*  Lobeline Attenuates Methamphetamine-Induced Changes in Vesicular Monoamine Transporter 2 Immunoreactivity and Monoamine...
METH also affects the vesicular monoamine transporter 2 (VMAT-2), the protein that regulates the sequestration of monoamines ... Sandoval V, Riddle EL, Hanson GR, and Fleckenstein AE (2003) Methylphenidate alters vesicular monoamine transport and prevents ... The lobeline-mediated attenuation of the METH-induced decreases in vesicular VMAT-2 protein in the vesicular fraction at 1 and ... Lobeline Attenuates Methamphetamine-Induced Changes in Vesicular Monoamine Transporter 2 Immunoreactivity and Monoamine ...
  http://jpet.aspetjournals.org/content/312/1/160.long
*  Quantitative Analysis of Inward and Outward Transport Rates in Cells Stably Expressing the Cloned Human Serotonin Transporter:...
... plasmalemmal dopamine transporter versus vesicular monoamine transporter. Mol Pharmacol 47:368-373. ... 1998) Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices. J Pharmacol Exp Ther 284: ... It is well known that the K m value for substrate transport by monoamine transporters (Graefe and Bönisch, 1989) increases at ... Thus, reverse transport rates did not seem to be strictly coupled to ratios of inward transport, irrespective whether the cells ...
  http://molpharm.aspetjournals.org/content/59/5/1129
*  Vesicular monoamine transporter - Wikipedia
The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membrane of synaptic vesicles of ... Accessed 20 April 2013] Vesicular Monoamine Transport Proteins at the US National Library of Medicine Medical Subject Headings ... VMAT uses the same transport mechanism for all types of monoamines. VMATs transport monoamines from the cytosol into high- ... 2006). "Regulation of vesicular monoamine and glutamate transporters by vesicle-associated trimeric G-proteins: new jobs for ...
  https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter
*  Paraganglioma - Paragangliomas Summary Report | CureHunter
Vesicular Monoamine Transport Proteins (Vesicular Monoamine Transporter)IBA 06/01/2010 - "6-18F-fluoro-L-dihydroxyphenylalanine ... 08/01/2006 - "The aims of this study were to investigate the quantitative expression of vesicular monoamine transporters (VMAT ... 04/01/2011 - "Expression of somatostatin receptors, dopamine D₂ receptors, noradrenaline transporters, and vesicular monoamine ... or vesicular monoamine transporter 2 to predict paragangliomas, showing a prediction error of 0%. ". ...
  http://www.curehunter.com/public/keywordSummaryD010235-Paraganglioma-Paragangliomas.do
*  3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Studies in animals<...
... toxic effects on brain 5-HT neurons in animals and present new data indicating that levels of the type 2 vesicular monoamine ... toxic effects on brain 5-HT neurons in animals and present new data indicating that levels of the type 2 vesicular monoamine ... toxic effects on brain 5-HT neurons in animals and present new data indicating that levels of the type 2 vesicular monoamine ... toxic effects on brain 5-HT neurons in animals and present new data indicating that levels of the type 2 vesicular monoamine ...
  https://jhu.pure.elsevier.com/en/publications/34-methylenedioxymethamphetamine-ecstasy-induced-serotonin-neurot-7
*  Effects of dopaminergic drug treatments on in vivo radioligand binding to brain vesicular monoamine transporters. | DIAL.pr -...
Vesicular Biogenic Amine Transport Proteins ; Vesicular Monoamine Transport Proteins ; Biological Transport ; Brain ; COS Cells ... Animals ; Membrane Transport Proteins ; Mice ; Mice, Inbred Strains ; Neuropeptides ; Radioligand Assay ; Rats ; Rats, Sprague- ... Effects of dopaminergic drug treatments on in vivo radioligand binding to brain vesicular monoamine transporters. Primary tabs ... Home» Effects of dopaminergic drug treatments on in vivo radioligand binding to brain vesicular monoamine transporters. ...
  https://dial.uclouvain.be/pr/boreal/object/boreal:123339
*  Ephedrine Neurotoxicity
Intracellular DA depletion using the DA , synthesis inhibitor alpha-methyl-p-tyrosine or the vesicular monoamine , transport ... protein damage, and cell death. As in earlier studies, AMPH rapidly , redistributed vesicular DA to the cytoplasm, where it ... Despite these AMPH-induced changes, neither protein oxidation nor cell death , was observed until 1 and 4 days, respectively. ... recombinant glutathione-S-transferase fusion protein and delineated the , catalytic domain of the enzyme as the region spanning ...
  http://www.bio.net/bionet/mm/neur-sci/2003-May/054567.html
*  San Diego Source > Health > Neurocrine Biosciences granted two...
Nasdaq: NBIX) has announced that two more patents have been granted related to the company's proprietary Vesicular Monoamine ... a protein concentrated in the human brain that is primarily responsible for re-packaging and transporting monoamines, like ... Nasdaq: NBIX) has announced that two more patents have been granted related to the company's proprietary Vesicular Monoamine ...
  http://www.sddt.com/Health/article.cfm?Sourcecode=20130124tqb&_t=Neurocrine+Biosciences+granted+two+patents
*  Reuptake inhibitor - Wikipedia
... is an irreversible inhibitor of the vesicular monoamine transporter 2 (VMAT2), and is a prototypical example of a vesicular ... With vesicular transport blocked, neurotransmitter stores quickly become depleted. Reserpine (Serpasil) ... which exerts its effects by causing conformational changes in the transporter protein and thereby modulating the affinity of ... triethylcholine Vesicular acetylcholine transporter (VAChT) inhibitor - vesamicol Vesicular monoamine transporter (VMAT) ...
  https://en.wikipedia.org/wiki/Reuptake_inhibitor
*  Drug Transport in Living Systems - CHEMICAL BIOLOGY
... - reflects the multidimensional character of chemical biology, focusing in ... The vesicular monoamine transporters (VMATs) from the SLC18 family provide another example of polyspecific proteins with a very ... Membrane transport proteins recognize these drug molecules and in an energy-dependent manner transport them across the plasma ... Transport proteins. With MDTs the only detailed structural evidence is provided by AcrB. The recent structure of AcrB in the ...
  http://schoolbag.info/chemistry/chemical_biology/34.html
*  Enhancing Vesicular Packaging May Offer New Therapeutic Target for Parkinson's
Vesicular monoamine transporter 2 (VMAT2) is a protein that packages dopamine and other monoamine neurotransmitters into ... The VMAT2-overexpressing mice exhibited a two-fold increase in vesicular transport, which increased dopamine release 84 percent ... Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in ... Enhancing Vesicular Packaging May Offer New Therapeutic Target for Parkinson's Enhancing Vesicular Packaging May Offer New ...
  https://www.niehs.nih.gov/research/supported/sep/2014/enhancing_vesicular_packaging/
*  History of catecholamine research - Wikipedia
... and the vesicular monoamine transporter (VMAT) with two isoforms. Transporters and intracellular enzymes such as monoamine ... With the advent of molecular genetics, the three transport mechanisms have been traced to the proteins and their genes since ... I. Demonstration of monoamines in the cell bodies of brain stem neurons". Acta Physiologica Scandinavica. 62, suppl. 247: 1-55 ... It was later named monoamine oxidase. This seemed to clarify the fate of the catecholamines in the body, but in 1956 Blaschko ...
  https://en.wikipedia.org/wiki/History_of_catecholamine_research
*  Vesicular monoamine transporter 2 - Wikipedia
... is a protein that in humans is encoded by the SLC18A2 gene. VMAT2 is an integral membrane protein that transports monoamines- ... Little KY, Krolewski DM, Zhang L, Cassin BJ (January 2003). "Loss of striatal vesicular monoamine transporter protein (VMAT2) ... by simultaneously reversing the direction of transport through the primary plasma membrane transport proteins for monoamines (i ... Play media The vesicular monoamine transporter 2 (VMAT2) also known as solute carrier family 18 member 2 (SLC18A2) ...
  https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter_2
*  SLC18A3 Gene - GeneCards | VACHT Protein | VACHT Antibody
Protein Coding), Solute Carrier Family 18 Member A3, including: function, proteins, disorders, pathways, orthologs, and ... This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine ... of ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is found in the ... Protein details for SLC18A3 Gene (UniProtKB/Swiss-Prot). Protein Symbol:. Q16572-VACHT_HUMAN. Recommended name:. Vesicular ...
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC18A3
*  Immunomodulatory Effects Mediated by Dopamine
K. M. Ashe, W.-L. Chiu, A. M. Khalifa et al., "Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in ... S. M. Parsons, "Transport mechanisms in acetylcholine and monoamine storage," The FASEB Journal, vol. 14, no. 15, pp. 2423-2434 ... G. W. Miller, J. D. Erickson, J. T. Perez et al., "Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein ... 3.4.1. DRs Are G Protein-Coupled Receptors (GPCR). DRs belong to a superfamily of membrane proteins, called the G protein- ...
  https://www.hindawi.com/journals/jir/2016/3160486/
*  Catecholamines up - Wikipedia
... and Vesicular Monoamine Transporter (VMAT) in Drosophila melanogaster. Catsup plays a significant role in zinc ion ... transmembrane transport, and the mutations in Catsup gene can lead to abnormal accumulation of membrane proteins, such as Notch ... and Vesicular Monoamine Transporter (VMAT) enzyme activity. Various molecular polymorphisms of Catsup are associated with ... Catsup encoded protein is composed of seven predicted transmembrane domains and Catsup co-localizes with enzymes TH and VMAT to ...
  https://en.wikipedia.org/wiki/Catecholamines_up
*  Membrane transport protein - wikidoc
Membrane transport protein: neurotransmitter transporters. Vesicular. Vesicular monoamine (VMAT1, VMAT2) - Vesicular ... Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF- ... Active transport. Transport proteins are also used in active transport, which by definition does require an energy input. ... Transport proteins are integral membrane proteins; that is they exist within and span the membrane across which they transport ...
  http://es.wikidoc.org/index.php/Membrane_transport_protein
*  Gonzalo Torres
Proteins interacting with monoamine transporters: current state and future challenges.. Sager JJ, Torres GE.. Biochemistry. ... The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2. .. Requena DF, Parra LA, Baust TB, Quiroz M ... A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. .. Cartier EA, ... Monoamine Transporters: the role of oligomerization in transporter function, how transporter proteins are targeted to specific ...
  http://www.neurobio.pitt.edu/faculty/torres.htm
*  Characterization of Bacterial Drug Antiporters Homologous to Mammalian Neurotransmitter Transporters | Journal of Bacteriology
The vesicular monoamine transporter (VMAT) catalyzes the accumulation of neurotransmitters in organelles in exchange for two ... The result supports the contention that transport catalyzed by the three proteins is driven by proton electrochemical gradient. ... Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high ... The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters. FEBS Lett. 377:201 ...
  https://jb.asm.org/content/187/21/7518?ijkey=c39e9aac1ab9efcfd892be3c950485b8042eba96&keytype2=tf_ipsecsha
*  Vesicular monoamine transporter 1 - Wikipedia
SLC18A1 is an isoform of the vesicular monoamine transporter. The idea that there must be specific transport proteins ... This transport is facilitated via proton gradient generated by the protein proton ATPase. The inward transport of the monoamine ... Vesicular monoamine transporter 1 (VMAT1) also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 ... The active transport of monoamines from the cytosol into storage vesicles operates against a large (>105) concentration ...
  https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter_1
*  God gene - Wikipedia
In the brain, VMAT2 proteins are located on synaptic vesicles. VMAT2 transports monoamine neurotransmitters from the cytosol of ... VMAT2 codes for a vesicular monoamine transporter that plays a key role in regulating the levels of the brain chemicals ... called vesicular monoamine transporter 2 (VMAT2), predisposes humans towards spiritual or mystic experiences. The idea has been ... These monoamine transmitters are in turn postulated to play an important role in regulating the brain activities associated ...
  https://en.wikipedia.org/wiki/God_gene
*  Monoamine neurotransmitter - Wikipedia
3-Iodothyronamine Tryptamine Specific transporter proteins called monoamine transporters that transport monoamines in or out of ... In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine ... Monoamine receptor Monoamine oxidase Monoamine transporter Monoamine Hypothesis Biogenic amine Trace amine Monoamine nuclei ... "A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system". PLoS ...
  https://en.wikipedia.org/wiki/Monoamine_neurotransmitter
*  Rauwolfia serpentina root - DrugBank
Monoamine transmembrane transporter activity. Specific Function. Involved in the ATP-dependent vesicular transport of biogenic ... Protein binding. Not Available. Metabolism. Not Available. Route of elimination. Not Available. Half life. Not Available. ... Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.... Gene Name. ...
  https://www.drugbank.ca/drugs/DB09363
*  Monoamine releasing agent - Wikipedia
Once inside the presynaptic neuron, they may inhibit the reuptake of monoamine neurotransmitters through vesicular monoamine ... these transporters transport monoamines in reverse (i.e., they move monoamines from the neuronal cytoplasm into the synaptic ... which triggers a phosphorylation cascade via protein kinases that results in the phosphorylation of monoamine transporters ... A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the release of a monoamine ...
  https://en.wikipedia.org/wiki/Monoamine_releasing_agent
*  Crizotinib | Evolution of NADPH Oxidase Inhibitors
2003). In particular the acute phase reactant C-reactive protein (CRP) shows promise as a clinically useful marker of ... transport, rate of metabolism, and unfamiliar transcripts (Fig. S1). Testing using the cDNA libraries ready from bacteria ... Vesicular Monoamine Transporters Archives. *December 2017. *November 2017. *October 2017. *September 2017 ... These genes represent different mobile procedures including a chaperone proteins assisting in several cellular procedures (and ...
  http://biobeds.info/tag/crizotinib/