*  Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation. - Full Text View - ClinicalTrials.gov
This is a pilot study to test the effect of double dose augmentation therapy with Zemaira (CSL Behring) on lung inflammation, compared with standard doses of 60 mg/kg/week.. Our hypothesis is that some patients with AATD receiving augmentation therapy at the standard dose of 60 mg/kg/week continue to have a significant lung inflammation that may lead to detrimental clinical consequences. This inflammation can be further reduced with higher AAT dosing.. The study will enroll 20 subjects with AATD and COPD already receiving augmentation therapy with any brand at standard doses for at least a month. For inclusion and exclusion criteria see below.. Protocol:. The study will take place over approximately 12 weeks: a month receiving Zemaira at standard dose (60 mg/kg/week), a month at double dose (120 mg/kg/week) and a month at standard dose (60 mg/kg/week). The infusions at standard doses will be done at home and infusions with higher doses will be provided at the study site.. the study involves ...
  https://clinicaltrials.gov/ct2/show/NCT01669421?recr=Open&cond=%22alpha+1-Antitrypsin+Deficiency%22&rank=9
*  KCNJ13 Gene Augmentation Therapy to Treat Blindness due to Kir7.1 Defects | IOVS | ARVO Journals
Purpose : Mutations in the KCNJ13 gene, encoding the inwardly rectifying potassium Kir7.1 ion-channel in the RPE, cause autosomal dominant snowflake vitreoretinal degeneration (SVD) and autosomal recessive Leber's congenital amaurosis (LCA16). Molecular and biophysical analysis of the mutant protein revealed a non-functional protein product. With a goal of restoring retinal function via gene augmentation therapy, we tested the efficacy of Kir7.1 channel functional rescue using an in vitro model of CHO cells expressing disease - associated mutations. Methods : We cloned human Kir7.1-WT (wild-type) and W53X (mutant) into Flip-In™ expression vector (ThermoFisher Scientific) and transfected them into Chinese Hamster Ovary (CHO) cells to express the protein products. Expression of Kir7.1 was verified through PCR and Restriction fragment length polymorphism (RFLP) analysis. Whole-cell configuration of patch-clamp technology was used to measure Kir7.1 current. Protein expression was confirmed by ...
  http://iovs.arvojournals.org/article.aspx?articleid=2641233
*  Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis - The...
Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis Journal Articles Refereed ...
  https://www.findanexpert.unimelb.edu.au/display/publicationS985298
*  DMOZ - Health: Conditions and Diseases: Immune Disorders: Auto-Immune: Microscopic Polyangiitis
Microscopic polyangiitis (MPA), previously called hypersensitivity angiitis, is a systemic necrotizing vasculitis that involves many organ systems including the skin, joints, kidneys, and lungs.
  http://dmoztools.net/Health/Conditions_and_Diseases/Immune_Disorders/Auto-Immune/Microscopic_Polyangiitis/
*  Antineutrophil cytoplasmic antibody definition | Drugs.com
Definition of antineutrophil cytoplasmic antibody. Provided by Stedman's medical dictionary and Drugs.com. Includes medical terms and definitions.
  https://www.drugs.com/dict/antineutrophil-cytoplasmic-antibody.html
*  Catalog :: State Publications
S C H O O L O F I N F O R M A T I O N A N D L I B R A RY S C I E N C E VtàtÄÉz ECCJ@ECCK THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Published by the University of North Carolina at Chapel Hill Send all undeliverable copies and changes of address to: The School of Information and Library Science The University of North Carolina at Chapel Hill CB# 3360, 100 Manning Hall Chapel Hill, NC 27599-3360 This document was published by the School of Information and Library Science. SILS The School of Information and Library Science The University of North Carolina at Chapel Hill CB# 3360, 100 Manning Hall Chapel Hill, NC 27599-3360 919/962-8366; fax 919/962-8071 e-mail: info@ils.unc.edu http://sils.unc.edu THE GRADUATE SCHOOL CB# 4010, 200 Bynum Hall The University of North Carolina at Chapel Hill 919/966-2611; e-mail: gradinfo@unc.edu http://gradschool.unc.edu STUDENT LOANS AND FEDERAL ASSISTANCE Office of Scholarships and Student Aid The University of North Carolina at Chapel Hill CB# 2300, 300 ...
  http://digital.ncdcr.gov/cdm/compoundobject/collection/p249901coll22/id/695201/rec/39
*  Catalog :: State Publications
S C H O O L O F I N F O R M A T I O N A N D L I B R A RY S C I E N C E VtàtÄÉz ECCJ@ECCK THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Published by the University of North Carolina at Chapel Hill Send all undeliverable copies and changes of address to: The School of Information and Library Science The University of North Carolina at Chapel Hill CB# 3360, 100 Manning Hall Chapel Hill, NC 27599-3360 This document was published by the School of Information and Library Science. SILS The School of Information and Library Science The University of North Carolina at Chapel Hill CB# 3360, 100 Manning Hall Chapel Hill, NC 27599-3360 919/962-8366; fax 919/962-8071 e-mail: info@ils.unc.edu http://sils.unc.edu THE GRADUATE SCHOOL CB# 4010, 200 Bynum Hall The University of North Carolina at Chapel Hill 919/966-2611; e-mail: gradinfo@unc.edu http://gradschool.unc.edu STUDENT LOANS AND FEDERAL ASSISTANCE Office of Scholarships and Student Aid The University of North Carolina at Chapel Hill CB# 2300, 300 ...
  http://digital.ncdcr.gov/cdm/compoundobject/collection/p249901coll22/id/695201/rec/5
*  Chapel Hill Rehabilitation & Healthcare Center Nursing Home in Chapel Hill, NC
Chapel Hill Rehabilitation & Healthcare Center is a Nursing Home and Rehabilitation Center in Chapel Hill, NC. View patient reviews, address, phone number and driving directions here now.
  http://www.wellness.com/dir/2501106/nursing-home/nc/chapel-hill/chapel-hill-rehabilitation--healthcare-center
*  T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases
A broad array of evidence indicates that T lymphocytes make significant contributions to vascular inflammation in the setting of atherosclerotic disease, hypertension, autoimmune vasculitis, and other disorders. Experimental data show that costimulatory and coinhibitory pathways involving molecules of the B7-CD28 and TNF-TNFR families regulate T cell responses that promote vascular disease. Antigen presenting cells (APCs) display both peptide-major histocompatibility complex antigen and costimulators or coinhibitors to T cells. Two major types of APCs, dendritic cells (DCs) and macrophages, are present in significant numbers in the walls of arteries affected by atherosclerosis and arteritis, and some DCs are present in normal arteries. Costimulatory and coinhibitory molecules expressed by these vascular APCs can contribute to the activation or inhibition of effector T cells within the arterial wall. Vascular DCs may also be involved in transport of antigens to secondary lymphoid organs, ...
  https://dash.harvard.edu/handle/1/8615965
*  Tobacco Road Sports Cafe Chapel Hill, NC 27517 - YP.com
Get reviews, hours, directions, coupons and more for Tobacco Road Sports Cafe at 1118 Environ Way, Chapel Hill, NC. Search for other American Restaurants in Chapel Hill on YP.com.
  https://www.yellowpages.com/chapel-hill-nc/mip/tobacco-road-sports-cafe-474459816
*  Pigmented purpuric dermatoses (capillaritis)
The pigmented purpuric dermatoses (PPDs), also known as capillaritis, purpura simplex, and inflammatory purpura without vasculitis, are a group of chronic, benign, cutaneous eruptions characterized by the presence of petechiae, purpura, and increased
  https://www.uptodate.com/contents/pigmented-purpuric-dermatoses-capillaritis
*  Renal Fellow Network: Interesting Case of Adult Henoch-Schonlein Purpura
All opinions expressed on the website are those of the respective authors and not of their employer. Information provided here is for medical education only. It is not intended as and does not substitute for medical advice. If you are a patient, please see your doctor for evaluation. The appearance of external hyperlinks to other websites does not constitute endorsement. We do not verify, endorse or take responsibility for the accuracy, currency, completeness or quality of the content contained in these sites. There is no real life patient data on this website. The Renal Fellow Network does not profit from any of the material on this website. No advertisements are accepted. The Renal Fellow Network is not funded by any agency or company. Any information collected by our website, such as email addresses, will never be passed on to any third party, unless required by law. The Renal Fellow Network is moderated occasionally and posteriorly. Moderators are volunteers. Internet users posting comments ...
  http://renalfellow.blogspot.com/2009/02/interesting-case-of-adult-henoch.html
*  Cryoglobulinaemia dictionary definition | cryoglobulinaemia defined
cryoglobulinaemia definition: Noun (countable and uncountable, plural cryoglobulinaemias) 1. Alternative spelling of cryoglobulinemia....
  http://www.yourdictionary.com/cryoglobulinaemia
*  Psychosocial issues affect HIV/AIDS treatment outcomes: UNC ... ( CHAPEL HILL Psychosocial influence...)
Health, ...CHAPEL HILL Psychosocial influences such as stress depression and tr...Now a comprehensive update on those influences in the current issue o... A huge amount of research has been done in our field around these psy... We hope this special issue will serve as a catalyst for healthcare pr...,Psychosocial,issues,affect,HIV/AIDS,treatment,outcomes:,UNC,researcher,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
  http://www.bio-medicine.org/medicine-news-1/Psychosocial-issues-affect-HIV-AIDS-treatment-outcomes-3A-UNC-researcher-22177-1/
*  Scarring a necessary evil to prevent further damage after he... ( CHAPEL HILL N.C. After a heart atta...)
...CHAPEL HILL N.C. After a heart attack the portions of the heart dam...In a study appearing online November 15 2011 in the EMBO Journal... We now know that scarring is a good thing because it prevents a prec...Regeneration happens naturally in lower organisms like zebrafish the ...,Scarring,a,necessary,evil,to,prevent,further,damage,after,heart,attack,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
  http://www.bio-medicine.org/biology-news-1/Scarring-a-necessary-evil-to-prevent-further-damage-after-heart-attack-22427-1/
*  UNC researchers find clue to stopping breast-cancer ... ( CHAPEL HILL If scientists knew exac...)
Health, ...CHAPEL HILL If scientists knew exactly what a breast cancer cell need...Carol Otey Ph.D. and UNC colleagues reduced the ability of breast can...They also found higher levels of palladin in four invasive breast canc... This study shows that palladin may play an important role in the meta...,UNC,researchers,find,clue,to,stopping,breast-cancer,metastasis,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
  http://www.bio-medicine.org/medicine-news-1/UNC-researchers-find-clue-to-stopping-breast-cancer-metastasis-29961-1/
*  Find Best Dentists in Chapel Hill, NC - Reviews & Appointments
Dentists in Chapel Hill, NC, See Reviews and Book Online Instantly. It's free! All appointment times are guaranteed by our dentists and doctors.
  https://www.zocdoc.com/dentists/chapel-hill-250384pm
*  Programming Instructor $30,000 Jobs, Employment in Chapel Hill, NC | Indeed.com
12 Programming Instructor $30,000 jobs available in Chapel Hill, NC on Indeed.com. Clinical Nurse Educator, Computer Instructor, Marketing Manager and more!
  http://www.indeed.com/q-Programming-Instructor-$30,000-l-Chapel-Hill,-NC-jobs.html
*  Publications Jan 2017 - Aug 2017 | Intelligent Systems Program | University of Pittsburgh
The Effect Of PiZ Genotype And Augmentation Therapy On Bronchoalveolar Lavage (BAL) And Peripheral Blood Mononuclear Cell (PBMC) Transcriptomes In Alpha-1 Antitrypsin Deficiency [Link] ...
  http://www.isp.pitt.edu/resources/publication
*  Dr. Eugenie Du, MD - Chapel Hill, NC - Ear, Nose, and Throat | Healthgrades.com
Visit Healthgrades for information on Dr. Eugenie Du, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
  https://www.healthgrades.com/physician/dr-eugenie-du-gcyss
*  Dr. Jason Boothe, MD - Chapel Hill, NC - Family Medicine | Healthgrades.com
Visit Healthgrades for information on Dr. Jason Boothe, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
  https://www.healthgrades.com/physician/dr-jason-boothe-y9pvryz
*  Dr. Reid Draeger, MD - Chapel Hill, NC - Orthopedic Surgery | Healthgrades.com
Visit Healthgrades for information on Dr. Reid Draeger, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
  https://www.healthgrades.com/physician/dr-reid-draeger-gh5s7
*  Overview of the management of vasculitis in adults
The vasculitides are defined by the presence of leukocytes in the vessel wall with reactive damage to mural structures. In general, affected vessels vary in size, type, and location in association with the specific vasculitic disorder. These conditio
  https://www.uptodate.com/contents/overview-of-the-management-of-vasculitis-in-adults
*  DigitalNC
K-JK) START OF TAPE 1, SIDE A LUCY LEWIS FEBRUARY 19, 2001 LILI LAI: Today is February 19; I'm interviewing Ms. Lucy Lewis. Were you born in Chapel Hill, here? LUCY LEWIS: No, I was ...
  http://dc.lib.unc.edu/cdm/search/searchterm/Colors/mode/exact
*  Indications / Contraindication
Contact Us UNC Division of Transplant 4024 Burnett Womack Building CB #7211 Chapel Hill NC 27599-7211 Phone 919-966-8008 Fax 919-966-6308 Español: 919-966-3464 ...
  http://www.med.unc.edu/transplant/patientinfo/Ltrans/indications-contraindication