic Viral Infections and Immunomodulation. Structural Virology. Cyanophage and Algal Virus. Emerging Viral Diseases ...http://www.virosin.org/Paper/1996/11/04/VS19961104.0325
Interaction between the core protein and STAT3. (A) In | Open-i
Interaction between the core protein and STAT3. (A) In vitro binding experiment. HepG2 cell extracts stimulated with (+) or ... DNA-Binding Proteins/metabolism*. *Hepacivirus/genetics/pathogenicity*/physiology*. *Trans-Activators/metabolism*. *Viral Core ... HCV core protein is proposed to be responsible for the virus-induced transformation. We now report that HCV core protein ... HCV core protein is proposed to be responsible for the virus-induced transformation. We now report that HCV core protein ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2194001_20012127f3&req=4
Anti-Hepatitis C Virus Core 1a antibody (ab93664)
Rabbit polyclonal Hepatitis C Virus Core 1a antibody (ab93664) validated for WB, ELISA and tested in RecFrag. Immunogen ... HCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in ... The N terminus of the core protein is involved in transcriptional repression. HCV core protein is among the most conserved ... The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is ...http://www.abcam.com/hepatitis-c-virus-core-1a-antibody-ab93664.html
AID 755109 - Antiviral activity against HCV JFH-1 infected in human Huh7.5.1 cells assessed as viral core protein expression at...
Antiviral activity against HCV JFH-1 infected in human Huh7.5.1 cells assessed as viral core protein expression at 0.8 to 8 uM ...https://pubchem.ncbi.nlm.nih.gov/bioassay/755109
Viruses | Free Full-Text | Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral...
Here, we provide electron microscopy-based data demonstrating the association of both nuclear capsids and NEC proteins at ... The latter has been studied intensely pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a ... Specifically, immunogold labelling of the core NEC constituent pUL53 and NEC-associated viral kinase pUL97 suggested an ... Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. ...http://mdpi.com/1999-4915/10/1/35
Split responses of the F5 transgenic T cells to peptid | Open-i
F5 spleen cells (2 × 105/well) were stimulated with given concentration of the viral peptides or control P1A peptides for 48 h ... F5 spleen cells (2 × 105/well) were stimulated with given concentration of the viral peptides or control P1A peptides for 48 h ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199130_JEM.971488f1a&req=4
Role of Adenovirus Core Proteins in Innate Signaling and Viral Genome Packaging - Patrick Hearing
The major Ad core protein, protein VII, protects the viral genome from recognition by the DDR immediately after infection. As ... Role of Adenovirus Core Proteins in Innate Signaling and Viral Genome Packaging Hearing, Patrick State University New York ... Core protein VII is tightly associated with the viral genome within the Ad virus particle, the capsid. It is not clear how ... Role of Adenovirus Core Proteins in Innate Signaling and Viral Genome Packaging. Hearing, Patrick / State University New York ...http://grantome.com/grant/NIH/R21-AI102577-02
Cross-reactive cells are oligoclonal T memory cell expa | Open-i
RNA-Binding Proteins*. *Viral Core Proteins/genetics*/immunology. Minor. *Animals. *Cell Division ... Selective expansion of cross-reactive CD8(+) memory T cells by viral variants. ... Selective expansion of cross-reactive CD8(+) memory T cells by viral variants. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195685_JEM991162.f3b&req=4
Assembly Pharmaceuticals and BioCrossroads Announce Investment to Advance Potentially Curative Therapy for Chronic Hepatitis B...
BioCrossroads Joins Twilight Ventures, Luson Bioventures and Other Investors- -Breakthrough Anti-viral Science Is Based on ... "Our HBV drug candidates modulate the viral core protein. By altering the core protein's functions across multiple stages in the ... which target the HBV core protein, a unique viral protein with no human analogue that is involved in multiple stages of the HBV ... CpAMs can alter the activities of the HBV core protein, a unique viral protein with no human analogue that is involved in ...https://www.biocrossroads.com/assembly-pharmaceuticals-biocrossroads-announce-investment-advance-potentially-curative-therapy-chronic-hepatitis-b-virus/
Set - Protein SET - Mus musculus (Mouse) - Set gene & protein
Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 ... Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF- ... Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti- ... Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 ...http://www.uniprot.org/uniprot/Q9EQU5
Anti-SET antibody (ab92872) | Abcam
Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ... Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF- ...http://www.abcam.com/set-antibody-ab92872.html
Both NXF1 and p15 can contribute to the efficient nucle | Open-i
RNA-Binding Proteins/genetics/metabolism*. *Viral Core Proteins/genetics/metabolism*. Minor. *Active Transport, Cell Nucleus/ ... Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery. ... Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery. ... Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4215830_pone.0106683.g006&req=4
Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97 |...
Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97. ... Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97 ... pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a multimeric assembly of viral and ... herpesviral nuclear egress nuclear egress complex (NEC) viral protein kinase pUL97 immunogold-electron microscopy NEC-capsid ...https://repository.medri.uniri.hr/en/islandora/object/medri%3A1974
"T cells with regulatory activity in hepatitis C virus infection: what " by Angela Dolganiuc and Gyongyi Szabo
Animals; Hepacivirus; Hepatitis C; Humans; Immunity, Cellular; T-Lymphocytes, Regulatory; Viral Core Proteins ...https://escholarship.umassmed.edu/oapubs/1927/
'genes gag' Protocols and Video...
Genes, gag: DNA sequences that form the coding region for proteins associated with the viral core in retroviruses. gag is short ...https://www.jove.com/keyword/genes+gag
CiNii 論文 - C型肝炎ウイルス
Supression of hepatitis B viral expression and replication by hepatitis C viral core protein in HuH-7cell line SHIH C. M. ... Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing TANJI Y. ... Expression of processed core protein of hepatitis C virus in mammalian cells HARADA S. ... Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus ...https://ci.nii.ac.jp/naid/10008543883
"Hepatitis C core and nonstructural 3 proteins trigger toll-like recept" by Angela Dolganiuc, Shilpa Oak et al.
CONCLUSIONS: HCV core and NS3 proteins trigger inflammatory pathways via TLR2 that may affect viral recognition and contribute ... Although cellular uptake of core and NS3 proteins was independent of TLR2 expression, cell activation required TLR2. HCV core ... The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 proteins. METHODS: ... RESULTS: HCV core and NS3 proteins triggered inflammatory cell activation via the pattern recognition receptor TLR2 and failed ...https://escholarship.umassmed.edu/gastroenterology_pp/40/
"Subversion of plasmacytoid and myeloid dendritic cell functions in chr" by Gyongyi Szabo and Angela Dolganiuc
... we demonstrated that TLR2 but not TLR4 was critical in recognition of HCV core and NS3 proteins by innate immune cells. Further ... MDC functions are impaired in patients with chronic HCV infection and DC defects are likely related to interaction of HCV viral ... TLR2 recognition of HCV core and NS3 was not augmented by co-expression of the TLR co-receptor, CD14. These data demonstrate ... Our experiments revealed that MDC defects can be induced by HCV core and NS3 proteins suggesting virus-induced mechanisms for ...https://escholarship.umassmed.edu/gastroenterology_pp/44/
Effects of Blocking Individual Maturation Cleavages in Murine Leukemia Virus Gag
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly. EMBO J. 17:1555-1568. [PubMed ... viral maturation involves not only a change in the viral proteins but also a change in the conformation of the viral RNA. We ... Analysis of viral proteins. Proteins were characterized by either radioimmunoprecipitation or immunoblotting, using rabbit ... Efficient HIV-1 replication can occur in the absence of the viral matrix protein. EMBO J. 17:2699-2708. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC321369/?lang=en-ca
Coxsackie B4 virus - Wikipedia
... and 3A are core viral proteins. The genome also codes for 4 capsid proteins, VP4, VP1, VP2, and VP3 that form an icosahedral ... Once viral genome and viral proteins reach high enough concentrations within the host cell, structural proteins must assemble. ... UTR is the viral protein VPg which aids in viral entry and replication. 2A and 3C are viral proteinases which aid in the ... As soon as viral proteins have been translated and cleaved, negative sense transcripts of the viral genome are made to serve as ...https://en.wikipedia.org/wiki/Coxsackie_B4_virus
Investigation of the roles of viral proteinases in the vaccinia virus life cycle
These proteins are involved in the maturation of viral core proteins, p4a, p4b, and p25K, to form infectious virions. DNA ... state had significantly lower viral titers throughout the last 6 hours of the cycle. Viral core protein processing in the "on" ... Protein processing was difficult to effectively visualize, with the best processing occurring at a MOI of 0.2, using Fugene as ... The multiplicity of infection (MOI) was optimized, and a MOI of 0.5 was best, with a 99.25% reduction in viral plaque formation ...https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/x059c920x
Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis | Springer for Research...
Background Proteins associated with the late endosome (LE) appear to play a central role in the envelopment of a number of ... 6, right panel). This result suggests that these fractions contain envelope precursors and viral core proteins, but not intact ... To investigate this possibility, the isolated membrane fraction was probed with antibodies specific for the viral core proteins ... B) The viral proteins in each fraction were detected by immunoblot analysis using antisera against L4 and B5 proteins. IMV, ...https://rd.springer.com/article/10.1186/1743-422X-6-44
... the core protein binds to itself and related proteins to form the viral capsid, the outer lipid-encapsulated protein shell that ... Core proteins orchestrate the assembly and release of the infectious virus, as well as the disassembly of viral particles upon ... By targeting the interactions of the core protein with itself and with other proteins, Strosberg and his colleagues have sought ... Protein-protein interactions, which involve such key physiological actions as signal transduction and protein assembly, are ...https://www.scripps.edu/news/press/2009/121609.html